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Effects of Mycoplasma pneumoniae infection on airway neurokinin-1 receptor expression in BALB/c mice

Author(s): H. Zhang1, B. Wei2, Y.X. Shang1, X.Y. Jiao1, L. Wang1, M.B. He3, X.H. Han1 and G.Z. Wang3

The aim of this study was to establish a BALB/c mouse model of Mycoplasma pneumoniae (MP) infection and to explore the expression of neurokinin-1 receptor (NK1-R) in the trachea and lung tissue and changes in its relative content at different time points (on the 3rd, 7th, 14th, 21st, and 30th days after infection) in MP-infected BALB/c mice. Immunohistochemistry and Western blot analysis were performed to determine NK1-R expression in the trachea and lung tissue and changes in relative content in MP-infected BALB/c mice.