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Acanthopanax senticosus attenuates inflammation in lipopolysaccharide-induced acute lung injury by inhibiting the NF-�ºB pathway

Authors: X.J. Fei, L.L. Zhu, L.M. Xia, W.B. Peng and Q. Wang

The dried roots of the plant Acanthopanax senticosus (AS) are used in traditional Oriental medicine and reportedly possess anti-inflammatory properties in vitro. However, whether AS has the same anti-inflammatory effect in vivo and the underlying mechanisms of this action remain unknown. In this study, we pretreated a mouse model of lipopolysaccharide-ind.. Read More»

Genet. Mol. Res. 13(4):

2014.December.12.16

DOI:

10.4238/2014.December.12.16

Genetic divergence of physiological-quality traits of seeds in a population of peppers

Authors: A.M.S. Pessoa, P.A. Barroso, E.R. do R�ªgo, G.D.A. Medeiros, R.L.A. Bruno and M.M. do R�ªgo

Brazil has a great diversity of Capsicum peppers that can be used in breeding programs. The objective of this study was to evaluate genetic variation in traits related to the physiological quality of seeds of Capsicum annuum L. in a segregating F2 population and its parents. A total of 250 seeds produced by selfing in the F1 g.. Read More»

Genet. Mol. Res. 14(4):

2015.October.16.15

DOI:

10.4238/2015.October.16.15

Purification, characterization, and heterologous expression of an antifungal protein from the endophytic Bacillus subtilis strain Em7 and its activity against Sclerotinia sclerotiorum

Authors: N.N. Wang, X.N. Gao, X. Yan, Z.P. Li, Z.S. Kang, L.L. Huang and Q.M. Han

An antifungal protein exhibiting a high activity against Sclero­tinia sclerotiorum in vivo was purified by ammonium sulfate precipitation, hydrophobic chromatography, and gel filtration chromatography from the culture filtrate of the endophytic Bacillus subtilis strain Em7. The protein was characterized as a β-1,3-1,4.. Read More»

Genet. Mol. Res. 14(4):

2015.November.30.27

DOI:

10.4238/2015.November.30.27

Molecular characterization of tumor necrosis factor receptor-associated factor 6 (TRAF6) in pearl oyster Pinctada martensii

Authors: Y. Jiao, Q.L. Tian, X.D. Du, Q.H. Wang, R.L. Huang, Y.W. Deng and S.L. Shi

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a key signaling adaptor molecule for tumor necrosis factor receptor superfamily and Toll-like receptor/interleukin-1 receptor family members. It signals the upstream receptors and is involved in a wide range of biological functions, such as immunity and bone metabolism. In this report, the TRAF.. Read More»

Genet. Mol. Res. 13(4):

2014.December.12.17

DOI:

10.4238/2014.December.12.17

Effects of gemcitabine on radiosensitization, apoptosis, and Bcl-2 and Bax protein expression in human pancreatic cancer xenografts in nude mice

Authors: Z.T. Shen, X.H. Wu, L. Wang, B. Li, X.X. Zhu

The aim of this study was to evaluate the radiosensitizing effects of gemcitabine towards human pancreatic cancer xenografts. A human pancreatic cancer xenograft model was established in nude mice, 36 of which were randomly divided into 6 treatment groups. Tumors were measured every 2 days, and the tumor volumes, growth delays.. Read More»

Genet. Mol. Res. 14(4):

2015.December.1.10

DOI:

10.4238/2015.December.1.10

SET8 expression is associated with overall survival in gastric cancer

Authors: X.L. Shi, Z.J. Guo, X.L. Wang, X.L. Liu, G.F. Shi

Genet. Mol. Res. 14(4):

2015.December.1.12

DOI:

10.4238/2015.December.1.12

LC-MS/MS: a rapid and simple new method for the determination of carbapenem �²-lactamases

Authors: J.L. Shen, Y.H. Xu and T.T. She

We investigated the application of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for pan-drug-resistant Acinetobacter baumannii (PDR-AB) with carbapenem resistance. Eight strains were randomly selected from 84 clinical isolates of PDR-AB strains obtained by the Kirby-Bauer and agar dilution methods. An efflux pump inhibition test was used to s.. Read More»

Genet. Mol. Res. 14(4):

2015.November.18.8

DOI:

10.4238/2015.November.18.8

Genetic variations in the UTR of genes related to molting in Eriocheir sinensis

Authors: X.G. Gao, H.S. Pu, C.B. He, X.B. Bao and W.D. Liu

Crab grows by periodic molting, which is controlled by molt-inhibiting hormone (MIH) and ecdysteroids. Untranslated regions (UTRs) play crucial roles in the posttranscriptional regulation of gene expression. In this study, using crab collected from Changjiang (Yangtze), Huanghe (Yellow), Liaohe, and Yalujiang rivers, 33 haplot.. Read More»

Genet. Mol. Res. 14(4):

2015.October.16.14

DOI:

10.4238/2015.October.16.14

Association between alcohol dehydrogenase 1C gene *1/*2 polymorphism and pancreatitis risk: a meta-analysis

Authors: F. Fang, J. Pan, G.H. Su, L.X. Xu, G. Li, Z.H. Li, H. Zhao and J. Wang

Numerous studies have focused on the relationship be­tween alcohol dehydrogenase 1C gene (ADH1C) *1/*2 polymorphism (Ile350Val, rs698, also known as ADH1C *1/*2) and pancreatitis risk, but the results have been inconsistent. Thus, we conducted a meta-anal­ysis to more precisely estimate this associati.. Read More»

Genet. Mol. Res. 14(4):

2015.November.30.2

DOI:

10.4238/2015.November.30.2

Association of interleukin gene polymorphisms with the risk of coronary artery disease

Authors: H.T. Yang, S.L. Wang, L.J. Yan, P. Qian and H.Y. Duanb

We conducted a case-control study to investigate the genetic variants Interleukin-1β(IL-1β) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) and -819C/T (rs1800871) in the development of coronary artery disease (CAD). A total of 410 individuals with CAD were enrol.. Read More»

Genet. Mol. Res. 14(4):

2015.October.16.16

DOI:

10.4238/2015.October.16.16