Cytogenomics
Regulation of WNK4 gene transcription in the kidneys
Authors: Z.J. Sun, Y. Li, Y.H. Li, J.S. Zhang, Q. Ding, J. Li-Ling, Y. Liang and Y.Y. Zhao
With-no-lysine (K) kinase-4 (WNK4) is a newly cloned kinase-encoding gene that plays a crucial role in the maintenance of electrolyte homeostasis. Mutations of WNK4 can cause pseudohypoaldosteronism type α, an autosomal dominant disease characterized by hyperkalemia, metabolic acidosis and hypertension. We explored the expression and regulatory mech.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.4.9
- DOI:
- 10.4238/2013.January.4.9
Maintaining and restoring cytoplasmic male sterility systems in pepper (Capsicum annuum L.)
Authors: Y. Ma, W. Huang, J.-J. Ji, Z.-H. Gong, C.-C. Yin, S.S. Ahmed and Z.-L. Zhao
We studied the efficiency of maintaining and restoring cytoplasmic male sterility (CMS) systems in pepper (Capsicum annuum L.). An Rf-linked molecular marker was employed to analyze the interaction between 6 CMS lines (A), 5 maintainers (B), and 6 restorers (C). Sterility was maintained in the matings of lines 201A x 200B, 203A x 200B, 206A x 200B, 200A x.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.4.8
- DOI:
- 10.4238/2013.January.4.8
Cytogenetic characteristics of patients with signs and symptoms of myelodysplastic syndromes in the State of Par�¡, Brazil
Authors: Giovanny RebouÃ?§as Pinto, David James Overal, Leopoldo Silva de Moraes, Ana VirgÃ?Ânia Van Den Berg, JosÃ?© Alexandre Rodrigues Lemos, MarÃ?Âlia de Arruda Cardoso Smith and Rommel RodrÃ?Âguez Burbano
The myelodysplastic syndromes (MDS) are clonal hematopoietic diseases characterized by medullary dysplasia, cytopenias, and frequent evolution to acute myeloid leukemia. In 1982, the French- American-British (FAB) group proposed a classification for the MDS, based on morphological characteristics of peripheral blood and of the.. Read More»
- Genet. Mol. Res. 4(1):
Genetic evaluation using multi-trait and random regression models in Simmental beef cattle
Authors: R.R. Mota, L.F.A. Marques, P.S. Lopes, L.P. da Silva, F.R.A. Neto, M.D.V. de Resende and R.A. Torres
The Brazilian Association of Simmental and Simbrasil Cattle Farmers provided 29,510 records from 10,659 Simmental beef cattle; these were used to estimate (co)variance components and genetic parameters for weights in the growth trajectory, based on multi-trait (MTM) and random regression models (RRM). The (co)variance components and genetic parameters wer.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.24.2
- DOI:
- 10.4238/2013.July.24.2
Genetic evaluation of Alpine goats using different milk control intervals
Authors: F.G. Silva, R.A. Torres, L.F. Brito, L.P. Silva, G.R.O. Menezes, L.C. Brito, R.F. Euclydes and M.T. Rodrigues
The objective of this study was to compare the results of genetic evaluations by using different milk control intervals to reduce the cost of milk yield controls without harming the quality of genetic evaluation of the animals. We analyzed test day milk yield data from the Goat Sector of Universidade Federal de Viçosa. After editing and checking fo.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.24.1
- DOI:
- 10.4238/2013.July.24.1
Adaptability and genotypic stability of Coffea arabica genotypes based on REML/BLUP analysis in Rio de Janeiro State, Brazil
Authors: W.P. Rodrigues, H.D. Vieira, D.H.S.G. Barbosa, G.R. Souza Filho and L.S. Candido
Biannuality in coffee culture causes temporal variability in plant productivity. Consequently, it is essential to evaluate genotypes during various crop years to ensure selection of productive and stable genotypes. We evaluated the effectiveness of simultaneous selection of coffee genotypes along harvests, based on productivity, stability, and adaptabilit.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.15.2
- DOI:
- 10.4238/2013.July.15.2
TLR4 gene expression in pig populations and its association with resistance to Escherichia coli F18
Authors: J. Wang, Z.Y. Pan, X.R. Zheng, Z.C. Wu, X.M. Su, G.Q. Zhu, X.G. Huang, S.L. Wu and W.B. Bao
TLR4 is the main recognition receptor of bacterial lipopolysaccharides, which play an important role in innate and adaptive immunity. We used real-time PCR to analyze the tissue expression profile and differential expression of TLR4 in 4 pig populations (Escherichia coli F18-resistant Sutai, E. coli F18-sensitive Sutai, Large White, Meishan), in order to .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.30.1
- DOI:
- 10.4238/2013.July.30.1
Genotoxic evaluation of the antimalarial drugs artemisinin and artesunate in human HepG2 cells and effects on CASP3 and SOD1 gene expressions
Authors: I. Aquino, M.S.F. Tsuboy, J.C. Marcarini, M.S. Mantovani, F.F. Perazzo and E.L. Maistro
The malaria treatment recommended by the World Health Organization involves medicines derived from artemisinin, an active compound extracted from the plant Artemisia annua, and some of its derivatives, such as artesunate. Considering the lack of data regarding the genotoxic effects of these compounds in human cells, the objective of this study was to eval.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.24.6
- DOI:
- 10.4238/2013.July.24.6
Analysis of differential gene expression during floral bud abortion in radish (Raphanus sativus L.)
Authors: J. Zhang, X.L. Sun, L.G. Zhang, M.X. Hui and M.K. Zhang
Radish floral bud abortion (FBA) is an adverse biological phenomenon that occurs during reproduction. Although FBA occurs frequently, its mechanism remains unknown. To elucidate the molecular mechanism underlying FBA, we detected gene expression differences between aborted and normal buds of radish using cDNA-amplified fragment length polymorphism (AFLP) .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.24.5
- DOI:
- 10.4238/2013.July.24.5
Association of novel single nucleotide polymorphisms of the CXCR1 gene with the milk performance traits of Chinese native cattle
Authors: L. Zhou, H.M. Wang, Z.H. Ju, Y. Zhang, J.M. Huang, C. Qi, M.H. Hou, L.G. An, J.F. Zhong and C.F. Wang
Mastitis is an economically devastating disease affecting the dairy industry. Dairy cows with mastitis give reduced milk yield and produce milk that is unfit for consumption. The chemokine receptor CXCR1 is an excellent prospective genetic marker for mastitis resistance in cattle because it regulates neutrophil migration, killing, and survival during infe.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.30.10
- DOI:
- 10.4238/2013.July.30.10