Bioinformatics
Molecular conservation of the mammalian leptin protein
Authors: J.E. Gabriel and K.C.F. Lidani
In this study, we comparatively assessed multiple sequences of the leptin protein from different animal species to establish new insights into conservation degree of biological sequences and evolutionary biology among mammals using computational biology tools. First, amino acid sequences of the leptin protein from Homo sapiens (human, P41159), Sus scrofa .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.16.9
- DOI:
- 10.4238/2015.January.16.9
X-meeting - International Conference of the AB3C
Authors: Roberto M. Cesar-Jr., Marcelo Santoro, Vasco Azevedo
The present special issue of GMR includes selected papers from the X-meeting 2006, held in Fortaleza, CE, Brazil, together with the 14th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2006). Dr. Goran Neshich, EMPRAPA, chaired this seminal event for the Brazilian bioinformatics community, co.. Read More»
- Genet. Mol. Res. 6(4):
miRNApath: a database of miRNAs, target genes and metabolic pathways
Authors: A.O. Chiromatzo, T.Y.K. Oliveira, G. Pereira, A.Y. Costa, C.A.E. Montesco, D.E. Gras, F. Yosetake, J.B. Vilar, M. Cervato, P.R.R. Prado, R.G.C.C.L. Cardenas, R. Cerri, R.L. Borges, R.N. Lemos, S.M. Alvarenga, V.R.C. Perallis, D.G. Pinheiro, I.T. Silva, R.M. Brand?£o, M.A.V. Cunha, S. Giuliatti and W.A. Silva Jr
MicroRNAs (miRNAs) are small non-coding RNAs that regulate target gene expression and hence play important roles in metabolic pathways. Recent studies have evidenced the interrelation of miRNAs with cell proliferation, differentiation, development, and diseases. Since they are involved in gene regulation, they are intrinsicall.. Read More»
- Genet. Mol. Res. 6(4):
Proteinase inhibition using small Bowman-Birktype structures
Authors: Fernandez JH, Mello MO, Galgaro L, Tanaka AS, Silva-Filho MC and Neshich G
Bowman-Birk inhibitors (BBIs) are cysteine-rich and highly cross-linked small proteins that function as specific pseudosubstrates for digestive proteinases. They typically display a “double-headed” structure containing an independent proteinase-binding loop that can bind and inhibit trypsin, chymotrypsin and elasta.. Read More»
- Genet. Mol. Res. 6(4):
A framework for modeling of juxtacrine signaling systems
Authors: Rozante LCS, Gubitoso MD and Matioli SR
Juxtacrine signaling is intercellular communication, in which the receptor of the signal (typically a protein) as well as the ligand (also typically a protein, responsible for the activation of the receptor) are anchored in the plasma membranes, so that in this type of signaling the activation of the receptor depends on direct.. Read More»
- Genet. Mol. Res. 6(4):
On the characterization of energy networks of proteins
Authors: Veloso CJM, Silveira CH, Melo RC, Ribeiro C, Lopes JCD, Santoro MM and Meira Jr. W
The construction of a realistic theoretical model of proteins is determinant for improving the computational simulations of their structural and functional aspects. Modeling proteins as a network of non-covalent connections between the atoms of amino acid residues has shown valuable insights into these macromolecules. The ener.. Read More»
- Genet. Mol. Res. 6(4):
Effects of sample re-sequencing and trimming on the quality and size of assembled consensus sequences
Authors: Prosdocimi F, Lopes DAO, Peixoto FC, Mourao MM, Pacifico LGG, Ribeiro RA and Ortega JM
The production of nucleic acid sequences by automatic DNA sequencer machines is always associated with some base-calling errors. In order to produce a high-quality DNA sequence from a molecule of interest, researchers normally sequence the same besample many times. Considering base-calling errors as rare events, re-sequencing .. Read More»
- Genet. Mol. Res. 6(4):
Optimal clone identifier for genomic shotgun libraries: â??OC Identifier toolâ?
Authors: Cantao ME, Ferreira JE and Lemos EGM
In DNA microarray experiments, the gene fragments that are spotted on the slides are usually obtained by the synthesis of specific oligonucleotides that are able to amplify genes through PCR. Shotgun library sequences are an alternative to synthesis of primers for the study of each gene in the genome. The possibility of puttin.. Read More»
- Genet. Mol. Res. 6(4):
Evolutive and structural characterization of Nostoc commune iron-superoxide dismutase that is fit for modification
Authors: Y. Ma M. Lu J.-Y. Li Y. Qin X.-G. Gong
Superoxide dismutase (SOD) has extensive clinical applications for protecting organisms from toxic oxidation. In this study, the integrated iron-superoxide dismutase gene (fe-sod) coding sequence of Nostoc commune stain CHEN was cloned from genomic DNA and compared to sods from other reported algae. These analyses of immunology and phylogenetics indicated th.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.4.8
- DOI:
- 10.4238/2012.October.4.8
Predicted philogeny, secondary conformational structure, and epitope antigenicity of immunological sequences in poultry
Authors: L.J. Lara, A.P. Peconick, ??.J. Fassani, A.M.P. J?ºnior, P.R.B. Chalfun, D.L. Raymundo, T.A. Bar?§ante and J.M. de P. Bar?§ante
Poultry production is faced with different types of stresses that are responsible for issues of animal welfare as well as for economic losses. Moreover, the immunity decreases when animals are stressed. In silico analyses are important in reducing the cost and in increasing the accuracy of scientific results. A bioinformatics .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029423
- DOI:
- 10.4238/gmr16029423