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MicroRNA-26b inhibits osteosarcoma cell migration and invasion by down-regulating PFKFB3 expression
Authors: W.D. Zheng, F.L. Zhou and N. Lin
MicroRNAs regulate target gene expression and are involved in cell proliferation, apoptosis, differentiation, tumor invasion, and cancer stem cell regulation, among other processes. MicroRNA-26b (miR-26b) is closely related to tumor occurrence and development. In this study, we analyzed miR-26b expression in osteosarcoma tissue, its effect on Saos-2 osteo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.14
- DOI:
- 10.4238/2015.December.14.14
Serum levels of PSA, ALP, ICTP, and BSP in prostate cancer patients and the significance of ROC curve in the diagnosis of prostate cancer bone metastases
Authors: R.J. Wei, T.Y. Li, X.C. Yang, N. Jia, X.L. Yang and H.B. Song
Bone metastasis is a common complication in prostate cancer patients that can cause bone pain and pathological fracture. This study tested serum levels of prostate specific antigen (PSA), alkaline phosphatase (ALP), bone sialoprotein (BSP), collagen type I pyridine crosslinking peptide (ICTP) in prostate cancer patients and th.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027707
- DOI:
- 10.4238/gmr.15027707
Immunohistochemical subtypes of diffuse large B-cell lymphoma in the head and neck region
Authors: J.M. Li,J. Hou,L. Li and Y. Wang
The objectives of this study were to detect immunohistochemical subtypes of diffuse large B-cell lymphoma (DLBCL) of the head and neck, to compare the Hans, Choi, and Tally algorithms and to examine the significance of protein expression in these algorithms. This study included 103 DLBCL patients at Sichuan Cancer Hospital between May 2010 and October 201.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.3
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.3
Mild hypothermia attenuates post-resuscitation brain injury through a V-ATPase mechanism in a rat model of cardiac arrest
Authors: J.C. Zhang, W. Lu, X.M. Xie, H. Pan, Z.Q. Wu and G.T. Yang
Although therapeutic hypothermia is an effective treatment for post-resuscitation brain injury after cardiac arrest (CA), the underlying mechanism remains unclear. Vacuolar H+-ATPase (V-ATPase) plays a key role in cellular adaption to a hypoxic environment. This study sought to evaluate the effect of mild hypothermia on V-ATPa.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027729
- DOI:
- 10.4238/gmr.15027729
An SduI polymorphism at intron 20 of the Chinese Holstein cow STAT4 gene and its effect on milk performance traits
Authors: X.M. Song, L. Zhang, J.F. Jiang, F.X. Shi and Y.Q. Jiang
The signal transducer and activator of transcription (STAT) genes are responsive to a wide range of cytokines, growth factors, and hormones, and thus control important biological processes. In humans, STAT4 mutations have been identified as genetic markers for rheumatoid arthritis, systemic lupus erythematosus, and primary Sjögren’s syndrome, w.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.13
- DOI:
- 10.4238/2013.May.13.13
HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk
Authors: S. Yan, Y.Z. Li, X.W. Zhu, C.L. Liu, P. Wang and Y.L. Liu
Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 and CASP-7 genes have been increasingly recognized as important regulators in the development of cancer. However, whether there is a specific association is still controversial. Ther.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.10
- DOI:
- 10.4238/2013.May.13.10
Co-culture of annulus fibrosus cells and bone marrow mesenchymal stem cells
Authors: Y. Xu,X.J. Zhang,L. Fang and T.B. Zhao
To investigate the effect on cell proliferation and extracellular matrix expression of annulus fibrosus (AF) cells when co-cultured with bone marrow mesenchymal stem cells (BMSCs). Primary isolated rabbit BMSCs and AF cells were cultured and harvested cells were placed into a 15-mL centrifugal tube co-culture system in a ratio of 2:1 (A group), 1:1 (B gro.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.7
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.7
CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription
Authors: Z. Su, G. Liu, X. Song, B. Liang, X. Chang and D. Huang
The dehydrogenase/reductase (SDR family) member 4 (DHRS4) gene is copied during mammalian evolution; therefore, while only one DHRS4 gene is expressed in the mouse genome, the gene cluster consists of two (DHRS4 and DHRS4L1) and three (DHRS4, DHRS4L2, and DHRS4L1) copies in chimpanzees and humans, respectively. In this study, .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027752
- DOI:
- 10.4238/gmr.15027752
Effect and mechanism of different ways of transplanting bone marrow mesenchymal stem cells in cardiopulmonary resuscitation in rats
Authors: L.L. Zhou, J.K. Liang, Q.M. Lin and Z.T. Huang
The effect and mechanism of different ways of transplanting bone marrow mesenchymal stem cells (MSCs) were explored for treating cardiopulmonary resuscitation in a rat model. Rats were divided into the cardiopulmonary resuscitation group (Group Con), the stereotactic lateral ventricle transplantation group (Group LV), the inte.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.7
- DOI:
- 10.4238/2014.September.29.7
Rapid discrimination between four seagrass species using hybrid analysis
Authors: M. Osathanunkul,P. Madesis,S. Ounjai,C. Suwannapoom and A. Jampeetong
Biological species are traditionally identified based on their morphological features and the correct identification of species is critical in biological studies. However, some plant types, such as seagrass, are taxonomically problematic and difficult to identify. Furthermore, closely related seagrass species, such as Halophila spp, form a taxonomically u.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.10
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.10