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Human Genetics   Research Article

Predominance of the A allele but no association of the KCNJ11 rs5219 E23K polymorphism with Type 2 Diabetes in a Nigerian population

Authors: Godwill Azeh Engwa, Friday Nweke Nwalo, Chosen E. Obi, Christie Onyia, Opeolu Oyejide Ojo Wilfred Fon Mbacham, Benjamin Ewa Ubi

Though the rs5219 E23K variant of the KCNJ11 gene is commonly known to be associated with Type 2 diabetes (T2D) in Caucasian and Asian populations, little or none of such findings have been revealed in Nigeria. Hence, this study was aimed to assess the relationship between E23K polymorphic variant of the KCNJ11 gene and T2D in.. Read More»

Genet. Mol. Res. 17(1):
gmr16039889
DOI:
10.4238/gmr16039889
Human Genetics   Research Article

Clinical features of diabetes mellitus cases complicated by Burkholderia pseudomallei septicemia

Authors: H.B. Quan, T.Y. Li, Y.Y. Gao and D.X. Chen

The aim of this study was to analyze the clinical characteristics of diabetes mellitus patients with Burkholderia pseudomallei septicemia and evaluate strategies of diagnosis and treatment. The clinical characteristics, diagnosis, treatment, and prognosis of 39 diabetes mellitus patients with B. pseudomallei septicemia were re.. Read More»

Genet. Mol. Res. 13(2):
2014.April.17.7
DOI:
10.4238/2014.April.17.7
Human Genetics   Research Article

Polymorphic variations in manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) genes contribute to the development of type 2 diabetes mellitus in the Chinese Han population

Authors: J.Y. Li, F. Tao, X.X. Wu, Y.Z. Tan, L. He and H. Lu

Impaired antioxidant defense increases the oxidative stress and contributes to the development of type 2 diabetes mellitus (T2DM). MnSOD and eNOS are important antioxidant enzymes. This aim of this study was to verify the association of MnSOD and eNOS tagSNPs with T2DM in a Chinese Han population. Four tagSNPs of MnSOD and eight tagSNPs of eNOS were detec.. Read More»

Genet. Mol. Res. 14(4):
2015.October.21.20
DOI:
10.4238/2015.October.21.20
Human Genetics   Research Article

Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients

Authors: F.J. Wei, C.Y. Cai, P. Yu, J. Lv, C. Ling, W.T. Shi, H.X. Jiao, B.C. Chang, F.H. Yang, Y. Tian, M.S. Li, Y.H. Wang, L. Zou, J.M. Shi, L.M. Chen and W.D. Li

Recent genome-wide association studies have identified many loci associated with type 2 diabetes mellitus (T2DM), hyperuricemia, and obesity in various ethnic populations. However, quantitative traits have been less well investigated in Han Chinese T2DM populations. We investigated the association between candidate gene single.. Read More»

Genet. Mol. Res. 14(4):
2015.November.30.25
DOI:
10.4238/2015.November.30.25
Cytogenomics   Research Article

Role of mitochondrial DNA variants and copy number in diabetic atherogenesis

Authors: M.C. Chien W.T. Huang P.W. Wang C.W. Liou T.K. Lin C.J. Hsieh S.W. Weng

Hyperglycemia-induced reactive oxygen species production can cause diabetes and its complications, including atherosclerosis. The role of mitochondrial DNA variants and mitochondrial copy number in the pathogenesis of diabetic atherogenesis is not well understood. We examined 36 diabetic patients who had undergone amputation for diabetic foot and seven non-d.. Read More»

Genet. Mol. Res. 11(3):
2012.September.17.4
DOI:
10.4238/2012.September.17.4
Human Genetics   Research Article

SLC30A8 (ZnT8) variations and type 2 diabetes in the Chinese Han population

Authors: J. Xu, J. Wang and B. Chen

In recent genome-wide association studies, variants in the SLC30A8 gene have been found to be associated with risk for type 2 diabetes. We examined a possible association of tag SNPs spanning SLC30A8 and their haplotypes with type 2 diabetes in the Chinese Han population. There were 1508 Chinese Han type 2 diabetes patients an.. Read More»

Genet. Mol. Res. 11(2):
dx.doi.org/2012.May.24.1
DOI:
dx.doi.org/10.4238/2012.May.24.1
Human Genetics   Research Article

Correlation between polymorphism of platelet alloantigen genes HPA-1-5 and type 2 diabetes complication by carotid atherosclerosis in a Chinese population

Authors: Y.H. Zhang, S.F. Xu, J. Zheng, H.S. Hong and L.M. Fan

We investigated the association between the polymorphism of human platelet alloantigen genes HPA-1-HPA-5 and the complication of type 2 diabetes mellitus (T2DM) by carotid atherosclerosis (CA) among Han people in Guiyang District, China. Ninety-nine T2DM patients were selected from the Affiliated Hospital of Guiyang Medical College and divided into a CA(+.. Read More»

Genet. Mol. Res. 14(2):
2015.May.4.19
DOI:
10.4238/2015.May.4.19
Medical Genetics   Research Article

Association of peroxisome proliferator-activated receptor-delta polymorphisms with sugar metabolism indices and tumor necrosis factor alpha level

Authors: X.J. Yu, B.L. Su, X.M. Wang, H.J. Feng and C.J. Jin

This study aims to investigate the association of peroxisome proliferator-activated receptor (PPAR) delta -87T/C polymorphism with several sugar metabolism indices and tumor necrosis factor α (TNF α) level. The body mass index (BMI), waist size, and levels of fasting plasma glucose, serum lipid, fasting insulin, TN.. Read More»

Genet. Mol. Res. 13(3):
2014.July.7.1
DOI:
10.4238/2014.July.7.1
Human Genetics   Research Article

Association of the FABP2 Ala54Thr polymorphism with type 2 diabetes, obesity, and metabolic syndrome: a population-based case-control study and a systematic meta-analysis

Authors: Y. Liu, G. Wu, L. Han, K. Zhao, Y. Qu, A. Xu and Q. Huang

Previous studies have reported associations between the functional FABP2 Ala54Thr (rs1799883) polymorphism and type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome in different populations with conflicting results. We investigated the association between the FABP2 Ala54Thr polymorphism and T2DM (235 cases, 431 controls), obesity (377 cases, 43.. Read More»

Genet. Mol. Res. 14(1):
2015.February.6.19
DOI:
10.4238/2015.February.6.19
Human Genetics   Research Article

Oligonucleotide microarray analysis reveals dysregulation of energy-related metabolism in insulin-sensitive tissues of type 2 diabetes patients

Authors: M. Wang, X.C. Wang, L. Zhao, Y. Zhang, L.L. Yao1, Y. Lin, Y.D. Peng and R.M. Hu

Impaired insulin action within skeletal muscle, adipose tissue, and the liver is an important characteristic of type 2 diabetes (T2D). In order to identify common underlying defects in insulin-sensitive tissues that may be involved in the pathogenesis of T2D, the gene expression profiles of skeletal muscle, visceral adipose ti.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.June.17.1
DOI:
http://dx.doi.org/10.4238/2014.June.17.1