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A comparative analysis of highly conserved sex-determining genes between Apis mellifera and Drosophila melanogaster
Authors: Alexandre S. Cristino, Adriana Mendes do Nascimento, Luciano da Fontoura Costa and Zil�¥ Luz Paulino Sim�”es
A comparison of the most conserved sex-determining genes between the fruit fly, Drosophila melanogaster, and the honey bee, Apis mellifera, was performed with bioinformatics tools developed for computational molecular biology. An initial set of protein sequences already described in the fruit fly as participants of the sex-det.. Read More»
- Genet. Mol. Res. 5(1):
New strategy to detect single nucleotide polymorphisms
Authors: Miguel Galves, Jos�© Augusto Amgarten Quitzau and Zanoni Dias
A great effort has been made to identify and map a large set of single nucleotide polymorphisms. The goal is to determine human DNA variants that contribute most significantly to population variation in each trait. Different algorithms and software packages, such as PolyBayes and PolyPhred, have been developed to address this .. Read More»
- Genet. Mol. Res. 5(1):
Conservation implications of the genetic diversity of Gymnospermium microrrhynchum in Korea
Authors: S.H. Lee, M.H. Yeon and J.K. Shim
Gymnospermium microrrhynchum (Berberidaceae) is an ephemeral perennial herb with a limited distributional range in the Baekdudaegan mountain areas of the Korean Peninsula, and is designated a rare plant by the Korean Forest Service. Information about its genetic variation and structure is important for developing successful co.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048843
- DOI:
- 10.4238/gmr15048843
Building multiple sequence alignments with a flavor of HSSP alignments
Authors: Roberto Hiroshi Higa, Sergio Aparecido Braga da Cruz, Paula Regina Kuser, Michel Eduardo Beleza Yamagishi, Renato Fileto, Stanley Robson de Medeiros Oliveira, Ivan Mazoni, Edgard Henrique dos Santos, Adauto Luiz Mancini and Goran Neshich
Homology-derived secondary structure of proteins (HSSP) is a well-known database of multiple sequence alignments (MSAs) which merges information of protein sequences and their threedimensional structures. It is available for all proteins whose structure is deposited in the PDB. It is also used by STING and JavaProtein Dossier .. Read More»
- Genet. Mol. Res. 5(1):
Genetic structure of the threatened Dipterocarpus costatus populations in lowland tropical rainforests of southern Vietnam
Authors: N.M. Duc, V.D. Duy, B.T.T. Xuan, B.V. Thang, N.T.H. Ha and N.M. Tam
Dipterocarpus costatus is an endangered species restricted to the lowland forests of southern Vietnam. Habitat loss and over-exploitation of D. costatus wood are the major threats to this species. We investigated the level of genetic variability within and among populations of D. costatus in order to provide guidelines for the.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048821
- DOI:
- 10.4238/gmr15048821
Gene Class Expression: analysis tool of Gene Ontology terms with gene expression data
Authors: Gislaine S.P. Pereira, Rodrigo M. BrandĂ?ÂŁo, Silvana Giuliatti, Marco A. Zago and Wilson A. Silva Jr.
Serial analysis of gene expression (SAGE) technology produces large sets of interesting genes that are difficult to analyze directly. Bioinformatics tools are needed to interpret the functional information in these gene sets. We present an interactive web-based tool, called Gene Class, which allows functional annotation of SAG.. Read More»
- Genet. Mol. Res. 5(1):
SpotWhatR: a user-friendly microarray data analysis system
Authors: Tie Koide, Silvia M. Salem-Izacc, Suely L. Gomes and Ricardo Z.N. VĂ?ÂȘncio
SpotWhatR is a user-friendly microarray data analysis tool that runs under a widely and freely available R statistical language (http://www.r-project.org) for Windows and Linux operational systems. The aim of SpotWhatR is to help the researcher to analyze microarray data by providing basic tools for data visualization, normali.. Read More»
- Genet. Mol. Res. 5(1):
Analysis of ELOVL4 and PRPH2 genes in Turkish Stargardt disease patients
Authors: H. Bardak, M. Gunay, Y. Er�§al�±k, Y. Bardak, H. Ozbas, O. Bagci,A. Ayata, M. S�¶nmez and C. Alag�¶z
Stargardt disease (STGD) is an inherited genetic eye condition involving bilateral macular dystrophy leading to progressive central vision loss. It is the most common form of autosomal recessive juvenile macular dystrophy. In this study, ELOVL4 and PRPH2 genes were analyzed in 30 STGD probands for genetic variations using next.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048774
- DOI:
- 10.4238/gmr15048774
Target fishing of glycopentalone using integrated inverse docking and reverse pharmacophore mapping approach
Authors: A.B. Gurung, M.A. Ali, A. Bhattacharjee, K.M. Al-Anazi, M.A. Farah, F.M. Al-Hemaid, F.M. Abou-Tarboush, J. Lee, S.Y. Kim and F.S.M. Al-Anazi
Glycopentalone isolated from Glycosmis pentaphylla (family Rutaceae) has cytotoxic and apoptosis inducing effects in various human cancer cell lines; however, its mode of action is notknown. Therefore, target fishing of glycopentalone using a combined approach of inverse docking and reverse pharmacophore mapping approach was used to identify potential tar.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038544
- DOI:
- 10.4238/gmr.15038544
PTGS2 gene polymorphism -765G>C is associated with coronary artery disease: a meta-analysis
Authors: C.-L. Xuan, W. Yan, L. Xuan and R.-H. Xu
Previous studies focusing on the association of PTGS2 polymorphism -765G>C with coronary artery disease (CAD) have failed to reach the same conclusion. In the present study, we performed a meta-analysis to systematically summarize the possible association between PTGS2 polymorphism -765G>C and the risk of CAD. We conduct.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.14.10
- DOI:
- http://dx.doi.org/10.4238/2014.January.14.10