Human Genetics
Screening of key genes of unruptured intracranial aneurysms by using DNA microarray data analysis techniques
Authors: L. Chen, Y. Fan and J. Wan
This study aimed to identify differentially expressed genes (DEGs) of unruptured intracranial aneurysms (IAs) and provide beneficial information for early diagnosis and treatment of IAs. The gene expression profile GSE26969 from the Gene Expression Omnibus database was downloaded, which included six human IA samples: three int.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.31.2
- DOI:
- 10.4238/2014.January.31.2
De novo assembly and characterization of Gleditsia sinensis transcriptome and subsequent gene identification and SSR mining
Authors: S. Han, Z. Wu, X. Wang, K. Huang, Y. Jin, W. Yang and H. Shi
Gleditsia sinensis is a Chinese native deciduous tree with a high economic and medicinal value. However, there is limited knowledge on the molecular processes responsible for the medical properties of this species owing to lack of bioinformatic resources such as available whole-genome sequences. In the present study, RNA sequencing data were used to analy.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017740
- DOI:
- 10.4238/gmr.15017740
Genetic evidence for panmixia of Japanese eel (Anguilla japonica) populations in China
Authors: X.L. Gong, S.J. Ren, Z.K. Cui and L.J. Yue
The Japanese eel population has dramatically declined since the 1970s. In order to conserve this species, the background genetic structure affecting these populations should be well documented. Previous genetic studies of this species have produced seemingly conflicting results, ranging from no detectable heterogeneity to smal.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.31.3
- DOI:
- 10.4238/2014.January.31.3
MYH9 gene polymorphisms may be associated with cerebrovascular blood flow in patients with type 2 diabetes
Authors: C. Ling, C.Y. Cai, B.C. Chang, W.T. Shi, F.J. Wei, P. Yu, L.M. Chen and W.D. Li
Genetic factors play an important role in type 2 diabetes (T2D) complications. Alteration of cerebrovascular blood flow (CBF) is a direct result of cerebrovascular diseases. However, few studies have reported the role of genetics on CBF in patients with T2D. We investigated whether single-nucleotide polymorphisms (SNPs) in metabolic disease genes are asso.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.4
- DOI:
- 10.4238/2015.February.6.4
Genetic variation and balancing selection at MHC class II exon 2 in cultured stocks and wild populations of orange-spotted grouper (Epinephelus coioides)
Authors: Z.N. Meng S. Yang B. Fan L. Wang H.R. Lin
Major histocompatibility complex (MHC) molecules play vital roles in triggering adaptive immune responses and are considered the most variable molecules in vertebrates. Recently, many studies have focused on the polymorphism and evolution mode of MHC in both model and non-model organisms. Here, we analyzed the MHC class II exon 2-encoding Ã?² chain in compa.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.12.4
- DOI:
- 10.4238/2012.November.12.4
Developmental methylation pattern regulates porcine GPR120 expression
Authors: H.M. Wang*, J.D. Ma*, L. Jin, Y.H. Liu, T.D. Che, M.Z. Li and X.W. Li
DNA methylation is an important component of the epigenetic machinery and plays a critical role in transcriptional regulation. It mostly occurs in CpG abundant regions, known as CpG islands (CGIs). G protein-coupled receptor 120 (GPR120) functions as an omega-3 fatty acid receptor and is involved in multiple-biological processes, including lipogenesis. He.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15014240
- DOI:
- 10.4238/gmr.15014240
Association of PS1 1/2, ACE I/D, and LRP C/T polymorphisms with Alzheimer�s disease in the Chinese population: a meta-analysis of case-control studies
Authors: L. Yang, H.-H. Zhou, Y.-F. Ye, X.-W. Fan, Y.-J. Wang and Y. Meng
The objective of this study was to assess the associations of presenilin 1 (PS1) 1/2, angiotensin I-converting enzyme (ACE) insertion/deletion (I/D), and low-density lipoprotein receptor-related protein (LRP) C/T polymorphisms with the risk of Alzheimer’s disease (AD) in the Chinese population. PS1 1/2, ACE I/D, and LRP C/T, which are commonly inves.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.5
- DOI:
- 10.4238/2015.February.6.5
Overexpression of NaKR3 enhances salt tolerance in Arabidopsis
Authors: Q. Luo1,2, Z. Zhao1, D.K. Li1, Y. Zhang1, L.F. Xie1, M.F. Peng1, S. Yuan3 and Y. Yang1,2
Salinity is a major abiotic stress in agriculture. Here, we report that SODIUM POTASSIUM ROOT DEFECTIVE3 (NaKR3), which encodes a heavy metal-associated domain protein, is involved in salt tolerance in Arabidopsis. The results of quantitative reverse transcription-polymerase chain reaction analysis revealed that NaKR3 was induced by high salinity and osmo.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016378
- DOI:
- 10.4238/gmr.15016378
Quantitative real-time polymerase chain reaction as an efficient molecular tool for detecting minimal residual disease in Moroccan chronic myeloid leukemia patients
Authors: A. Moumen, H. Dehbi, D. Kottwitz, M. El Amrani,N. Bouchoutrouch, H. El Hadi, A. Quessar, S. Benchekroun,S. Nadifi and H. Sefrioui
Chronic myeloid leukemia (CML) is characterized by BCR-ABL translocation and an increased number and migration of immature myeloid cells into the peripheral blood. The detection limit of the BCR-ABL transcript, particularly after treatment, is controversial. In the present study, we used quantitative real-time reverse transcription-polymerase chain reacti.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.8
- DOI:
- 10.4238/2015.February.6.8
Molecular cloning, tissue expression pattern, and copy number variation of porcine SCUBE3
Authors: X. Liu*, L.G. Wang*, L.C. Zhang, H. Yan, K.B. Zhao, J. Liang, N. Li, L. Pu,T. Zhang and L.X. Wang
The signal peptide CUB EGF-like domain-containing protein 3 (SCUBE3) gene is a member of SCUBE gene family and plays important roles in bone cell biology and the determination of limb bone length. In this study, the full-length transcript of porcine SCUBE3 was cloned using reverse transcription-polymerase chain reaction and rapid amplification of cDNA end.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017010
- DOI:
- 10.4238/gmr.15017010