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Expression analysis of long non-coding RNAs GSTT1-AS1 and IFNG-AS1 and their target genes in lung cancer

Author(s): Farbod Esfandi, Zabih Mir Hassani, Shahram Arsang-Jang, Mohammad Taheri, Soudeh Ghafouri-Fard

Long non-coding RNAs (lncRNAs) have recently gained attention because of their regulatory roles on expression of genes involved in the immune response and cancer. In the present study, we evaluated expression of two lncRNAs (GSTT1-AS1 and IFNG-AS1) and their target genes (TNFA and IFNG) in human lung cancer samples and their adjacent non-cancerous tissues (ANCTs) to find their putative role in the pathogenesis of lung cancer. No significant difference was found in the expression of TNFA, IFNG, GSTT1-AS1 and IFNG-AS1 between tumoral and non-tumoral tissues. Expression levels of these genes were not associated with tumor stage after adjusting the effects of age. Moreover, expression levels of none of these genes were correlated with patients' age. However, significant pairwise correlations were detected between expressions of genes in both tumoral and non-tumoral tissues. TNFA, IFNG, GSTT1-AS1 and IFNG-AS1 are not possibly involved in the pathogenesis of lung cancer.