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Association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai population
Authors: S. Honsawek, B. Deepaisarnsakul, A. Tanavalee, P. Yuktanandana, P. Bumrungpanichthaworn, S. Malila and N. Saetan
Osteoarthritis is a chronic progressive degenerative joint disease characterized by age-related regressive change in articular cartilage. A single nucleotide polymorphism has been described at position -174 of the interleukin-6 (IL-6) promoter region, leading to three possible genotypes, GG, GC, and CC. We investigated a possi.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1161
- DOI:
- 10.4238/vol10-3gmr1161
Isolation and characterization of 19 polymorphic microsatellite loci from the topmouth gudgeon, Pseudorasbora parva
Authors: C. Zeng, Y. Gul, K. Yang, L. Cui, W.-M. Wang and Z.-X. Gao
The Asiatic topmouth gudgeon, Pseudorasbora parva, is recognized as one of the most invasive fish species in many countries outside of Asia. We isolated and characterized 19 microsatellite loci from P. parva. The polymorphism of these 19 loci was tested on 40 individuals of P. parva sampled from a wild population located in Ez.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1477
- DOI:
- 10.4238/vol10-3gmr1477
Application of RNA-seq to reveal the transcript profile in bacteria
Authors: A.C. Pinto, H.P. Melo-Barbosa, A. Miyoshi, A. Silva and V. Azevedo
The large number of microbial genomes deposited in databanks has opened the door for in-depth studies of organisms, including post-genomics investigations. Thanks to new generation sequencing technology, these studies have made advances that have lead to extraordinary discoveries in bacterial transcriptomics. In this review, w.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1554
- DOI:
- 10.4238/vol10-3gmr1554
Effects of sodium lactate Ringerâ��s injection on transfection of human protein kinase C-�± antisense oligonucleotide in A549 lung cancer cells
Authors: Z.H. Wang, W.W. Sun, Y.L. Han and Z. Ma
In the present study, we evaluated the effects of four solutions [Dulbecco’s modified Eagle’s medium (DMEM), sodium lactate Ringer’s injection (SLRI), phosphate-buffered saline (PBS), and NaCl] on the transfection of the human protein kinase C-a antisense oligonucleotide (PKC-a ASO) aprinocarsen in human lung carcinoma A549 cells. Specif.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037650
- DOI:
- 10.4238/gmr.15037650
Activation of Src tyrosine kinase in esophageal carcinoma cells in different regulatory environments and corresponding occurrence mechanism
Authors: Z.S. Yu, X.H. Song, H.M. Gan, D.Z. Geng and J. Yang
This study aims at observing the expression of activated Src tyrosine kinase in esophageal squamous cell carcinoma (ESCC), and exploring the relationship of Src tyrosine kinase with the occurrence and progression of ESCC. Immunohistochemistry, immunofluorescence, and immunoblotting are employed to investigate the expression of Src tyrosine kinase in the E.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038026
- DOI:
- 10.4238/gmr.15038026
Dynamic QTL analysis of seed reserve utilization in sh2 sweet corn germination stages
Authors: X.X. Cheng, S. He1 and G.H. Geng
In this study, dynamic quantitative trait loci (QTL) were mapped in a recombinant inbred line (F2:4) population derived from a BF3109 x Q267 cross. This was done during the unconditional (4, 7, and 10 days) and conditional (0 to 4, 4 to 7, and 7 to 10 days) germination stages in sh2 sweet corn. The values of seedling dry weight, weight of mobilized seed r.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038183
- DOI:
- 10.4238/gmr.15038183
Investigation of the role of XRCC1 genetic polymorphisms in the development of gliomas in a Chinese population
Authors: S.C. Fan, J.G. Zhou and J.Z. Yin
We conducted a study in a Chinese Han population to investigate the role of XRCC1 gene polymorphisms (Arg399Gln and Arg194Trp) with a risk of susceptibility to gliomas. Samples from 115 patients with gliomas and 228 control subjects were consecutively collected between March 2012 and December 2014. Genotype analysis of XRCC1 Arg399Gln and Arg194Trp was pe.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038268
- DOI:
- 10.4238/gmr.15038268
Correlation of VCAM-1 expression in serum, cord blood, and placental tissue with gestational hypertension associated with fetal growth restriction in women from Xingtai Hebei, China
Authors: H.G. Zhang, W. Guo, H.F. Gu, S.B. Chen, J.Q. Wang, Z.X. Qiao, H.S. Ma and S.X. Geng
The aim of this study was to investigate the expression of vascular adhesion molecule (VCAM)-1 in the maternal serum, cord blood, and placental tissue of pregnant women from Xingtai, Hebei, with gestational hypertension (GH) combined with fetal growth restriction (FGR). A total of 108 patients with GH combined with FGR (GH-FGR), 60 patients with GH alone .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038274
- DOI:
- 10.4238/gmr.15038274
Identification of key biomarkers involved in osteosarcoma using altered modules
Authors: Z.Z. Liu, S.T. Cui, B. Tang, Z.Z. Wang and Z.X. Luan
The aim of this study was to screen for key biomarkers of osteosarcoma (OS) by tracking altered modules. Protein-protein interaction (PPI) networks of OS and normal groups were constructed and re-weighted using the Pearson correlation coefficient (PCC), respectively. The condition-specific modules were explored from OS and normal PPI networks using a cliq.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038277
- DOI:
- 10.4238/gmr.15038277
Assessing the association between EFEMP1 rs3791679 polymorphism and risk of glioma in a Chinese Han population
Authors: N. Jiang, Y.P. Peng, X.Y. Wang, C.W. Dou and W.M. He
In this study, we assessed the association between the EFEMP1 rs3791679 polymorphism and glioma risk in a Chinese Han population. A total of 94 glioma patients and 206 healthy controls who conformed to the inclusion and exclusion criteria were recruited from Baogang Hospital between March 2012 and October 2014. The EFEMP1 rs3791679 gene polymorphism was a.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038279
- DOI:
- 10.4238/gmr.15038279