Rheumatoid Arthritis
Interleukin-27ΓΆΒ?Β?924A/G gene polymorphism is associated with Rheumatoid Arthritis in Egyptian population
Authors: A. Badawy, A.H. Mohamed, A.A. Enein, R. Qasem, E. Rizk, E. El-Masry , S. Abdellatif and M. Balata
Rheumatoid arthritis (RA) is an autoimmune disease with increasing activity of T lymphocytes and abnormal production of inflammatory cytokines. Interleukin-27 (IL-27), a multifunction cytokine with contradictory inflammatory effect. Polymorphism of IL-27 was reported to be predisposed to many inflammatory diseases and autoimmu.. Read More»
- Genet. Mol. Res. 17(2):
- gmr16039915
- DOI:
- 10.4238/gmr16039915
Association study of polymorphisms between the Radixin gene and rheumatoid arthritis in a Korean population
Authors: H.-K. Kim, J.-S. Joo, H.-Y Lee, J.-T. Kwon, D.-R. Sohn, S.-J. Hong and H.-J. Kim
Radixin (RDX) is part of the ezrin-radixin-moesin (ERM) protein family. It functions as a membrane-cytoskeletal linker in actin-rich cell surface structures and is thought to be essential for cortical cytoskeleton organization, cell motility, adhesion, and proliferation. An increase in phosphorylated ERM in fibroblast-like syn.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.9.14
- DOI:
- http://dx.doi.org/10.4238/2014.May.9.14
NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans
Authors: Q. Zhang, H.W. Fan, J.Z. Zhang, Y.M. Wang and H.J. Xing
Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.17
- DOI:
- 10.4238/2015.October.29.17
Lack of association between rare mutations of the SIAE gene and rheumatoid arthritis in a Han Chinese population
Authors: D.D. Zhang1,2*, F. He3*, H.T. Liu4*, F. Hao1 and J. Zhu5
The function of rare genotypes encoding defective variants of sialic acid acetylesterase (SIAE) in some autoimmune diseases, including rheumatoid arthritis (RA), is ambiguous. We determined whether mutations in the SIAE gene are responsible for RA in a Han Chinese population.DNA was prepared from the venous leukocytes of 444 RA patients and 647 normal con.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.38
- DOI:
- 10.4238/2015.October.29.38
Differential expression of COX-2 in osteoarthritis and rheumatoid arthritis
Authors: H.W. Fan, G.Y. Liu, C.F. Zhao, X.F. Li and X.Y. Yang
In this study, we investigated the differential expression profiles of cyclooxygenase-2 (COX-2) mRNA and proteins in osteoarthritis (OA) and rheumatoid arthritis (RA) patients to elucidate the role of COX-2 expression in the pathogenesis and development of these diseases and to provide novel drug targets for treating arthritis. A total of 60 patients who .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.7
- DOI:
- 10.4238/2015.October.21.7
Meta-analysis demonstrates association between TLR polymorphisms and rheumatoid arthritis
Authors: Y.H. Lee S.-C. Bae G.G. Song
We investigated whether Toll-like receptor (TLR) polymorphisms confer susceptibility to rheumatoid arthritis and whether they influence clinical characteristics of rheumatoid arthritis. Studies were considered relevant for our meta-analysis if at least two comparisons of an issue were available. Eleven studies with 2078 patients with rheumatoid arthritis .. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.7.2
- DOI:
- 10.4238/2013.February.7.2
Lack of association of IL-2RA and IL-2RB polymorphisms with rheumatoid arthritis in a Han Chinese population
Authors: J. Zhu F. He D.D. Zhang J.Y. Yang J. Cheng R. Wu B. Gong X.Q. Liu S. Ma B. Zhou
Polymorphisms in IL-2RA and IL-2RB genes have been reported to confer susceptibility to rheumatoid arthritis (RA) in European populations. We investigated a possilbe association between SNPs in IL-2RA and IL-2RB genes and RA in a Han Chinese population. rs2104286 in IL-2RA and rs743777 in IL-2RB genes were genotyped in a Han Chinese cohort composed of 500 pa.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.27.7
- DOI:
- 10.4238/2013.February.27.7
Identification of significant pathway cross-talk in rheumatoid arthritis by the Monte Carlo cross-validation method
Authors: W. Song, Y.M. Zhang, T. Ma, J. Wang and K.Z. Wang
We attempted to identify significant pathway cross-talk in rheumatoid arthritis (RA) by the Monte Carlo cross-validation (MCCV) method. We therefore obtained and preprocessed the gene expression profile of RA. MCCV involves identifying differentially expressed genes (DEGs), identifying differential pathways (DPs), calculating .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029142
- DOI:
- 10.4238/gmr16029142
Matrix metalloproteinase-3 gene polymorphism and its mRNA expression in rheumatoid arthritis
Authors: M.J. Ma, H.C. Liu, X.Q. Qu, J.L. Wang
Matrix metalloproteinase-3 (MMP-3) can mediate the occurrence and development of rheumatoid arthritis (RA). The MMP3 promoter gene exhibits polymorphism with 5A/6A alleles. We investigated the correlation between the expression of MMP3 gene polymorphism and RA to provide an objective basis for prognosis evaluation. We enrolled.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.17
- DOI:
- 10.4238/2015.December.1.17
Association between peptidyl arginine deiminase 4 (PADI4)-104C/T polymorphism and rheumatoid arthritis: a meta-analysis in the Chinese population
Authors: L.L. Gong, J. Chang and Y.M. Yang
The correlation between the -104C/T polymorphism in the peptidyl arginine deiminase 4 (PADI4) gene and rheumatoid arthritis (RA) risk has been analyzed in several studies. However, the results are inconclusive and remain to be confirmed in several ethnic groups. The effect of the PADI4-104C/T polymorphism on RA risk in the Chinese population was evaluated.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038750
- DOI:
- 10.4238/gmr.15038750