Cytogenomics
Meta-analysis of the relationship between the LOC387715/ARMS2 polymorphism and polypoidal choroidal vasculopathy
Authors: J.J. Jiang X. Wu P. Zhou W.Z. Yu L.Z. Huang X.X. Li
We investigated the association between the LOC387715/ARMS2 polymorphism (rs10490924 G>T) and susceptibility to polypoidal choroidal vasculopathy (PCV) through a meta-analysis of 1446 cases and 3255 controls from eight case-control studies. The genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism on PCV was assessed by calculating pooled odds ra.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.December.17.1
- DOI:
- 10.4238/2012.December.17.1
Homology cloning, sequence characterization, and expression analysis of cDNA encoding electron transfer flavoprotein beta polypeptide in mud crab (Scylla paramamosain)
Authors: X.L. Hao H.F. Yao Y.Z. Cheng R.X. Wang
Electron transfer flavoproteins (ETFs) are αβ-heterodimers found in eukaryotic mitochondria and bacteria. Herein we report a full-length complementary DNA of a mud crab (Scylla paramamosain) ETF β subunit (Scpa-ETFB) isolated with a homology cloning strategy. The complete complementary DNA of the Scpa-ETFB cont.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.12.11
- DOI:
- 10.4238/2012.November.12.11
Genetic variation of Kaempferia (Zingiberaceae) in Thailand based on chloroplast DNA (psbA-trnH and petA-psbJ) sequences
Authors: J. Techaprasan, S. Klinbunga, C. Ngamriabsakul and T. Jenjittikul
Genetic variation and species authentication of 71 Kaempferia accessions (representing 15 recognized, six new, and four unidentified species) found indigenously in Thailand were examined by determining chloroplast psbA-trnH and partial petA-psbJ spacer sequences. Ten closely related species (Boesenbergia rotunda, Gagnepainia g.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr873
- DOI:
- 10.4238/vol9-4gmr873
Simple sequence repeat-based assessment of genetic relationships among Prunus rootstocks
Authors: Z. Turkoglu, S. Bilgener, S. Ercisli, M. Bakir, A. Koc, M. Akbulut, R. Gercekcioglu, M. Gunes and A. Esitken
Ten SSR loci, previously developed for Prunus, were analyzed to examine genetic relationships among 23 rootstock candidates for sweet and sour cherries, of the species P. avium, P. cerasus, P. mahaleb, and P. angustifolia. Five genotypes of P. laurocerasus, not used as rootstock, were included in the molecular analysis. The nu.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr957
- DOI:
- 10.4238/vol9-4gmr957
Lack of association of genetic polymorphisms of angiotensin-converting enzyme gene I/D and glutathione-S-transferase enzyme T1 and M1 with retinopathy of prematures
Authors: M. Yildiz, M. Karkucak, T. Yakut, O. Gorukmez and A. Ozmen
One of the most frequently observed causes of blindness in infancy is the pathogenesis known as retinopathy of prematurity (ROP). Angiotensin-converting enzyme (ACE) is a vital enzyme in the renin-angiotensin-aldosterone system; it is involved in the development of cardiovascular system diseases linked to I/D polymorphism of t.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr887
- DOI:
- 10.4238/vol9-4gmr887
Involvement of CYP1A1, GST, 72TP53 polymorphisms in the pathogenesis of thyroid nodules
Authors: A.A.S. Reis, D.M. Silva, M.P. Curado and A.D. da Cruz
Specific genotypes appear to be related to the development of thyroid disease. We examined whether polymorphisms of the genes CYP1A1, GSTM1, GSTT1, and TP53 at codon 72 are associated with increased risk for thyroid nodules. Blood samples were obtained from 122 thyroid patients with nodules and from 134 healthy control individ.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr807
- DOI:
- 10.4238/vol9-4gmr807
Screening of crucial long non-coding RNAs in oral epithelial dysplasia by serial analysis of gene expression
Authors: X. Han, Y.B. Wei, G. Tian, Z. Tang, J.Y. Gao and X.G. Xu
Oral epithelial dysplasia (OED) is a premalignant lesion of the oral mucosa. Considering the poor 5-year survival rate of oral cancer, further investigation is needed in order to determine the pathogenesis of OED. In the present study, serial analysis of gene expression (SAGE) data from patients with OED were compared to norma.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.6
- DOI:
- 10.4238/2015.October.2.6
Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation
Authors: R. Wang, J. Zheng, D.-S. Zhang, Y.-H. Yang and Z.-F. Zhao
Osteosarcoma is one of the most common primary bone tumors in children and young adults. In this study, we investigated the role of musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK) in osteosarcoma cell proliferation in vitro and the possible pathways that contributed to MAFK-related osteosarcoma development. We first reported that MAFK was expres.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.7
- DOI:
- 10.4238/2015.July.3.7
RNA interference-mediated URG4 gene silencing diminishes cyclin D1 mRNA expression in HepG2 cells
Authors: N.L. Satiroglu-Tufan, Y. Dodurga, D. Gok, A. Cetinkaya and M.A. Feitelson
Up-regulated gene 4 (URG4), stimulated by HBxAg, is a novel gene located on chromosome 7 (7p13). The full-length URG4 clone is 3.607 kb and encodes a polypeptide of 922 amino acids, with a molecular weight of 104 kDa (GeneID: 55665). It promotes cell growth, growth factor-independent survival, and anchorage-independent growth .. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr872
- DOI:
- 10.4238/vol9-3gmr872
Worldwide diversity of the Y-chromosome tetra-local microsatellite DYS464
Authors: F.S.G. Kehdy and S.D.J. Pena
Of all DNA markers on the human Y-chromosome, the tetra-local Y-linked microsatellite DYS464 is the most polymorphic. We genotyped DYS464 in 677 male samples collected worldwide, maintained in the HGDP-CEPH Human Genome Diversity Cell Line Panel. Fourteen different alleles were found, with allele lengths varying from 9 to 23 r.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr968
- DOI:
- 10.4238/vol9-3gmr968