Type 2 Diabetes
Effects of ginsenoside Rg1 on glucose metabolism and liver injury in streptozotocin-induced type 2 diabetic rats
Authors: W. Tian, L. Chen, L. Zhang, B. Wang, X.B. Li, K.R. Fan, C.H. Ai, X. Xia, S.D. Li, Y. Li
Type 2 diabetes mellitus (T2-DM) is a chronic metabolic disorder characterized by high blood glucose levels. T2-DM patients suffer from many complications, such as diabetic fatty liver and diabetic nephropathy. The liver, the pivotal organ involved in both glucose and lipid metabolism, is primarily damaged in T2-DM patients, e.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019463
- DOI:
- 10.4238/gmr16019463
Associations between genetic variants and the severity of metabolic syndrome in subjects with type 2 diabetes
Authors: Y.L. Chen, D. Pei, Y.J. Hung, C.H. Lee, F.C. Hsiao, C.Z. Wu,J.D. Lin, C.H. Hsu, J.B. Chang and C.H. Hsieh
Metabolic syndrome (MetS) includes obesity, dyslipidemia, elevated blood pressure, and dysglycemia. Subjects with type 2 diabetes (T2D) exhibit features of MetS. The etiology of MetS is complex, involving both environmental and genetic factors. In this study, we examined the role of specific candidate genetic variants on the severity of MetS in T2D subjec.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.10
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.10
Association between -1082G/A, -819C/T, and -592C/A genetic polymorphisms in IL-10 and risk of type 2 diabetes mellitus in a Chinese population
Authors: Q.Y. Dong, X.M. Liu, C.G. Liang, W.H. Du, Y.L. Wang, W.X. Li and G.Q. Gao
Type 2 diabetes mellitus is the most common form of endocrine disease in humans; genetic factors are known to contribute to the development of this disease. In this case-control study, we investigated the relationship between the -1082G/A, -819C/T, and -592C/A polymorphisms in interleukin 10 (IL-10) and the pathogenesis of typ.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038559
- DOI:
- 10.4238/gmr.15038559
Association of TLR2 and TLR4 non-missense single nucleotide polymorphisms with type 2 diabetes risk in a southern Chinese population: a case-control study
Authors: W.H. Huang, L.H. Nie, L.J. Zhang, L.P. Jing, F. Dong, M. Wang, N. Zhang, Y. Liu, B.H. Zhang, C. Chen, H.S. Lin, X.C. Wei, G. Yang and C.X. Jing
Toll-like receptors (TLRs), the triggers of the innate and adaptive immune responses, are involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Several studies have investigated the effects of genetic polymorphisms in TLR4 and TLR2, but they have yielded limited results. We investigated whether non-missense geneticpolymorphisms in the regulator.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.18
- DOI:
- 10.4238/2015.July.31.18
Genetic polymorphisms in extracellular superoxide dismutase Leu53Leu, Arg213Gly, and Ala40Thr and susceptibility to type 2 diabetes mellitus
Authors: Y.M. Yang, X.R. Xie and A.L. Jin
The most common type of endocrine disease is type 2 diabetes mellitus (T2DM); genetic factors contribute to the development to T2DM. In this study, we investigated the role of the Leu53Leu, Arg213Gly, and Ala40Thr polymorphisms in extracellular superoxide dismutase (EC-SOD) gene in the development of T2DM in a Chinese populati.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048418
- DOI:
- 10.4238/gmr15048418
CDKAL1 and type 2 diabetes: a global meta-analysis
Authors: M.A.S. Dehwah, M. Wang and Q.-Y. Huang
CDKAL1 (cyckin-dependent kinase 5 regulatory subunit-associated protein 1-like 1) has been shown to be associated with type 2 diabetes in various ethnic groups; however, contradictory results have been reported. We performed a comprehensive meta-analysis of 21 studies for rs7756992, 17 studies for rs7754840 and 10 studies for .. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr802
- DOI:
- 10.4238/vol9-2gmr802
Analysis of selected glutathione S-transferase gene polymorphisms in Malaysian type 2 diabetes mellitus patients with and without cardiovascular disease
Authors: A. Etemad, R. Vasudevan, A.F.A. Aziz, A.K.M Yusof, S. Khazaei, N. Fawzi, S. Jamalpour, M. Arkani, N.A. Mohammad and P. Ismail
Type 2 diabetes mellitus (T2DM) is believed to be associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress, and have been associated with cardiovascular disease (CVD). The present study assessed the .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15025845
- DOI:
- 10.4238/gmr.15025845
Meta-analysis of association of common variants in the KCNJ11-ABCC8 region with type 2 diabetes
Authors: L.J. Qin, Y. Lv and Q.Y. Huang
KCNJ11 (potassium inwardly rectifying channel, subfamily J, member 11) and ABCC8 (ATP-binding cassette, subfamily C (CFTR/MRP), member 8) have been studied for association with type 2 diabetes in various ethnic populations with contradictory results. We performed a comprehensive meta-analysis for KCNJ11 rs5219, rs5210, rs5215, and ABCC8 rs757110 to evalua.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.20.1
- DOI:
- 10.4238/2013.August.20.1
Lack of association of functional UCP2 -866G/A and Ala55Val polymorphisms and type 2 diabetes in the Chinese population based on a case-control study and a meta-analysis
Authors: L.J. Qin, J. Wen, Y.L. Qu and Q.Y. Huang
Uncoupling protein 2 (UCP2) is a mitochondrial transporter protein and can affect the function of β-cells. We investigated a possible association between functional UCP2 -866G/A and Ala55Val polymorphisms and type 2 diabetes in 715 Hubei Han Chinese. No significant association was found, either for the -866G/A polymorphism (allele, P = 0.254; genotyp.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.3.9
- DOI:
- 10.4238/2013.September.3.9
Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population
Authors: M.Y. Yu, P.Q. Zhao, X.H. Yan, B. Liu, Q.Q. Zhang, R. Wang, C.H. Ma, X.H. Liang, F.L. Zhu and L.F. Gao
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including the pancreas and lymphocytes, and it can selectively induce apoptosis in tumor cells but not in most normal cells. TRAIL plays critical roles in type 1 diabetes mellitus, and is involved in type 2 diabetes mellitus (T2DM). We recent.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.10.2
- DOI:
- 10.4238/2013.September.10.2