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TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese
Authors: X.M. Xu, M. Ding, H. Pang and B.J. Wang
In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nu.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.12.1
- DOI:
- http://dx.doi.org/10.4238/2014.March.12.1
Effect of polymorphisms in interleukin-18 gene on the susceptibility to coronary artery disease in a Chinese population
Authors: J.B. Ma, L. Chen, B. Gao and J. Xu
Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048708
- DOI:
- 10.4238/gmr15048708
Structural and biochemical characteristics of chitin-binding protein SeCBP66 from Spodoptera exigua (H�¼bner)
Authors: D. Zhao, B. Liu, Y.K. Zhang, W. Guo, S.Y. Li, X.J. Lu and R.J. Li
Peritrophic membrane proteins are important components of the insect peritrophic membrane. A novel cDNA gene encoding a chitin-binding protein, named secbp66, was identified by immunization screening of the cDNA library of Spodoptera exigua. The full length of secbp66 is 1806 bp, which encodes 602 amino acids. The predicted weight of the protein is 64.2 k.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038789
- DOI:
- 10.4238/gmr.15038789
Upregulation of ICAM-1 and IL-1�² protein expression promotes lung injury in chronic obstructive pulmonary disease
Authors: Y.X. Wang, M.L. Ji, C.Y. Jiang and Z.B. Qian
Chronic obstructive pulmonary disease (COPD) is a devastating lung disorder characterized by sustained airway flow restriction that is not fully reversible. The precise pathogenic mechanisms are unknown, but it is clear that cigarette smoking and chronic inflammatory stimulation are the major causes of COPD. Lung inflammation associated with COPD involves.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037971
- DOI:
- 10.4238/gmr.15037971
Gynophore miRNA analysis at different developmental stages in Arachis duranensis
Authors: Y. Shen, Y.H. Liu, X.J. Zhang, Q. Sha and Z.D. Chen
Peanut is one of the most important oilseed crops in the world that provides a significant amount of lipids and protein for many people. The gynophore plays an important role in gynophore development after fertilization of the peanut ovule. MicroRNAs (miRNAs) play an important role in numerous developmental and physiological p.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048691
- DOI:
- 10.4238/gmr15048691
Investigation of mutations in the SRY, SOX9, and DAX1 genes in sex reversal patients from the Sichuan region of China
Authors: L. Chen, X.P. Ding, X. Wei and L.X. Li
We investigated the molecular genetic mechanism of sex reversal by exploring the relationship between mutations in the sex-determining genes SRY, SOX9, and DAX1 with genetic sex reversal disease. Mutations in the three key genes were detected by polymerase chain reaction (PCR) and sequencing after karyotype analysis. The mutat.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.12.4
- DOI:
- http://dx.doi.org/10.4238/2014.March.12.4
eNOS gene Glu298Asp and 4b/a polymorphisms are associated with renal function parameters in Mexican patients with Fabry disease
Authors: A. Marin-Medina, A.J.L. Brambila-Tapia, V.J. Picos-C�¡rdenas, M.P. Gallegos-Arreola and L.E. Figuera
Fabry disease (FD) is an inherited X-linked lysosomal disease that causes renal failure in a high percentage of affected individuals. The eNOS gene encodes for endothelial nitric oxide synthase, which plays an important role in glomerular hemodynamics. This gene has two main polymorphisms (Glu298Asp and 4b/a) that have been st.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15047802
- DOI:
- 10.4238/gmr15047802
Inhibition of Atg6 and Pi3K59F autophagy genes in neurons decreases lifespan and locomotor ability in Drosophila melanogaster
Authors: P.G. M�Angale and B.E. Staveley
Autophagy is a cellular mechanism implicated in the pathology of Parkinson’s disease. The proteins Atg6 (Beclin 1) and Pi3K59F are involved in autophagosome formation, a key step in the initiation of autophagy. We first used the GMR-Gal4 driver to determine the effect of reducing the expression of the genes encoding thes.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048953
- DOI:
- 10.4238/gmr15048953
Molecular cloning and immune response analysis of putative variable lipoproteins from Mycoplasma mycoides subsp capri
Authors: C.G. Xu, Y.Q. Hao, L. Zhang, R.X. Hao, X.L. Liu and Z.Y. Huang
Mycoplasma mycoides subsp capri is the cause of goat “MAKePS” (Mastitis, Arthritis, Keratoconjunctivitis, Pneumonia, Septicemia) syndrome. We identified three genes (GL_ 000459; 000461; 000462) as variable lipoprotein genes in the M. mycoides subsp capri str. PG3 genome by genomic information and comparative genomi.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.12.5
- DOI:
- http://dx.doi.org/10.4238/2014.March.12.5
Effects of porcine circovirus type 2 and pseudorabies vaccine co-inoculation on regulatory cytokine mRNA expression in pig peripheral blood mononuclear cells
Authors: F. Gao, J.-L. Xie, C.-W. Jia, H.-Y. Ren and S.-H. Zhou
We investigated the immune response effects of porcine circovirus type 2 (PCV2) on cells inoculated with pseudorabies attenuated vaccine (PRV). Real-time PCR was used to detect the mRNA expression levels of the regulatory cytokines IL-4, IL-10, IL-12p40, and IFN-γ in pig peripheral blood mononuclear cells, after in vitro.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.12.6
- DOI:
- http://dx.doi.org/10.4238/2014.March.12.6