Cytogenomics
RAPD and ISSR-assisted identification and development of three new SCAR markers specific for the Thinopyrum elongatum E (Poaceae) genome
Authors: G.H. Xu, W.Y. Su, Y.J. Shu, W.W. Cong, L. Wu and C.H. Guo
Diploid Thinopyrum elongatum, a wild relative of wheat, contains many agronomically desirable traits and has potential for increasing genetic variability and introducing desirable characters in this crop. Few molecular markers are available for rapid screening of T. elongatum genome segments in the wheat genetic background. We.. Read More»
- Genet. Mol. Res. 11(2):
- http://dx.doi.org/2012.June.29.7
- DOI:
- http://dx.doi.org/10.4238/2012.June.29.7
Vascular endothelial growth factor gene 1154 G/A, 2578 C/A, 460 C/T, 936 C/T polymorphisms and association with recurrent pregnancy losses
Authors: H. ��aml�±, B.��. Demir, A. ��zg�¶z, M.A. Atalay and G. Uncu
Vascular endothelial growth factor (VEGF) regulates endothelial cell proliferation, migration and differentiation. VEGF plays a critical role in angiogenesis during placenta formation. We investigated whether VEGF gene polymorphisms are associated with recurrent pregnancy loss. Thirty-eight women with recurrent pregnancy loss and 30 control women with liv.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.December.17.6
- DOI:
- 10.4238/2012.December.17.6
Low productivity of ribonucleotide reductase in Saccharomyces cerevisiae increases sensitivity to stannous chloride
Authors: T.S. Basso, C. Pungartnik and M. Brendel
Ribonucleotide reductase (RNR) of the yeast Saccharomyces cerevisiae is a tetrameric protein complex, consisting of two large and two small subunits. The small subunits Y2 and Y4 form a heterodimer and are encoded by yeast genes RNR2 and RNR4, respectively. Loss of Y4 in yeast mutant rnr4Δ can be compensated for by up-regulated expression of Y2, and.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr407
- DOI:
- 10.4238/vol7-1gmr407
Report of a chimeric origin of transposable elements in a bovine-coding gene
Authors: L.M. Almeida, M.E.J. Amaral, I.T. Silva, W.A. Silva Jr., P.K. Riggs and C.M. Carareto
Despite the wide distribution of transposable elements (TEs) in mammalian genomes, part of their evolutionary significance remains to be discovered. Today there is a substantial amount of evidence showing that TEs are involved in the generation of new exons in different species. In the present study, we searched 22,805 genes and reported the occurrence of.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr371
- DOI:
- 10.4238/vol7-1gmr371
Frequency of FMR1 premutation in individuals with ataxia and/or tremor and/or parkinsonism
Authors: A.H.O. Reis, A.C.S. Ferreira, K.B. Gomes, M.J.B. Aguiar, C.G. Fonseca, F.E. Cardoso, V.C. Pardini and M.R.S. Carvalho
A late onset neurological syndrome in carriers of premutation in FMR1 gene was recently described. The condition was named fragile-X-associated tremor/ataxia syndrome (FXTAS) and includes intentional tremor, cerebellar ataxia, parkinsonism, and cognitive deficit. We ascertained the contribution of FMR1 premutation to the phenotypes ataxia, tremor and/or p.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr357
- DOI:
- 10.4238/vol7-1gmr357
Genetic distance estimates among single cross hybrids and correlation with specific combining ability and yield in corn double cross hybrids
Authors: M. Balestre, J.C. Machado, J.L. Lima, J.C. Souza and L. N�³brega Filho
The objective of the present study was to correlate the genetic distances (GD) of single cross hybrids with yield, heterosis and specific combining ability (SCA) in the double cross hybrid synthesis. For this, 10 single cross commercial hybrids were used from different companies, and all the possible double hybrids were synthesized by a complete dialell. .. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr403
- DOI:
- 10.4238/vol7-1gmr403
Size of the exon 1-CAG repeats of the androgen receptor gene employed as a molecular marker in the diagnosis of Turner syndrome in girls with short stature
Authors: C.C. Figueiredo, C. Kochi, C.A. Longui, M.N. Rocha, F. Richeti, N.M.A. Evangelista, L.E.P. Calliari and O. Monte
Turner syndrome (TS) is one of the most common chromosomal abnormalities among girls. Complete monosomy of X chromosome is responsible for almost 50% of all cases of TS, and mosaicism and X anomaly are detected in the other half. It has already been demonstrated that early diagnosis of these children allows appropriate growth hormone treatment with better.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr391
- DOI:
- 10.4238/vol7-1gmr391
Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil
Authors: J.M. Biselli, E.M. Goloni-Bertollo, B.L. Zampieri, R. Haddad, M.N. Eberlin and E.C. Pavarino-Bertelli
The aim of the present study was to investigate the effect of polymorphisms C677T and A1298C in the methylenetetrahydrofolate reductase (MTHFR) gene, A2756G in methionine synthase reductase (MTR) gene and A80G in reduced folate carrier 1 (RFC1) gene, and plasma homocysteine (Hcy), on the maternal risk for Down syndrome (DS). Seventy-two DS mothers and 194.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr388
- DOI:
- 10.4238/vol7-1gmr388
Rapid and inexpensive analysis of genetic variability in Arapaima gigas by PCR multiplex panel of eight microsatellites
Authors: I.G. Hamoy, E.J.M. Santos and S.E.B. Santos
The aim of the present study was the development of a multiplex genotyping panel of eight microsatellite markers of Arapaima gigas, previously described. Specific primer pairs were developed, each one of them marked with either FAM-6, HEX or NED. The amplification conditions using the new primers were standardized for a single reaction. The results obtain.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr394
- DOI:
- 10.4238/vol7-1gmr394
Correlation of polymorphism C3435T of the MDR-1 gene and the response of primary chemotherapy in women with locally advanced breast cancer
Authors: F.F.O. Rodrigues, R.E. Santos, M.B. Melo, M.A.L.G. Silva, A.L. Oliveira, R.L. Rozenowicz, L.B. Ulson and T. Aoki
Primary chemotherapy is a useful strategy for the treatment of locally advanced breast cancer and therefore allows in vivo evaluation of the action of cytotoxic drugs and the possibility of accomplishing conservative breast surgeries, as well as the early treatment of metastasis. Mechanisms of resistance to the drugs include the action of protein associat.. Read More»
- Genet. Mol. Res. 7(1):