Type 2 Diabetes
Genetic polymorphisms of the TLR4 gene and their association with susceptibility to type 2 diabetes mellitus in the Chinese population
Authors: X.D. Fu, X.Q. Sun, H.Y. Wang, J.F. Guo, G.Z. Zhang and Q.H. Xu
Toll-like receptor 4 (TLR4) is potentially an important gene affecting the susceptibility to type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate whether genetic polymorphisms of the TLR4 gene are associated with T2DM susceptibility. This potential association was analyzed in 668 T2DM patients and 672 healthy controls by polymerase.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.13
- DOI:
- 10.4238/2013.September.19.13
Relationship between the polymorphisms in KCNQ1 and type 2 diabetes in Chinese Kazakh population
Authors: L.J. Cui, X.Y. Chang, L.Y. Zhu, G. Feng, T. Zhou, C.X. Zhang, K.Y. Chong and K. Sun
Recently genome-wide association studies on East Asian populations reported an association between diabetes and several single nucleotide polymorphisms (SNPs) in a 40-kb linkage disequilibrium block in intron 15 of KCNQ1. However, the association between KCNQ1 variants and type 2 diabetes mellitus (T2DM) in Chinese Kazakh popu.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027503
- DOI:
- 10.4238/gmr.15027503
Insulin receptor binding motif tagged with IgG4 Fc (Yiminsu) works as an insulin sensitizer to activate Akt signaling in hepatocytes
Authors: J. Wang, T. Zou, H.X. Yang, Y.Z. Gong, X.J. Xie, H.Y. Liu and D.F. Liao
Insulin resistance is a key feature of obesity and type 2 diabetes mellitus (T2DM). Interaction of insulin with the insulin receptor (IR) leads to both its auto-phosphorylation and phosphorylation of tyrosine residues on the IR substrate (IRS) proteins, initiating the activation of intracellular signaling cascades. The metabolic effects of IRS are known t.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.5
- DOI:
- 10.4238/2015.August.3.5
Serum YKL-40 levels are associated with type 2 diabetes mellitus in patients with obstructive sleep apnea syndrome
Authors: L. Sun, J.Y. Liu and L.R. Li
Patients with obstructive sleep apnea syndrome (OSAS) have an increased risk for type 2 diabetes mellitus (T2DM). It has been recently demonstrated that serum YKL-40 levels, also named as human cartilage glycoprotein 39, are elevated in T2DM patients. The aim of this study was to determine whether serum YKL-40 levels are associated with T2DM in patients w.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.15
- DOI:
- 10.4238/2015.August.3.15
Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil
Authors: C.M.A.R. Barros, A.P. Araujo-Neto, T.R. Lopes, M.A.L. Barros, F.J.N. Motta, R. Canalle, L.C.C. Nunes, J.A. Rey, R.R. Burbano, M.A. Lima-Barros, F.K.N. Yoshioka and G.R. Pinto
Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have dem.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.1
- DOI:
- 10.4238/2014.September.29.1
Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus
Authors: J. Wu, S.S. Hou, W. Wang, M. Yin, N. Cheng, L.L. Ge, J.J. Yin and J. Xu
The objective of this study was to investigate the mRNA expression of hepatic phosphoenolpyruvate carboxykinase (PEPCK) after gastric bypass surgery (GBS) in rats with type 2 diabetic mellitus (T2DM). Thirty-six male Goto-Kakizaki rats, aged 12 weeks, were randomly divided into the GBS, sham operation with diet restriction (SO), and sham operation alone (.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.22
- DOI:
- 10.4238/2015.December.14.22
High-resolution color doppler ultrasound examination and related risk factor analysis of lower extremity vasculopathy in type 2 diabetes patients
Authors: J. Xu,G. Wang,D. Fu,N. Su,L. Wang,F. Gao and N. Guo
This study aims to investigate the value of high-resolution color Doppler ultrasonography (HR-CDU) in the evaluation of lower-extremity vasculopathy (LEV) and its related risk factors in type 2 diabetes mellitus (T2DM) patients. Two hundred forty T2DM patients were selected, who underwent lower-extremity arterial HR-CDU. The patients were divided into the.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.8
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.8
Investigation into the association between NLRP3 gene polymorphisms and susceptibility to type 2 diabetes mellitus
Authors: S. Wang, F. Fang, W.B. Jin, X. Wang and X.S. Zheng
We conducted a case-control study to investigate the role of three common polymorphisms (rs10754558, rs7512998, and rs12137901) of the gene NLR family, pyrin domain containing 3 (NLRP3) in the development of type 2 diabetes mellitus (T2DM). Between May 2013 and May 2014, 385 patients with T2DM and 401 control subjects were enrolled in our study. Genotypin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.15
- DOI:
- 10.4238/2015.December.21.15
Association between matrix metallopeptidase 1 and type 2 diabetes mellitus coexisting with coronary heart disease in a Han Chinese population
Authors: Y.Z. Ma, Q.Y. Jiang and D.Q. Kong
Matrix metallopeptidase 1 (MMP-1) has been reported to be involved in the coexistence of type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). We sought to examine the association between the MMP-1 gene polymorphism and coexistence of T2DM and CHD in a Han Chinese population. We extracted genomic DNA from the perip.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027938
- DOI:
- 10.4238/gmr.15027938
Association between transcription factor 7-like 2 genetic polymorphisms and development of type 2 diabetes in a Chinese population
Authors: H.Y. Jia, Q.Z. Li and L.F. Lv
We conducted a hospital-based case-control study to evaluate the relationship between the transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism and type 2 diabetes mellitus risk in a Chinese population. Genotyping of TCF7L2 rs7903146 was carried out using the polymerase chain reaction-restriction fragment length polymo.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028223
- DOI:
- 10.4238/gmr.15028223