Rheumatoid Arthritis
Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran
Authors: M. Hashemi, A.K. Moazeni-Roodi, A. Fazaeli, M. Sandoughi, G.R. Bardestani, D.M. Kordi-Tamandani and S. Ghavami
Decreased paraoxonase-1 (PON1) activity has been associated with rheumatoid arthritis. There are two polymorphisms in serum PON1; one differs in the amino acid at position 192 (Q192R) and the other one differs at position 55 (L55M). We looked for a possible association between Q192R polymorphism and rheumatoid arthritis. The Q.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr728
- DOI:
- 10.4238/vol9-1gmr728
Osteoprotegerin polymorphisms in Chinese Han patients with rheumatoid arthritis
Authors: X.H. Ye, J.L. Chen and R.P. Liu
In order to investigate the association between osteoprotegerin (OPG) gene polymorphisms and rheumatoid arthritis (RA), we studied OPG rs3102735 T/C and rs2073618 G/C polymorphisms in a Chinese Han population comprising 574 patients with RA and 804 controls. Genotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.11
- DOI:
- 10.4238/2015.June.12.11
CTLA-4 and CD86 genetic variants and haplotypes in patients with rheumatoid arthritis in southeastern China
Authors: C.-P. Liu, J.-A. Jiang, T. Wang, X.-M. Liu, L. Gao, R.-R. Zhu, Y. Shen, M. Wu, T. Xu and X.-G. Zhang
The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes are important susceptibility genes associated with autoimmune diseases. CTLA-4 polymorphisms have been found to be associated with various autoimmune diseases. However, the association data are inconsistent for rheumatoid arthritis (RA). We investigated t.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.8
- DOI:
- 10.4238/2013.April.25.8
Association between the PADI4 -94G/A polymorphism and rheumatoid arthritis: a meta-analysis in the Chinese population
Authors: H.X. Chang, B. Zhu, J.H. Yao, J. Wu, J. Wang and W. Sun
Although a number of studies have been conducted on the association between the peptidylarginine deiminase (PADI4) -94G/A polymorphism and rheumatoid arthritis (RA) in the Chinese population, the association remains elusive and controversial. To clarify the impact of the PADI4 -94G/A polymorphism on the risk of RA, a meta-analysis was performed in the Chi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017391
- DOI:
- 10.4238/gmr.15017391
G�±q gene promoter polymorphisms and rheumatoid arthritis in the Han Chinese population are not associated
Authors: Y. Li, Y. Wang, Y. He, D. Wang, L. Deng, Y. Du and G. Shi
Mice that lose Gαq from their immune system can spontaneously develop inflammatory arthritis. Gαq expression in the peripheral blood lymphocytes of rheumatoid arthritis (RA) patients is significantly decreased in comparison to that in healthy individuals, and reduced Gαq expression is closely correlated with RA disease activity. These in.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.January.4.6
- DOI:
- 10.4238/2013.January.4.6
Overexpression of P-glycoprotein on fibroblast-like synoviocytes in refractory rheumatoid arthritis patients: a potential mechanism for multidrug resistance in rheumatoid arthritis treatment
Authors: Y.M. Liu, J.W. Chen, L.X. Chen, X. Xie and N. Mao
This study aims to investigate the role of P-glycoprotein (P-gp) expression level in drug resistance to disease-modifying anti-rheumatic drugs in refractory rheumatoid arthritis (RRA). We evaluated and compared the expression levels of P-gp in fibroblast-like synoviocyte (FLS) cells in patients with rheumatoid arthritis (RA) a.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027927
- DOI:
- 10.4238/gmr.15027927
PKR and HMGB1 expression and function in rheumatoid arthritis
Authors: W.J. Wang, S.J. Yin and R.Q. Rong
The pathogenesis of rheumatoid arthritis (RA) is characterized by inflammation. We aimed to examine the roles of double-stranded RNA-activated protein kinase (PKR) and high-mobility group box chromosomal protein 1 (HMGB1) in a rat model of RA. Male SD rats were divided into three groups: control, RA model, and intervention (RA model plus treatment). The m.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.11
- DOI:
- 10.4238/2015.December.22.11
Effect of sinomenine on the expression of rheumatoid arthritis fibroblast-like synoviocytes MyD88 and TRAF6
Authors: H.C. Zhang, M.X. Liu, E.P. Wang, Z. Lin, G.F. Lv and X. Chen
The effect of sinomenine (SIN) on the toll-like receptor (TLR) signal transduction pathway as well as the expression of myeloid differentiation factor 88 (MyD88) and tumor necrosis factor (TNF) receptor-associated factor-6 (TRAF6) was investigated. SIN inhibition of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) proliferation and RA cartilag.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.41
- DOI:
- 10.4238/2015.December.28.41