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Effects of rifampicin on osteogenic differentiation and proliferation of human mesenchymal stem cells in the bone marrow
Authors: Z. Zhang, X. Wang, F. Luo, H. Yang, T. Hou, Q. Zhou, F. Dai, Q. He and J. Xu
This study was designed to investigate the effect of different concentrations of rifampicin on osteogenic differentiation and proliferation of mesenchymal stem cells (MSCs) in human bone marrow. Rifampicin treatment at 0, 4, 8, 16, 32, 64, and 128 mg/mL was applied throughout the whole process, from stromal cells purified from.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.25.3
- DOI:
- 10.4238/2014.August.25.3
Cytogenetics and morphology of two tortoise species of the genus Chelonoidis (Fitzinger, 1835) (Testudines)
Authors: T.L. Silva
The reptiles were reduced in number of species since the time that they ruled the earth until today. The tortoises have been poorly studied, particularly their morphological and cytogenetic features. We examined the species Chelonoidis carbonaria and C. denticulata, terrestrial tortoises representative of two contrasting biome.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2ta034
- DOI:
- 10.4238/vol10-2ta034
Association between ACP1 genetic polymorphism and favism
Authors: V. Polzonetti, V. Passini and N. Lucarini
An association between favism (a hemolytic reaction to consumption of fava beans), glucose-6-phosphate dehydrogenase deficiency (G6PD-) and acid phosphatase locus 1 (ACP1) phenotypes has been reported; the frequency of carriers of the pa and pc ACP1 alleles was found to be significantly higher in G6PD- individuals showing favi.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1062
- DOI:
- 10.4238/vol10-2gmr1062
Association of TSC gene variants and hypertension in Mongolian and Han populations
Authors: P.Y. Chang, L.G. Zhao and X.L. Su
We investigated a possible association between genetic variations in the thiazide-sensitive Na-Cl cotransporter (TSC) gene and essential hypertension (EH) in the Mongolian and Han ethnic groups in Inner Mongolia. Our study included 385 unrelated Mongolian herdsmen and 523 Han farmers. Nine tagSNPs of TSC were identified from t.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1227
- DOI:
- 10.4238/vol10-2gmr1227
Development of a cassava core collection based on single nucleotide polymorphism markers
Authors: E.J. Oliveira, C.F. Ferreira, V.S. Santos and G.A.F. Oliveira
Single nucleotide polymorphism (SNP) markers were used in the largest cassava (Manihot esculenta Crantz) germplasm collection from Brazil to develop core collections based on the maximization strategy. Subsets with 61, 64, 84, 128, 256, and 384 cassava accessions were selected and named PoHEU, MST64, PoRAN, MST128, MS.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.25.11
- DOI:
- 10.4238/2014.August.25.11
Genetic assessment of the Atlantic Forest bristle porcupine, Chaetomys subspinosus (Rodentia: Erethizontidae), an endemic species threatened with extinction
Authors: C.G. Oliveira, R.A. Martinez, G.A.F. Gin�©, D.M. Faria and F.A. Gaiotto
The bristle-spined porcupine, Chaetomys subspinosus, an endemic rodent from Atlantic Forest, was considered to be abundant in the recent past, but population reductions due to habitat loss and expansion of human activities caused this species to be included in the “vulnerable” category of the World Conservation Uni.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1039
- DOI:
- 10.4238/vol10-2gmr1039
Genetic control and estimation of genetic parameters for seed-coat darkening of carioca beans
Authors: F.C. Silva, P.G.S. Melo, H.S. Pereira and L.C. Melo
The maintenance of the light color of the grains of carioca beans is a requirement for the development of new cultivars of common beans because it enables the storage of grains for long periods so that they may be traded at a proper opportunity. Crosses of cultivar BRSMG Madrepérola, which presents slow grain darkening,.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.25.12
- DOI:
- 10.4238/2014.August.25.12
A modified acidic approach for DNA extraction from plant species containing high levels of secondary metabolites
Authors: M.M. Cavallari, M.V.B.M. Siqueira, T.M. Val, J.C. Pavanelli, M. Monteiro, C. Grando, J.B. Pinheiro, M.I. Zucchi and M.A. Gimenes
Purified genomic DNA can be difficult to obtain from some plant species because of the presence of impurities such as polysaccharides, which are often co-extracted with DNA. In this study, we developed a fast, simple, and low-cost protocol for extracting DNA from plants containing high levels of secondary metabolites. This pro.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.25.13
- DOI:
- 10.4238/2014.August.25.13
Relationship between the cholesterol ester transfer protein TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease
Authors: J. Li, L. Zhang, N.Z. Xie, B. Deng2, L.X. Lv and L.Q. Zheng
This study aimed to investigate the relationship between the cholesterol ester transfer protein (CETP) gene TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease. Two hundred eighty-eight patients were divided into a control group, an acute coronary syndrome (A.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.24.21
- DOI:
- 10.4238/2014.March.24.21
Lack of association of variants of the renal salt reabsorption-related genes SLC12A3 and ClC-Kb and hypertension in Mongolian and Han populations in Inner Mongolia
Authors: P.Y. Chang, X.G. Zhang and X.L. Su
Abnormalities in renal sodium chloride and water reabsorption play important roles in the development of hypertension. Mutations in the genes involved in renal sodium chloride reabsorption can affect blood pressure. Recently, the R904Q variant of the sodium/chloride transporters, member 3 (SLC12A3) gene and the T481S variant o.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1165
- DOI:
- 10.4238/vol10-2gmr1165