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Frequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia
Authors: A.A. Mansour, O.M. Saleh, T. Askar, A.M. Salim and A. Mergani
Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion varia.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.13
- DOI:
- 10.4238/2015.December.14.13
Absence of the BaeR protein leads to the early initiation of DNA replication in Escherichia coli
Authors: Y. Yao, Wunier and Morigen
Escherichia coli cells have dozens of two-component systems to sense and respond to various stimuli, and thereby cope with changing environments. BaeS/BaeR is one such two-component system, and it deals with a variety of envelope stresses. Interestingly, the ArcA/ArcB and TorS/TorR two-component systems are known to be associated with initiation of DNA re.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.16
- DOI:
- 10.4238/2015.December.14.16
Artesunate modulates expression of matrix metalloproteinases and their inhibitors as well as collagen-IV to attenuate pulmonary fibrosis in rats
Authors: Y. Wang, G. Huang, B. Mo and C. Wang
The aim of this study was to determine the effect of artesunate on extracellular matrix (ECM) accumulation and the expression of collagen-IV, matrix metalloproteinase (MMP), and tissue inhibitor of matrix metalloproteinase (TIMP) to understand the pharmacological role of artesunate in pulmonary fibrosis. Eighty Sprague-Dawley .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027530
- DOI:
- 10.4238/gmr.15027530
Association of MMP3 genotype with susceptibility to frozen shoulder: a case-control study in a Chinese Han population
Authors: Q. Xu, P.Y. Gai, H.L. Lv, G.R. Li and X.Y. Liu
Genetic factors may play an important role in frozen shoulder etiology, which may involve matrix metalloproteinase-3 (MMP3) gene polymorphisms. In this study, we examined single nucleotide polymorphisms in MMP3 for their association with frozen shoulder susceptibility in a Chinese Han population. The rs591058, rs650108, and rs679620 polymorphisms in the M.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017228
- DOI:
- 10.4238/gmr.15017228
Association between the PADI4 -94G/A polymorphism and rheumatoid arthritis: a meta-analysis in the Chinese population
Authors: H.X. Chang, B. Zhu, J.H. Yao, J. Wu, J. Wang and W. Sun
Although a number of studies have been conducted on the association between the peptidylarginine deiminase (PADI4) -94G/A polymorphism and rheumatoid arthritis (RA) in the Chinese population, the association remains elusive and controversial. To clarify the impact of the PADI4 -94G/A polymorphism on the risk of RA, a meta-analysis was performed in the Chi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017391
- DOI:
- 10.4238/gmr.15017391
A structured sparse regression method for estimating isoform expression level from multi-sample RNA-seq data
Authors: L. Zhang and X.J. Liu
With the rapid development of next-generation high-throughput sequencing technology, RNA-seq has become a standard and important technique for transcriptome analysis. For multi-sample RNA-seq data, the existing expression estimation methods usually deal with each single-RNA-seq sample, and ignore that the read distributions ar.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027670
- DOI:
- 10.4238/gmr.15027670
Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus
Authors: J. Wu, S.S. Hou, W. Wang, M. Yin, N. Cheng, L.L. Ge, J.J. Yin and J. Xu
The objective of this study was to investigate the mRNA expression of hepatic phosphoenolpyruvate carboxykinase (PEPCK) after gastric bypass surgery (GBS) in rats with type 2 diabetic mellitus (T2DM). Thirty-six male Goto-Kakizaki rats, aged 12 weeks, were randomly divided into the GBS, sham operation with diet restriction (SO), and sham operation alone (.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.22
- DOI:
- 10.4238/2015.December.14.22
Effects of HIF prolyl-hydroxylase-2 gene silencing on HCG-induced vascular endothelial growth factor expression in luteal cells
Authors: Z.H. Zhang, D.Z. Yin, X.S Pang and Z.C. Wang
Vascular endothelial growth factor (VEGF)-dependent angiogenesis plays a crucial role in corpus luteum formation and its functional maintenance in mammalian ovaries. We recently reported that activation of hypoxia-inducible factor (HIF)-1α signaling contributes to the regulation of VEGF expression in luteal cells (LCs) in response to human chorionic.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.2
- DOI:
- 10.4238/2015.December.14.2
Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer
Authors: W. Pan and H. Liao
The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ov.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.8
- DOI:
- 10.4238/2015.December.14.8
MicroRNA-26b inhibits osteosarcoma cell migration and invasion by down-regulating PFKFB3 expression
Authors: W.D. Zheng, F.L. Zhou and N. Lin
MicroRNAs regulate target gene expression and are involved in cell proliferation, apoptosis, differentiation, tumor invasion, and cancer stem cell regulation, among other processes. MicroRNA-26b (miR-26b) is closely related to tumor occurrence and development. In this study, we analyzed miR-26b expression in osteosarcoma tissue, its effect on Saos-2 osteo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.14
- DOI:
- 10.4238/2015.December.14.14