Glioma
Suppression of the biological activity of neuroglioma cells by down-regulation of miR-1
Authors: Y.Q. Wang, Y. Cai and X.M. Zhong
Neuroglioma is associated with high rates of malignancy, metastasis, and recurrence. Recently, research on the roles of microRNAs (miR) in cancer prognosis has formed an important area of research as differential expression of miRNAs has been observed in different cancers. However, the detailed mechanism by which miRNAs regula.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039256
- DOI:
- 10.4238/gmr16039256
Association of polymorphisms of the xeroderma pigmentosum complementation group F gene with increased glioma risk
Authors: W.K. Zhou, L.Y. Huang, L. Hui, Z.W. Wang, B.Z. Jin, X.L. Zhao, X.Z. Zhang, J.X. Wang, J.C. Wang and R.Z. Wang
We aimed to investigate the role of 4 single nucleotide polymorphisms of the xeroderma pigmentosum complementation group F (XPF) gene (rs3136038, rs1799798, rs1800067, and rs2276466) in glioma, and the roles of gene-gene interactions in the risk of developing this type of cancer. We collected samples from 225 glioma cases and .. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.7
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.7
Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels
Authors: N. Liu1, J. Jiang1, Y.J. Song2, S.G. Zhao3, Z.G. Tong4, H.S. Song1, H. Wu1, J.Y. Zhu1, Y.H. Gu1, Y. Sun1, W. Hua1 and J.P. Qi1
Hypomethylation of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter in glioma cells has been associated with temozolomide resistance. S-adenosylmethionine (SAM), which is produced during folate metabolism, is the main source of methyl groups during DNA methylation... Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.29.10
- DOI:
- 10.4238/2013.October.29.10
Analysis of the gene-protein interaction network in Analysis of the gene-protein interaction network in glioma
Authors: C. Zhou1*, W.J. Teng2*, J. Zhuang1, H.L. Liu3, S.F. Tang1, X.J. Cao4, B.N. Qin4, C.C. Wang4 and C.G. Sun1
Glioma is the most aggressive type of brain tumor. Great progress has been achieved in glioma treatment, but the protein-protein interaction networks underlining glioma are poorly understood. We identified the protein-protein interaction network for glioma based on gene expression and predicted biological pathways underlying the molecular complexes in the.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.3
- DOI:
- 10.4238/2015.November.13.3
Association between the ERCC2 rs13181 polymorphism and the risk of glioma: a meta-analysis
Authors: T.L. Jia, H.J. Wu, H.B. Wang, W.B. Ma and B. Xing
Several studies have focused on the association between the ERCC2 rs13181 polymorphism and glioma risk, but the results were inconclusive. We aimed to conduct a meta-analysis to investigate the role of ERCC2 rs13181 on the risk of glioma. We searched and collated the relevant studies in both Chinese and English through the Pub.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.19.1
- DOI:
- 10.4238/2015.October.19.1
CCDC26 rs4295627 polymorphism (8q24.21) and glioma risk: a meta-analysis
Authors: H.W. Lu, M. Huang, J.H. Wang, X.L. Sun and Y.Q. Ke
The association between the CCDC26 rs4295627 single nucleotide polymorphism (SNP) and the glioma risk has been studied previously, but these studies have yielded conflicting results. The aim of the present study is to analyze this association more vigorously, by means of a meta-analysis. A comprehensive literature search was p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.5.20
- DOI:
- 10.4238/2015.October.5.20
Extract from mistletoe, Viscum album L., reduces Hsp27 and 14-3-3 protein expression and induces apoptosis in C6 rat glioma cells
Authors: E.��. U�§ar N. Arda A. Aitken
Extracts of mistletoe (Viscum album) are intensively used in complementary medicine, but their mechanisms are not fully understood in most cases, and the effects on metabolism have not been investigated in detail. However, some biologically active natural products are well known to provoke unexpected cellular responses. They reduce overexpression of heat .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.24.5
- DOI:
- 10.4238/2012.August.24.5
Genetic polymorphisms of EGF 5'-UTR and NAT2 857G/A associated with glioma in a case control study of Malaysian patients
Authors: K.A. Muthusamy L.H. Lian N. Vairavan K.H. Chua V. Wara
Studies of genetic mutations that have been used in predicting glioma prognosis have revealed a complex relationship between clinical and genetic factors. Epidermal growth factor (EGF) and the NAT2 gene play a central role in carcinogenesis. An adenine (A) to guanine (G) single nucleotide polymorphism at position 61 in the 5'-untranslated region (5'-UTR) of .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.15.7
- DOI:
- 10.4238/2012.June.15.7
Interference on cytoplasmic polyadenylation element-binding proteins affects the invasion ability of glioma stem cells
Authors: H.L. Liu, J.F. Huo, Z.J. Liu and X.B. Chen
Glioma stem cells derived from primary cultures were divided into an experiment group, a control group, and a blank group and subjected to cytoplasmic polyadenilation element-binding protein (CPEBs) interference, transfection with empty vector, and normal culture, respectively, to compare their invasion abilities. Western blotting showed that siRNA-3 had .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.11
- DOI:
- 10.4238/2015.October.28.11
Effects and mechanism of lipoic acid on beta-amyloid-intoxicated C6 glioma cells
Authors: Z.G. Xing, G.D. Yu, L. Qin, F. Jiang and W.H. Zhao
β-amyloid peptides (Aβs) can exert neurotoxic effects through induction of oxidative damage, whereas lipoic acid (LA), a powerful antioxidant, can alleviate oxidative damage. In this study, we explored the effect and mechanism of action of LA on beta-amyloid-intoxicated C6 glioma cells. Cells were randomly divided into three groups: control (veh.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.8
- DOI:
- 10.4238/2015.October.29.8