Cytogenomics
Complete mitochondrial genome of Cabot�s tragopan, Tragopan caboti (Galliformes: Phasianidae)
Authors: X.Z. Kan, X.F. Li, Z.P. Lei, M. Wang, L. Chen, H. Gao and Z.Y. Yang
Cabot’s tragopan, Tragopan caboti, is a globally threatened pheasant endemic to southeast China. The complete mitochondrial genome of Cabot’s tragopan was sequenced. The circular genome contains 16,727 bp, encoding a standard set of 13 protein-coding genes, two ribosomal RNA genes, and 22 transfer RNA genes, plus t.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr820
- DOI:
- 10.4238/vol9-2gmr820
A novel insertion mutation in the ADAR1 gene of a Chinese family with dyschromatosis symmetrica hereditaria
Authors: C.Y. Zhu, K.J. Zhu, Y. Zhou and Y.M. Fan
Dyschromatosis symmetrica hereditaria (DSH) is an autosomal dominant pigmentary genodermatosis, characterized by a mixture of hyperpigmented and hypopigmented macules that are mainly present on the dorsal portions of the extremities. The DSH locus was mapped to chromosome 1q11-q12 and, subsequently, pathogenic mutations in the double-stranded RNA-specific.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.12.1
- DOI:
- 10.4238/2013.August.12.1
Development and characterization of microsatellite primers in Pogostemon cablin (Lamiaceae)
Authors: S.S. Sandes, J.B. Pinheiro, M.I. Zucchi, M. Monteiro, M.F. Arrigoni-Blank and A.F. Blank
Microsatellite primers were developed and optimized for patchouli (Pogostemon cablin) to characterize the patchouli Active Germplasm Bank of Universidade Federal de Sergipe. Creation of a genomic library for patchouli enabled the design of 12 microsatellite primers. Six of these microsatellites were polymorphic, revealing two well-defined groups of indivi.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.8.4
- DOI:
- 10.4238/2013.August.8.4
Genetic variations in the active efflux pump genes acrA/B and tolC in different drug-induced strains of Escherichia coli CVCC 1547
Authors: J.H. Liu, Y.S. Pan, L. Yuan, H. Wu, G.Z. Hu and Y.X. Chen
This study aimed to investigate the properties of mutations of the active efflux pump genes acrA/B and tolC in Escherichia coli CVCC 1547 when induced by different drugs. The mutations were isolated in vitro by exposing E. coli CVCC 1547 to stepwise increases in the concentration of ceftriaxone (CRO), amikacin (AMK), or ciprofloxacin. The results showed t.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.8.3
- DOI:
- 10.4238/2013.August.8.3
Single-nucleotide polymorphism of the pri-miR-34b/c gene is not associated with susceptibility to congenital heart disease in the Han Chinese population
Authors: Y.-M. Liu, Y. Wang, W. Peng, Z. Wu, X.-H. Wang, M.-L. Wang, W. Wang, J. Sun, Z.-D. Zhang and X.-M. Mo
Recent evidence has shown that the microRNA polymorphism may play an important role in the susceptibility to congenital heart disease (CHD). A potentially functional SNP rs4938723 (T>C) in the promoter region of pri-miR-34b/c might affect transcription factor GATA binding and therefore pri-miR-34b/c expression. We genotyped the pri-miR-34b/c polymorphi.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.12.9
- DOI:
- 10.4238/2013.August.12.9
In situ analysis of apoptosis in Aspergillus nidulans with ethidium bromide and acridine orange
Authors: S.M. Leles, R. Factori and C.L.M.S.C. Rocha
Apoptosis and necrosis are among several types of cell death. We stained the nuclei of Aspergillus nidulans grown in micro-colonies with ethidium bromide and acridine orange to detect in situ apoptosis. Suspensions of conidia from 5-day-old colonies of the A. nidulans strains biA1methG1, G422, CLC100, and CLB3 were each put into two tubes. The suspension .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.12.5
- DOI:
- 10.4238/2013.August.12.5
IL-10 promoter SNPs and susceptibility to leprosy in ethnic groups from southwest China
Authors: X.H. Chen, J.H. Xiong, Y. Ning, Y. Wen, J. Liu, C. Mao, X.M. Weng and J.C. Gu
The purpose of this study was to determine whether interleukin-10 (IL-10) promoter polymorphisms are associated with leprosy or their subtypes in ethnic groups from southwest China. Genotyping using TaqMan® SNP Genotyping Master Mix and ABI 7500 real-time PCR system was performed for IL-10 T3575A, G2849A, C2763A, A1082G, C.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.12.3
- DOI:
- 10.4238/2013.August.12.3
Toll-like receptor (TLR)-2/4 expression in retinal ganglion cells in a high-glucose environment and its implications
Authors: M. Zhao, C.H. Li and Y.L. Liu
Diabetic retinopathy (DR), a major complication of diabetes mellitus, is the leading cause of adult blindness. The Toll-like receptor (TLR) family is believed to be involved in the pathogenesis and progression of DR. Here, we investigated the expression profiles of TLR-2 and TLR-4 in retinal ganglion cells (RGCs), in an attemp.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026998
- DOI:
- 10.4238/gmr.15026998
DNA repair mutant pso2 of Saccharomyces cerevisiae is sensitive to intracellular acetaldehyde accumulated by disulfiram-mediated inhibition of acetaldehyde dehydrogenase
Authors: M. Brendel, G. Marisco, I. Ganda, R. Wolter and C. Pungartnik
Blocking aldehyde dehydrogenase with the drug disulfiram leads to an accumulation of intracellular acetaldehyde, which negatively affects the viability of the yeast Saccharomyces cerevisiae. Mutants of the yeast gene PSO2, which encodes a protein specific for repair of DNA interstrand cross-links, showed higher sensitivity to .. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr695
- DOI:
- 10.4238/vol9-1gmr695
Identification and assessment of differentially expressed genes involved in growth regulation in Apostichopus japonicus
Authors: L. Zhu,C.H. Li, X.R. Su, C.Y. Guo, Z. Wang, C.H. Jin,Y. Li,T.W. Li
Rapid and efficient growth is a major consideration and challenge for global mariculture. The differential growth rate of the sea cucumber, Apostichopus japonicus, has significantly hampered the total production of the industry. In the present study, forward and reverse suppression subtractive hybridization libraries were constructed and sequenced from a .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.20.4
- DOI:
- 10.4238/2013.August.20.4