Animal Genetics
Molecular characterization and expression patterns of insulin-like growth factor-binding protein genes in postnatal Nanjiang brown goats
Authors: S.Y. Zhan, L. Chen, L. Li, L.J. Wang, T. Zhong and H.P. Zhang
Insulin-like growth factor-binding proteins (IGFBPs) play a key role in modulating insulin-like growth factors (IGFs), and are considered candidate genes for growth traits in livestock. In this study, we identified the complete coding sequences of IGFBP-1 to -6 in the Nanjiang brown goat, and assessed gene tissue expression pa.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.22
- DOI:
- 10.4238/2015.October.16.22
Hypoxia induces dysregulation of local renin-angiotensin system in mouse Lewis lung carcinoma cells
Authors: L. Fan*, Y. Feng*, H.Y. Wan, L. Ni, Y.R. Qian, Y. Guo, Y. Xiang and Q.Y. Li
The renin-angiotensin system (RAS) influences cancer biology and is frequently dysregulated in malignancy. However, regulation of tumor local RAS remains poorly understood. Hypoxia is a hallmark of solid tumors and affects nearly every major aspect of cancer biology. Previous studies have shown that hypoxia can regulate RAS expression in somatic tissues a.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.12.19
- DOI:
- 10.4238/2014.December.12.19
Effect of pinacidil on rat ventricular myocytes during transient hypoxia and reperfusion
Authors: X.Y. Dong and F. Zhu
The aim of this study was to evaluate the cardioprotective effect of pinacidil postconditioning on rat hearts with transient hypoxia and reperfusion. An acute myocardial anoxia-reperfusion rat model was created by ligating coronary arteries for 10 min and subsequent reperfusion for 60 min. Twenty-four rats in 4 groups received different treatments: normal.. Read More»
- Genet. Mol. Res. 13(4):
Roles of GILZ in protein metabolism of L6 muscle cells exposed to serum from septic rats
Authors: J. Xiong1,2*, L. Xu1,2*, W.M. Qu1,2, Z.L. Li3, Z.H. Shang1,2, Y.H. Li1, S.H. Yang1,2 and Z.H. Yang1,2
Sepsis is a complex inflammatory response to infection, associating with dramatic metabolic disorders. Although the mechanisms of immune response during sepsis have been largely clarified, current studies rarely pay attention to the disordered protein metabolism in sepsis. In this study, L6 rat skeletal muscle cells treated with serum from septic rats wer.. Read More»
- Genet. Mol. Res. 13(4):
Detection of a novel single nucleotide polymorphism and imprinted status analysis of the Ras protein-specific guanine nucleotide-releasing factor 1 gene in domestic pigs
Authors: Y.Y. Ding, L.Y. Liu*, J. Zhou, X.D. Zhang, L. Huang, S.J. Zhang and Z.J. Yin
The aim of this study was to determine the imprinting status of the Ras protein-specific guanine nucleotide-releasing factor 1 (Rasgrf1) gene in domestic pigs. In this study, a 228-bp partial sequence located in exon 14 and a 193-bp partial sequence located in exon 1 of the Rasgrf1 gene in domestic pigs were obtained... Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.12.20
- DOI:
- 10.4238/2014.December.12.20
Association of a hypoxia-inducible factor-3�± gene polymorphism with superovulation traits in Changbaishan black cattle
Authors: Q. Deng, Y. Gao, H. Jiang, C.Z. Chen, C.H. Li, W.L. Yu, X. Chen and J.B. Zhang
This study was designed to examine a single nucleotide polymorphism (SNP) in the HIF-3α gene in three hundred Changbaishan black cattle using PCR-restriction fragment length polymorphism to determine whether there is an association between this SNP and superovulation. The cloning and sequencing results indicate that the polymorphism is due to a poin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.17
- DOI:
- 10.4238/2015.November.18.17
Analysis of ITS1 sequences and genetic relationships between populations of ridgetail white prawn, Exopalaemon carinicauda, in the East China Sea
Authors: X.Z. Zhang, X.Q. Cheng, Y.X. Yu, H. Shen and X.H. Wan
Internal transcribed spacer 1 (ITS1) sequences from wild-type Exopalaemon carinicauda (N = 124) from the East China Sea were amplified and sequenced. Sequences were polymorphic and ranged from 388 to 583 bp in length. The average content of GC in sequences was significantly higher than that of AT. Altogether, 604 mutant sites .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.20
- DOI:
- 10.4238/2015.October.9.20
Mitochondrial DNA lineages of Italian Giara and Sarcidano horses
Authors: L. Morelli1�, A. Useli1, D. Sanna1, M. Barbato1,2, D. Contu3, M. Pala4,5, M. Cancedda6 and P. Francalacci1
Giara and Sarcidano are 2 of the 15 extant native Italian horse breeds with limited dispersal capability that originated from a larger number of individuals. The 2 breeds live in two distinct isolated locations on the island of Sardinia. To determine the genetic structure and evolutionary history of these 2 Sardinian breeds, the first hypervariable segmen.. Read More»
- Genet. Mol. Res. 13(4):
Combination of high-intensity focused ultrasound irradiation and hydroxyapatite nanoparticle injection to injure normal goat liver tissue in vivo without costal bone incision
Authors: L. Liu1, Z. Xiao1, Y. Xiao1, Z. Wang2, F. Li2, M. Li1 and X. Peng1
The aims of this study were to evaluate the in vivo safety of intravenous nano-hydroxyapatite (nano-HA), to explore how nano-HA might influence the effects of high-intensity focused ultrasound (HIFU) on normal liver tissue, and to investigate whether intravenous nano-HA could enhance HIFU for hepatocellular carcinoma ablation in a goat model... Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.6
- DOI:
- 10.4238/2014.October.20.6
Effects of Mycoplasma pneumoniae infection on airway neurokinin-1 receptor expression in BALB/c mice
Authors: H. Zhang1, B. Wei2, Y.X. Shang1, X.Y. Jiao1, L. Wang1, M.B. He3, X.H. Han1 and G.Z. Wang3
The aim of this study was to establish a BALB/c mouse model of Mycoplasma pneumoniae (MP) infection and to explore the expression of neurokinin-1 receptor (NK1-R) in the trachea and lung tissue and changes in its relative content at different time points (on the 3rd, 7th, 14th, 21st, and 30th days after infection) in MP-infected BALB/c mice. Immunohistoch.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.8
- DOI:
- 10.4238/2014.October.20.8