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Rapid molecular diagnosis of the Gilbertâ??s syndrome-associated exon 1 mutation within the UGT1A1 gene
Authors: T.-Y. Hsieh, T.-Y. Shiu, N.-F. Chu, T.-Y. Chao, H.-C. Chu,W.-K. Chang, Y.-C. Chao and H.-H. Huang
Gilbert’s syndrome is suspected in patients with unconjugated hyperbilirubinemia caused by decreased activity of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene in the absence of abnormal liver function and hemolysis. The major genetic variants underlying Gilbert’s syndrome are TATA-box repeats of the promoter re.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.28.12
- DOI:
- 10.4238/2014.January.28.12
Identifying human disease genes: advances in molecular genetics and computational approaches
Authors: S.M. Bakhtiar, A. Ali, S.M. Baig, D. Barh, A. Miyoshi and V. Azevedo
The human genome project is one of the significant achievements that have provided detailed insight into our genetic legacy. During the last two decades, biomedical investigations have gathered a considerable body of evidence by detecting more than 2000 disease genes. Despite the imperative advances in the genetic understandin.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.23
- DOI:
- 10.4238/2014.July.4.23
Setup errors in cone-beam computed tomography and their effects on acute radiation toxicity in cervical cancer radiotherapy
Authors: S. Xin
This study aimed to evaluate cone-beam computed tomography setup errors during cervical cancer treatment and the effects of these errors on acute radiation toxicity and treatment efficacy. A total of 170 cervical cancer patients were randomly divided into image-guided radiation therapy (IGRT; 86 patients) and intensity-modulated radiation therapy (IMRT; 8.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.4
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.4
Chromosome instability in industrial strains of Saccharomyces cerevisiae batch cultivated under laboratory conditions
Authors: Lucena BTL, Silva-Filho EA, Coimbra MRM, Morais JOF, Simoes DA and Morais Jr. MA
Industrial ethanol fermentation is a complex microbiological process to which yeast cells must adapt for survival. One of the mechanisms for adaptation is thought to involve chromosome rearrangements. We found that changes in chromosome banding patterns measured by pulsed-field gel electrophoresis can also be produced in labor.. Read More»
- Genet. Mol. Res. 6(4):
Sequence analysis of the S1PR1 gene in river buffalo
Authors: N.B. Stafuzza1,2, B.C.M. Naressi1, M.M. Borges1 and M.E.J. Amaral-Trusty1
Recent developments in methodologies for genomic analyses have enabled a significant advance in understanding of the river buffalo genome. The S1PR1 gene has been mapped to buffalo chromosome 6 and bovine chromosome 3; this gene is of interest as it is a candidate for marbling in meat, an important economic trait. Here, we performed next generation sequen.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016363
- DOI:
- 10.4238/gmr.15016363
Genomic breeding value prediction for simple maize hybrid yield using total effects of associated markers, under different imbalance levels and environments
Authors: N.F. Cantelmo1, R.G. Von Pinho2 and M. Balestre3
The main objective of a maize breeding program is to generate hybrid combinations that are more productive than those pre-existing in the market. However, the number of parents, and consequently the number of crosses, increases so rapidly that the phenotypic evaluation of all the possible combinations becomes economically and technically infeasible. In th.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017232
- DOI:
- 10.4238/gmr.15017232
Characterization of nine transferred SSR markers in the tropical tree species Enterolobium contortisiliquum (Fabaceae)
Authors: P.A. Moreira S.A.S. Sousa F.A. Oliveira N.H. Ara?ºjo G.W. Fernandes D.A. Oliveira
Transfer of molecular markers is widely used in conservation genetic studies. We investigated the transferability of simple sequence repeat (SSR) markers developed for Enterolobium cyclocarpum to E. contortisiliquum, a tropical tree widely distributed in dry forests. A set of 9 evaluated SSR markers were amplified in E. contortisiliquum and the degree of .. Read More»
- Genet. Mol. Res. 11(4):
- 2012.August.17.11
- DOI:
- 10.4238/2012.August.17.11
Meta-analysis of constitutive QTLs for disease resistance in maize and its synteny conservation in the rice genome
Authors: L. Zhao, H.J. Liu, C.X. Zhang, Q.Y. Wang and X.H. Li
We collected data regarding 340 disease resistance quantitative trait loci (QTLs) from the maize genomic database (MaizeGDB). We constructed an integrated linkage map and analyzed this map by using the BioMercator 2.1 software with IBM2 2008 Neighbors genetic linkage map as a reference. We used a meta-analysis method to identify five â??consensusâ? sy.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.3.3
- DOI:
- 10.4238/2015.February.3.3
Identification of a Panax ginseng fruit fingerprint by HPLC-ESI-MS
Authors: H.F. Zhao1, F.F. Xu2, Y.T. Guo1 and H. Mi1
Over many years, parts of Panax ginseng (root and rhizome) have been identified and applied for medical purposes as traditional Chinese herbal medicine. Recently, research has indicated that ginseng fruit also contains similar compounds and is as rich as the other parts of the ginseng. This discovery may dramatically improve the efficient of outputs deriv.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017235
- DOI:
- 10.4238/gmr.15017235
Development of a novel set of microsatellite markers for Lippia alba (Verbenaceae)
Authors: D.S. Rocha, C.P. Santos, M.M. Bajay, J.B. Campos, A.F. Blank,J.B. Pinheiro and M.I. Zucchi
Microsatellite primers were developed and optimized for Lippia alba to characterize the L. alba germplasm bank of Universidade de S?£o Paulo. A genomic library enabled the design of 9 microsatellite primers. Six of the 9 primers yielded polymorphic products, which defined 2 groups in the bank. The data provide support to characterize germplasm banks, genet.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.3.4
- DOI:
- 10.4238/2015.February.3.4