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Association of KCNJ11 with impaired glucose regulation in essential hypertension
Authors: Y. Wang, X.O. Zhou, Y. Zhang, P.J. Gao and D.L. Zhu
KCNJ11 is one of the candidate genes for type 2 diabetes, confirmed by genome wide association study, but there are little data on the relationship between KCNJ11 and impaired glucose regulation in essential hypertension patients. To identify the effect of E23K and I337V in the KCNJ11 gene on susceptibility to impaired glucose.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1127
- DOI:
- 10.4238/vol10-2gmr1127
Deep sequencing-based analysis of gene expression in bovine mammary epithelial cells after Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae infection
Authors: L. Xiu, Y.B. Fu, Y. Deng, X.J. Shi, Z.Y. Bian, A. Ruhan and X. Wang
The goal of this study was to characterize the transcriptome of primary bovine mammalian epithelial cells (pBMECs) and to identify candidate genes for response and resistance to Staphylococcus aureus (strain S108), Escherichia coli (strain E23), and Klebsiella pneumoniae (strain K96) infection. Using Solexa sequencing, approximately 4.9 million total sequ.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.15.1
- DOI:
- 10.4238/2015.December.15.1
Additional chromosomal abnormalities in core-binding factor acute myeloid leukemia
Authors: H.H. Hsiao, Y.C. Liu, H.C. Wang, Y.F. Tsai, C.H. Wu, S.F. Cho, J.F. Hsu, C.T. Huang, S.Y. Hsiao, C.P. Lee, C.S. Chang, S.F. Lin and T.C. Liu
Despite sharing a similar genetic abnormality, patients with core binding factor acute myeloid leukemia (CBF-AML), which is characterized by the presence of t(8;21) or inv(16)/t(16;16), show heterogeneous survival. Other molecular or cytogenetic factors are supposed to have an impact on the prognosis. We enrolled 24 CBF-AML patients to determine the impac.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.3
- DOI:
- 10.4238/2015.December.16.3
Lactic acid bacteria protect human intestinal epithelial cells from Staphylococcus aureus and Pseudomonas aeruginosa infections
Authors: S. Affhan, W. Dachang, Y. Xin and D. Shang
Staphylococcus aureus and Pseudomonas aeruginosa are opportunistic pathogens that cause nosocomial and food-borne infections. They promote intestinal diseases. Gastrointestinal colonization by S. aureus and P. aeruginosa has rarely been researched. These organisms spread to extra gastrointestinal niches, resulting in increasingly progressive infections. L.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.5
- DOI:
- 10.4238/2015.December.16.5
Development of novel microsatellite markers for conservation genetic studies of Vulpes vulpes (Canidae) by using next-generation sequencing method
Authors: J.-N. Yu,C.-U. Chung,K.H. Oh,B.-K. Lee and C.E. Lim
The red fox, Vulpes vulpes (Canidae), is the most widely distributed terrestrial carnivore worldwide, but this species is classified as endangered in Korea. In this study, we developed 25 polymorphic microsatellite markers that included 3-13 (mean = 6.32) alleles per locus using 22 red fox individuals. The most polymorphic locus was FR(59)TG (13 alleles) .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.12
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.12
Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil
Authors: C.R. Hoelzle, K.C.S.F. Magalh�£es, S.S. Carvalho, G.A. Santos, I.M. Maia, M.C.P.S. Sousa, J.S. Andrade-Filho, G.M.G. Cruz and R.T. Sim�µes
We examined whether the allelic and/or genotypic profile of locus -1562C/T of the matrix metalloproteinase (MMP-9) gene influences the protein expression levels of MMP-9 in patients with colorectal cancer (CRC) compared with controls. A total of 104 patients with CRC and 84 controls were evaluated. Peripheral blood was collected from both groups and DNA e.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017478
- DOI:
- 10.4238/gmr.15017478
Serotonin receptor 2C gene polymorphism associated with post-stroke depression in Chinese patients
Authors: W.K. Tang, N. Tang, C.D. Liao, H.J. Liang, V.C.T. Mok, G.S. Ungvari and K.S. Wong
The serotonin receptor 2C (HTR2C) gene has been shown to play a pivotal role in major depression. We examined the association between post-stroke depression (PSD) and polymorphism in HTR2C. A cohort of 223 patients with acute lacunar stroke admitted to the stroke unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months af.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.8
- DOI:
- 10.4238/2013.May.13.8
Factors that influence the test day milk yield and composition
Authors: F.G. Silva, L.F. Brito, R.A. Torres, J.I. Ribeiro J�ºnior, H.R. Oliveira, G.C. Caetano and M.T. Rodrigues
The objective of this research was to study the factors that influence the test day milk yield (TDMY) and percentages of protein, fat, lactose, and total dry extract obtained on test day. We evaluated 110,732 weekly milk production records from 1496 goats and 19,271 monthly milk constituent records from 1245 Alpine and Saanen goats, which were collected f.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.13.5
- DOI:
- 10.4238/2013.13.5
Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299
Authors: G.M. Chen,R.F. Ding,Y.D. Tan,X.B. Pan,G.M. Jiang,J.F. He,S.H. Lin,C. Liu and Y. Jia
Casein kinase 2 interacting protein 1 (CKIP1) is a specific interacting protein of the casein kinase 2 (CK2) α subunit, and, by binding CK2 and other proteins, functions as an adaptor to regulate a series of cellular functions. Previous studies suggested that CKIP1 might play an important role in regulating oncogenic activities. However, few studies.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.15
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.15
Agrobacterium-mediated transformation of Fusarium proliferatum
Authors: J. Bernardi-Wenzel, M.C. Quecine, J.L. Azevedo and J.A. Pamphile
Fusarium proliferatum is an important pathogen that is associated with plant diseases and primarily affects aerial plant parts by producing different mycotoxins, which are toxic to humans and animals. Within the last decade, this fungus has also been described as one of the causes of red root rot or sudden death syndrome in so.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027944
- DOI:
- 10.4238/gmr.15027944