Rheumatoid Arthritis
Decreased MEFV gene expression in rheumatoid arthritis patients
Authors: E.O. Etem, S.S. Koca, D. Erol, S. Yolbas, E. Oz, H. Elyas and A. Is?±k
Rheumatoid arthritis (RA) is a major cause of adult chronic inflammatory arthritis and an autoimmune disease of unknown etiology in which the inflammatory pathology involves T cell activation. Genetic mutations in the Mediterranean fever (MEFV) gene, encoding pyrin, influence the severity of RA, but the underlying mechanisms are not completely understood... Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.3
- DOI:
- 10.4238/2015.February.6.3
Quantitation of glucocorticoid receptor alpha and NF-?ºB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients
Authors: L.O. Cavalcante, M.R. Melo, V.G. Dinis, R.B. Castro, B.D.B. Souza and C.A. Longui
We measured NF-κB, IKK, c-Fos, and GRα mRNA expression and in vivo glucocorticoid sensitivity in patients with rheumatoid arthritis. A very low dose intravenous dexamethasone suppression test and real-time PCR quantitation of mRNA of these genes were performed on blood samples from 21 rheumatoid arthritis patients .. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr970
- DOI:
- 10.4238/vol9-4gmr970
No association of polymorphisms in the suppressor of cytokine signaling (SOCS)-3 with rheumatoid arthritis in the Chinese Han population
Authors: L.P. Sun*, X.L. Ma*, H.X. Liu, Y.S. Wang and X.F. Li
Suppressor of cytokine signaling (SOCS)-3 is a key negative regulator of cytokine signaling that inhibits the JAK/STAT signal transduction pathway; there are reports describing its role in attenuating arthritis through SOCS-3 overexpression. We examined the relationship between polymorphisms in the coding sequence and promoter.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr914
- DOI:
- 10.4238/vol9-3gmr914
The L55M polymorphism of paraoxonase-1 is a risk factor for rheumatoid arthritis
Authors: M. Hashemi, A.K. Moazeni-Roodi, A. Fazaeli, M. Sandoughi, M. Taheri, G.R. Bardestani, Z. Zakeri, D.M. Kordi-Tamandani and S. Ghavami
Paraoxonase-1 (PON1) is a high-density lipoprotein-associated enzyme that exhibits antioxidant and antiatherogenic activities. We examined a possible association between T172A (L55M) and T(-107)C polymorphisms and rheumatoid arthritis. These polymorphisms were determined in 88 rheumatoid arthritis patients and 78 healthy subje.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr893
- DOI:
- 10.4238/vol9-3gmr893
Associations between TNF-?± polymorphisms and susceptibility to rheumatoid arthritis and vitiligo: a meta-analysis
Authors: Y.H. Lee and S.C. Bae
We investigated whether the tumor necrosis factor-a (TNF-α) promoter -238 A/G and -308 A/G polymorphisms are associated with rheumatoid arthritis (RA) and vitiligo susceptibility. MEDLINE and EMBASE databases and a manual search were used to identify articles in which TNF-α polymorphisms were determined in RA or vitiligo patients and controls... Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.6
- DOI:
- 10.4238/2015.May.25.6
CD40 functional gene polymorphisms and mRNA expression in rheumatoid arthritis patients from western Mexico
Authors: I.V. Rom?¡n-Fern?¡ndez, D.F. ?vila-Castillo, S. Cerpa-Cruz,S. Guti?©rrez-Ure?±a, J. Hern?¡ndez-Bello, J.R. Padilla-Guti?©rrez, Y. Valle, M.G. Ram?rez-Due?±as, A.L. Pereira-Su?¡rez and J.F. Mu?±oz-Valle
The CD40 pathway is involved in the development and pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). Two single nucleotide polymorphisms (SNPs) in the CD40 gene, rs1883832 and rs4810485, are associated with susceptibility to inflammatory and autoimmune diseases and are thought to alter CD40 expression .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048775
- DOI:
- 10.4238/gmr15048775
Polymorphisms of the TIM-1 gene are associated with rheumatoid arthritis in the Chinese Hui minority ethnic population
Authors: J.R. Xu, Y. Yang, X.M. Liu, J.Y. Sun and Y.J. Wang
The T-cell immunoglobulin and mucin domain 1 (TIM-1) is known to be associated with susceptibility to rheumatoid arthritis (RA). We investigated the association of four single-nucleotide polymorphisms (SNPs) in the promoter region of the TIM-1 gene with susceptibility to RA in a Chinese Hui ethnic minority group. Using RFLP or.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.9.7
- DOI:
- http://dx.doi.org/10.4238/2012.January.9.7
Association between -174G/C and -572G/C interleukin 6 gene polymorphisms and severe radiographic damage to the hands of Mexican patients with rheumatoid arthritis: a preliminary report
Authors: S.A. Zavaleta-Mu?±iz, L. Gonzalez-Lopez, J.D. Murillo-Vazquez, A.M. Salda?±a-Cruz, M.L. Vazquez-Villegas, B.T. Mart?n-M?¡rquez, J.C. Vasquez-Jimenez, F. Sandoval-Garcia, A.J. Ruiz-Padilla,N.S. Fajardo-Robledo, J.M. Ponce-Guarneros, A.D. Rocha-Mu?±oz, M.F. Alcaraz-Lopez, D. Cardona-M?¼ller, S.E. Totsuka-Sutto,E.D. Rubio-Arellano and J.I. Gamez-Nava
Several interleukin 6 gene (IL6) polymorphisms are implicated in susceptibility to rheumatoid arthritis (RA). It has not yet been established with certainty if these polymorphisms are associated with the severe radiographic damage observed in some RA patients, particularly those with the development of joint bone ankylosis (JB.. Read More»
- Genet. Mol. Res. 15(2):
- gmr15049017
- DOI:
- 10.4238/gmr15049017
Comparative genome-wide gene expression analysis of rheumatoid arthritis and osteoarthritis
Authors: C.Q. Yi, C.H. Ma, Z.P. Xie, Y. Cao, G.Q. Zhang, X.K. Zhou and Z.Q. Liu
Both rheumatoid arthritis (RA) and osteoarthritis (OA) are complex diseases. Studies and treatment of RA and OA have mainly focused on individual factors. However, there is still no clear understanding of their causes and adequate treatment alternatives are still being sought. We applied gene set-enrichment analysis to microarray datasets of RA and OA to .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.3
- DOI:
- 10.4238/2013.March.11.3
Growth factor progranulin blocks tumor necrosis factor-?±-mediated inhibition of osteoblast differentiation
Authors: N. Wang, J. Zhang and J.X. Yang
Tumor necrosis factor-a (TNF-a) stimulates osteoclast differentiation and suppresses osteoblast differentiation, leading to bone loss and decreased bone mass in local inflammation areas in patients with rheumatoid arthritis. The growth factor progranulin (PGRN) is expressed in various types of cells and play crucial roles in t.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038126
- DOI:
- 10.4238/gmr.15038126