Gstt1
Expression analysis of long non-coding RNAs GSTT1-AS1 and IFNG-AS1 and their target genes in lung cancer
Authors: Farbod Esfandi, Zabih Mir Hassani, Shahram Arsang-Jang, Mohammad Taheri, Soudeh Ghafouri-Fard
Long non-coding RNAs (lncRNAs) have recently gained attention because of their regulatory roles on expression of genes involved in the immune response and cancer. In the present study, we evaluated expression of two lncRNAs (GSTT1-AS1 and IFNG-AS1) and their target genes (TNFA and IFNG) in human lung cancer samples and their adjacent non-cancerous tissues.. Read More»
- Genet. Mol. Res. 18(3):
Null polymorphisms in GSTT1 and GSTM1 genes and their associations with smoking and cervical cancer
Authors: Ana L�ºcia Munaro Tacca, Ana Karolina Lopes, Cesar Augusto Sam Tiago Vilanova-Costa, Antonio Marcio Teodoro Cordeiro Silva, Sergio Henrique Nascente Costa, Nathalia Amaral Nogueira, Jessica Enocencio Porto Ramos, Andrea Alves Ribeiro, Vera Aparecida Saddi
Human Papillomavirus (HPV) infection is the main risk factor for cervical cancer. However, other risk factors include smoking and genetic susceptibility. Glutathione-S-Transferases (GST) is enzymes involved in tobacco carcinogens metabolism and genes encoding these enzymes are highly polymorphic. The objective of this study wa.. Read More»
- Genet. Mol. Res. 17(2):
- http://dx.doi.org/gmr16039918
- DOI:
- http://dx.doi.org/10.4238/gmr16039918
Polymorphisms of GSTM1 and GSTT1 genes in symptomatic atherosclerotic patients with hypertension and/or type 2 diabetes mellitus
Authors: R.S. Mascarenhas, F.R.B. Oliveira, J.F. Corr�ªa, K.S.F. e Silva, I.R. Costa, A.M. Barbosa, M.H. Lagares, F.L. Campedelli, M.P. de Morais, J.V.M. Martins, D.A. Rodrigues, e K.K.V.O. Moura
Atherosclerosis is a chronic inflammatory condition and originates due to the accumulation of lipids in the innermost layer of the arteries. It is often related due to other underlying diseases, such as systemic arterial hypertension and type 2 diabetes mellitus, which may be the cause or may contribute to a worse prognosis of.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039836
- DOI:
- 10.4238/gmr16039836
Molecular analysis of the GSTT1 gene polymorphism in patients with clinical manifestation of atherosclerosis
Authors: J.V.M. Martins, D.A. Rodrigues, K.S.F. Silva, I.R. Costa, M.H. Lagares, F.L. Campedelli, A.M. Barbosa, M.P. Morais and K.K.V.O. Moura
Atherosclerosis is a chronic inflammatory disease formed by the accumulation of lipids in the innermost layer and large-caliber artery (tunica intima). This accumulation, along with platelet factors, stimulates the proliferation of muscle cells in this region. Over than 400 genes may be related to the pathology since they regu.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039620
- DOI:
- 10.4238/gmr16039620
Association between primary open angle glaucoma and genetic polymorphisms GSTM1/GSTT1 in patients from Goi�¢nia Central-West Region of Brazil
Authors: C.T.X. Silva, N.B. Costa, K.S.F. Silva, R.E. Silva and K.K.V.O. Moura
In this study, we evaluated the genotype profile of GSTM1 and GSTT1 polymorphisms in patient carriers of primary open-angle glaucoma in the population of Goiânia, GO, Brazil. This case-control study included 100 Brazilian patients with glaucoma and 53 patients without glaucoma. Blood samples were genotyped for polymorphisms in GST genes using polyme.. Read More»
- Genet. Mol. Res. 13(4):
Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility
Authors: A.C.F. Finotti1,2, R.C.P. Costa e Silva1,2, B.M. Bordin1,2, C.T.X. Silva2 and K.K.V.O. Moura1,2
Male infertility is a heterogeneous disorder, with various genetic and environmental factors that contribute to the impairment of spermatogenesis. Genetic causes are responsible for 60% of cases of idiopathic infertility. Polymorphisms of genes that encode detoxifying enzymes of phase II drug metabolism can modify their expression or functi.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr642
- DOI:
- 10.4238/vol8-3gmr642
Role of GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms in the response to chemotherapy and overall survival of advanced non-small cell lung cancer
Authors: W. Jia, J.Y. Sun, K.Y. Jia and X.C. Liu
We evaluated the association between GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms and treatment outcomes of advanced non-small cell lung carcinoma. Between January 2010 and December 2012, a total of 244 patients with non-small cell lung carcinoma were recruited from Yiwu Central Hospital. The GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms we.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037668
- DOI:
- 10.4238/gmr.15037668
Polymorphisms in the GSTT1 and GSTM1 genes are associated with increased risk of preeclampsia in the Mexican mestizo population
Authors: A. Sandoval-Carrillo, M. Aguilar-Duran, F. V�¡zquez-Alaniz,F.X. Castellanos-Ju�¡rez, M. Barraza-Salas, E. Sierra-Campos, A. T�©llez-Valencia O. La Llave-Le�³n and J.M. Salas-Pacheco
Preeclampsia is a pregnancy-specific disorder in humans and a major cause of maternal and neonatal morbidity and mortality. Increasing evidence suggests that oxidative stress plays an important role in the pathogenesis of preeclampsia. The aim of this study was to investigate the relationship between null alleles of the glutat.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.17.3
- DOI:
- http://dx.doi.org/10.4238/2014.January.17.3
Glutathione S-transferase pi polymorphism contributes to the treatment outcomes of advanced non-small cell lung cancer patients in a Chinese population
Authors: J.B. Chen, F. Wang, J.J. Wu and M. Cai
We analyzed the association between polymorphisms in three glutathione S-transferase genes (GSTP1, GSTM1, and GSTT1) and the treatment outcome for advanced non-small cell lung cancer (NSCLC). We recruited 284 NSCLC patients at advanced stage from Department of Radiotherapy in Peace Hospital Attached to Changzhi Medical College between May 2009 and May 201.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037498
- DOI:
- 10.4238/gmr.15037498
Lack of association of genetic polymorphisms of angiotensin-converting enzyme gene I/D and glutathione-S-transferase enzyme T1 and M1 with retinopathy of prematures
Authors: M. Yildiz, M. Karkucak, T. Yakut, O. Gorukmez and A. Ozmen
One of the most frequently observed causes of blindness in infancy is the pathogenesis known as retinopathy of prematurity (ROP). Angiotensin-converting enzyme (ACE) is a vital enzyme in the renin-angiotensin-aldosterone system; it is involved in the development of cardiovascular system diseases linked to I/D polymorphism of t.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr887
- DOI:
- 10.4238/vol9-4gmr887