Type 2 Diabetes

Proliferation and differentiation of human osteoblasts from a type 2 diabetic patient in vitro

Authors: J. Li, C.Y. Liu, Y.F. Jiang, X.Z. Wei and J.U. Li

We investigated the proliferation and differentiation potential of human osteoblasts from a type 2 diabetic patient in vitro. Human osteoblasts were obtained from a healthy subject and a type 2 diabetic patient and were cultured in vitro using the tissue explant adherent method. Differences in cell morphology were observed under a phase contrast microscop.. Read More»

Genet. Mol. Res. 14(3):

http://dx.doi.org/2015.September.22.23

DOI:

http://dx.doi.org/10.4238/2015.September.22.23

Association between retinoid-X receptor-gamma genetic polymorphisms and diabetic retinopathy

Authors: C.-H. Hsieh, D. Pei, Y.-J. Hung and F.-C. Hsiao

Retinoid-X receptor (RXR) is one of the members of the nuclear hormone receptor superfamily. It forms heterodimers with many nuclear receptors, such as the peroxisome proliferative-activated receptor, which has been proposed to be involved in diabetic complications, including retinopathy. A recent study revealed that RXR-alpha.. Read More»

Genet. Mol. Res. 10(4):

2011.December.5.4

DOI:

10.4238/2011.December.5.4

Role of APN and TNF-�± in type 2 diabetes mellitus complicated by nonalcoholic fatty liver disease

Authors: X. Lin, Z. Zhang, J.M. Chen, Y.Y. Xu, H.R. Ye, J. Cui, Y. Fang,Y. Jin, D.R. Zhu and L. Yuan

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease caused by non-excessive alcohol consumption and is the most common cause of elevated levels of serum liver enzymes. We examined changes in adiponectin (APN) and tumor necrosis factor-a (TNF-a) in type 2 diabetes mellitus (T2DM) complicated by NAFLD and their relationships with insulin resis.. Read More»

Genet. Mol. Res. 14(2):

http://dx.doi.org/2015.April.10.1

DOI:

http://dx.doi.org/10.4238/2015.April.10.1

Associations between INSR and MTOR polymorphisms in type 2 diabetes mellitus and diabetic nephropathy in a Northeast Chinese Han population

Authors: A.N. Zhu, X.X. Yang, M.Y. Sun, Z.X. Zhang and M. Li1,

We explored the associations of INSR and mTOR, 2 key genes in the insulin signaling pathway, and the susceptibility to type 2 diabetes mellitus and diabetic nephropathy. Three single-nucleotide polymorphisms (SNPs) (rs1799817, rs1051690, and rs2059806) in INSR and 3 SNPs (rs7211818, rs7212142, and rs9674559) in mTOR were genotyped using the Sequenom MassA.. Read More»

Genet. Mol. Res. 14(1):

2015.March.13.9

DOI:

10.4238/2015.March.13.9

Promotive effect of comprehensive management on achieving blood glucose control in senile type 2 diabetics

Authors: S.-T. Yan, C.-X. Li, C.-L. Li, J. Li, Y.-H. Shao, Y. Liu, W.-W. Zhong, F.-S. Fang, B.-R. Sun and H. Tian

The aim of this study was to evaluate the control of blood glucose and glycosylated hemoglobin A1c (HbA1c) and its influencing factors, in elderly type 2 diabetic mellitus (T2DM) patients undergoing comprehensive management. After years of comprehensive prevention of and control measures for diabetes, elderly T2DM patients who were receiving long-term hea.. Read More»

Genet. Mol. Res. 14(2):

http://dx.doi.org/2015.April.10.16

DOI:

http://dx.doi.org/10.4238/2015.April.10.16

Evaluation of angiotensin-converting enzyme and adenosine deaminase polymorphisms in patients with type 2 diabetes mellitus

Authors: A.C.B. Domingos

Genet. Mol. Res. 9(2):

vol9-2ta030

DOI:

10.4238/vol9-2ta030

Staging of type 2 diabetes mellitus

Authors: S.L. Wu

There is currently no reported staging system for type 2 diabetes mellitus. Here, I attempted to stage type 2 diabetes mellitus in order to help clinicians, patients, and other interested individuals to effectively evaluate patient conditions... Read More»

Genet. Mol. Res. 14(1):

2015.March.20.22

DOI:

10.4238/2015.March.20.22

Calpain-10 gene polymorphisms and risk of type 2 diabetes mellitus in Mexican mestizos

Authors: V.J. Picos-C�¡rdenas , E. S�¡inz-Gonz�¡lez , A. Miliar-Garc�­a ,A. Romero-Zazueta, R. Quintero-Osuna, E. Leal-Ugarte,V. Peralta-Leal and J.P. Meza-Espinoza

The calpain-10 gene is expressed primarily in tissues important in glucose metabolism; thus, some of its polymorphisms have been associated with type 2 diabetes. In this study, we examined the association between the calpain-10 single-nucleotide polymorphism (SNP)-43, SNP-19, and SNP-63 and type 2 diabetes in Mexican mestizos. We included 211 patients and.. Read More»

Genet. Mol. Res. 14(1):

2015.March.27.6

DOI:

10.4238/2015.March.27.6

Upregulation of salivary �±2 macroglobulin in patients with type 2 diabetes mellitus

Authors: J.K. Feng, Y.F. Lu, J. Li, Y.H. Qi, M.L. Yi and D.Y. Ma

We investigated the expression of salivary α2-macroglobulin (α2-MG) in patients with type 2 diabetes mellitus (T2DM) to investigate its value for predicting damage to the salivary glands. A total of 116 patients with T2DM and 60 patients with impaired fasting glucose (IFG) were included in this study. Sixty health volunteers were enrolled as a.. Read More»

Genet. Mol. Res. 14(1):

2015.March.27.12

DOI:

10.4238/2015.March.27.12

Correlation of the TCF7L2 (rs7903146) polymorphism with an enhanced risk of type 2 diabetes mellitus: a meta-analysis

Authors: Y. Guan, L.H. Yan, X.Y. Liu, X.Y. Zhu, S.Z. Wang and L.M. Chen

Increasing evidence has demonstrated that a transcription factor 7-like 2 (TCF7L2) polymorphism (rs7903146) is significantly associated with type 2 diabetes mellitus (T2DM); however, limited sample size and variance of ethnicity in the studies investigating this association have led to conflicting reports regarding its role. Therefore, a comprehensive met.. Read More»

Genet. Mol. Res. 15(3):

gmr.15037969

DOI:

10.4238/gmr.15037969