Human Genetics
Specific BRCA1 gene variations amongst young Moroccan breast cancer patients
Authors: A. Tazzite, S. Nadiffi, D. Kottwitz, M. El Amrani, H. Jouhadi,A. Benider, A. Moumen4 and H. Sefrioui
Germline mutations in the BRCA1 gene are known predictive markers for the development of hereditary breast cancer. Nevertheless, no comprehensive study has been performed targeting the presence and relevance of BRCA1 mutations in Moroccan breast cancer patients. We here present an analysis of BRCA1 gene regions (exon 2 and exo.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.31.5
- DOI:
- http://dx.doi.org/10.4238/2014.January.31.5
G501C polymorphism of the oxidized LDL receptor gene is associated with albuminuria in Chinese essential hypertension patients
Authors: X.W. Hou, Z.H. Hu, Y. Cui, W. Gao, S.P. Sun and N.F. Wang
Albuminuria is an independent predictor of renal and cardiovascular complications in hypertensive subjects. We previously showed that lectin-like oxidized low-density lipoprotein receptor 1 (OLR-1) polymorphisms at G501C are associated with susceptibility to essential hypertension and serum C-reactive protein levels. We have n.. Read More»
- Genet. Mol. Res. 10(4):
Tetrandrine induces microRNA differential expression in human hypertrophic scar fibroblasts in vitro
Authors: Tetrandrine induces microRNA differential expression in human hypertrophic scar fibroblasts in vitro
MicroRNAs (miRNAs) have recently been shown to play a role in normal wound healing process. miRNAs may be linked to pathologic wound healing and closely related to the formation of hypertrophic scars. This study aimed to explore the effects of tetrandrine on the miRNA expression profile in human hypertrophic scar fibroblasts (HSFs) in vitro. HSFs were ran.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017288
- DOI:
- 10.4238/gmr.15017288
Evaluation of concentrations of botulinum toxin A for the treatment of hemifacial spasm: a randomized double-blind crossover trial
Authors: Y.J. Li, Y. Huang, Q. Ding, Z.H. Gu and X.L. Pan
The aim of our study was to evaluate the efficacy and safety of two concentrations of botulinum toxin A (BTX-A) for the treatment of hemifacial spasm. We randomly divided 20 patients with hemifacial spasm into high- and low-concentration groups; they were administered 50 and 25 U/mL BTX-A injection, respectively. Further, we compared the curative effects .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.17
- DOI:
- 10.4238/2015.February.6.17
Relationship between serum adiponectin and osteoprotegerin levels and coronary heart disease severity
Authors: H.L. Zhang and X. Jin
This study aimed to explore serum adiponectin and osteoprotegerin levels in patients with coronary heart disease (CHD) and their correlation with inflammatory and ischemia factors. From September 2010 to Augest 2010, 347 CHD patients were enrolled for a retrospective analysis. Serum lipoprotein phospholipase A2 (Lp-PLA2), hypersensitive C-reactive protein.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.15
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.15
Effect of CYP2C9*3 mutant variants on meloxicam pharmacokinetics in a healthy Chinese population
Authors: M. Zhang, Y. Yang, G. Zhao, X. Di, L. Xu, N. Jiang, J. Xu and X. Xu
The aim of this study was to investigate the effect of the CYP2C9*3 (CYP2C9 1075 A>C) polymorphism on meloxicam pharmacokinetics in a Chinese population. Twenty-four healthy volunteers were enrolled in this study. The pyrosequencing technique was used to identify polymorphisms of CYP2C9. The concentration of meloxicam in pl.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.13.1
- DOI:
- 10.4238/2014.February.13.1
Association of the FABP2 Ala54Thr polymorphism with type 2 diabetes, obesity, and metabolic syndrome: a population-based case-control study and a systematic meta-analysis
Authors: Y. Liu, G. Wu, L. Han, K. Zhao, Y. Qu, A. Xu and Q. Huang
Previous studies have reported associations between the functional FABP2 Ala54Thr (rs1799883) polymorphism and type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome in different populations with conflicting results. We investigated the association between the FABP2 Ala54Thr polymorphism and T2DM (235 cases, 431 controls), obesity (377 cases, 43.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.19
- DOI:
- 10.4238/2015.February.6.19
Docetaxel enhances apoptosis and G2/M cell cycle arrest by suppressing mitogen-activated protein kinase signaling in human renal clear cell carcinoma
Authors: T.D. Han, D.H. Shang and Y. Tian
Tremendous efforts have been made in renal cell carcinoma (RCC) patients’ research; however, clinical findings in patients have been disappointing. The aims of our study were to identify better or alternative therapeutic methods that can reverse chemotherapy resistance and to enhance sensitivity to docetaxel (DOX)-based chemotherapy drugs. We evalua.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017321
- DOI:
- 10.4238/gmr.15017321
Genetic differentiation of octopuses from different habitats near the Korean Peninsula and eastern China based on analysis of the mDNA cytochrome C oxidase 1 gene
Authors: J.-H. Kang J.-Y. Park T.-J. Choi
Distributed along the coastal waters of Korea and China, Octopus minor is found in various habitats, including the mud flats in the southern and western coasts of the Korean Peninsula and the rocky areas around Jeju Island; however, the genetic relationships among the different populations are unknown and have not been studied. We compared 630-nucleotide seq.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.21.2
- DOI:
- 10.4238/2012.November.21.2
Association between IL-1�± rs17561 and IL-1�² rs1143634 polymorphisms and periodontitis: a meta-analysis
Authors: W.T. Yin, Y.P. Pan and L. Lin
Genetic variations in human interleukin-1 (IL-1) genes are known to be involved in inflammatory disorders. The rs17561 and rs1143634 polymorphisms of IL-1α and IL-1β, respectively, have been increasingly recognized as important regulators in the development of periodontitis. However, the existence of a specific association remains controversial.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017325
- DOI:
- 10.4238/gmr.15017325