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Association of a hypoxia-inducible factor-3α gene polymorphism with superovulation traits in Changbaishan black cattle

Author(s): Q. Deng, Y. Gao, H. Jiang, C.Z. Chen, C.H. Li, W.L. Yu, X. Chen and J.B. Zhang

This study was designed to examine a single nucleotide polymorphism (SNP) in the HIF-3α gene in three hundred Changbaishan black cattle using PCR-restriction fragment length polymorphism to determine whether there is an association between this SNP and superovulation. The cloning and sequencing results indicate that the polymorphism is due to a point mutation at the 278-bp position in the HIF-3α gene, resulting in 3 genotypes (AA, AB, and BB). Association analysis indicated that the polymorphism has a significant effect on the number of unfertilized embryos (NUE) (P < 0.05) in the cattle. Cattle with genotype BB had a higher NUE than those with genotype AA, but the difference in NUE between AB and AA or BB was not significant.