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Boning up on mutations: assessing the significance of candidate disease-causing DNA sequence variation

Authors: R. Dalgleish

Genet. Mol. Res. 10(3):

vol10-3gmr1353

DOI:

10.4238/vol10-3gmr1353

Genetic diversity in natural populations of mangaba in Sergipe, the largest producer State in Brazil

Authors: A.N.R. Soares, M.F. Vit�?³ria, A.L.S. Nascimento, A.S. Ledo, A.R.C. Rabbani and A.V.C. Silva

Mangaba (Hancornia speciosa Gomes) is found in areas of coastal tablelands in the Brazilian Northeast and Cerrado regions. This species has been subjected to habitat fragmentation that is mainly due to human activity, and requires conservation strategies. The aim of this study was to analyze the structure and inter- and intrapopulation genetic diversity o.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038624

DOI:

10.4238/gmr.15038624

Statistical analyses of conserved features of genomic islands in bacteria

Authors: F.-B. Guo, Z.-K. Xia, W. Wei and H.-L. Zhao

We performed statistical analyses of five conserved features of genomic islands of bacteria. Analyses were made based on 104 known genomic islands, which were identified by comparative methods. Four of these features include sequence size, abnormal G+C content, flanking tRNA gene, and embedded mobility gene, which are frequent.. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.March.17.6

DOI:

http://dx.doi.org/10.4238/2014.March.17.6

Defective eyelid leading edge cell migration in C57BL/6-corneal opacity mice with an â�?�?eye open at birthâ�? phenotype

Authors: L.C. Wu, C. Liu, M.R. Jiang ,Y.M. Jiang, Q.H. Wang, Z.Y. Lu, S.J. Wang, W.L. Yang and Y.X. Shao

Development of the eyelid requires coordination of the cellular processes involved in proliferation, cell size alteration, migration, and cell death. C57BL/6J-corneal opacity (B6-Co) mice are mutant mice generated by the administration of N-ethyl-N-nitrosourea (100 mg/kg). They exhibit the eyelids open at birth phenotype, abnormal round cell shape from ti.. Read More»

Genet. Mol. Res. 15(3):

gmr.15036741

DOI:

10.4238/gmr.15036741

Whole exome sequencing implicates PTCH1 and COL17A1 genes in ossification of the posterior longitudinal ligament of the cervical spine in Chinese patients

Authors: W. Wei1, H.-L. He, C.-Y. Chen, Y. Zhao, H.L. Jiang, W.-T. Liu, Z.F. Du, X.-L. Chen, S.Y. Shi, and X.N. Zhang

Ossification of the posterior longitudinal ligament (OPLL) of the cervical spine is a complex multifactorial disease. Patients with OPLL commonly present with symptoms in their 40s or 50s. The genetic basis of OPLL remains poorly understood. Exome capture combined with massively parallel DNA sequencing has been proposed as an .. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.March.17.7

DOI:

http://dx.doi.org/10.4238/2014.March.17.7

ChromaPipe: a pipeline for analysis, quality control and management for a DNA sequencing facility

Authors: T.D. Otto, E.A. Vasconcellos, L.H.F. Gomes, A.S. Moreira,W.M. Degrave, L. Mendon�?§a-Lima and M. Alves-Ferreira

Optimizing and monitoring the data flow in high-throughput sequencing facilities is important for data input and output, for tracking the status of results for the users of the facility, and to guarantee a good, high-quality service. In a multi-user system environment with different throughputs, each user wants to access his/h.. Read More»

Genet. Mol. Res. 7(3):

vol7-3x-meeting04

DOI:

10.4238/vol7-3x-meeting04

Polymorphisms in the bone morphogenetic protein 15 gene and their effect on sperm quality traits in Chinese Holstein bulls

Authors: L.P. Sun, Y.P. Song, Q.Z. Du, L.W. Song, Y.Z. Tian, S.L. Zhang,G.H. Hua and L.G. Yang

Bone morphogenetic protein 15 (BMP-15) expression has been detected in the testis, but its roles in this organ has not been well elucidated. We evaluated polymorphisms of the BMP-15 gene by PCR-SSCP and PCR-RFLP in 212 Chinese Holstein bulls, and investigated possible associations with sperm quality traits, including semen vol.. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.March.17.8

DOI:

http://dx.doi.org/10.4238/2014.March.17.8

A fully resolved consensus between fully resolved phylogenetic trees

Authors: Jos�?© Augusto Amgarten Quitzau and Jo�?£o Meidanis

Nowadays, there are many phylogeny reconstruction methods, each with advantages and disadvantages. We explored the advantages of each method, putting together the common parts of trees constructed by several methods, by means of a consensus computation. A number of phylogenetic consensus methods are already known. Unfortunatel.. Read More»

Genet. Mol. Res. 5(1):

White mold resistance-associated quantitative trait loci in the Jalo x Small White common bean population

Authors: D.A. Souza, M. Balestre, A.K.A. Pamplona, M.E. Leite, J.A. Dias and J.B. Santos

We aimed to identify simple sequence repeat (SSR) markers linked to quantitative trait loci (QTLs) associated with white mold resistance in a segregating population derived from a cross between common bean cultivars Jalo and Small White, in the Southern State of Minas Gerais. Parents were crossed to obtain the F2 generation of 190 plants. From these, F2:3.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038724

DOI:

10.4238/gmr.15038724

Gene networks as a tool to understand transcriptional regulation

Authors: Diogo Fernando Veiga, F�?¡bio Fernandes da Rocha Vicente and Gustavo Bastos

Gene regulatory networks, or simply gene networks (GNs), have shown to be a promising approach that the bioinformatics community has been developing for studying regulatory mechanisms in biological systems. GNs are built from the genome-wide high-throughput gene expression data that are often available from DNA microarray expe.. Read More»

Genet. Mol. Res. 5(1):