Glioma
Role of IL-8 gene polymorphisms in glioma development in a Chinese population
Authors: J.W. Fu, K.W. Wang and S.T. Qi
This case-control study aimed to investigate the role of -251 T>A (rs4073) and -781 C>T (rs2227306) polymorphisms in the interleukin-8 (IL-8) gene in the development of glioma in a Chinese population. One hundred and twenty-seven glioma patients and 284 healthy control subjects were recruited to this study between February 2013 and December 2014. Th.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038127
- DOI:
- 10.4238/gmr.15038127
Investigation of the role of XRCC1 genetic polymorphisms in the development of gliomas in a Chinese population
Authors: S.C. Fan, J.G. Zhou and J.Z. Yin
We conducted a study in a Chinese Han population to investigate the role of XRCC1 gene polymorphisms (Arg399Gln and Arg194Trp) with a risk of susceptibility to gliomas. Samples from 115 patients with gliomas and 228 control subjects were consecutively collected between March 2012 and December 2014. Genotype analysis of XRCC1 Arg399Gln and Arg194Trp was pe.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038268
- DOI:
- 10.4238/gmr.15038268
Assessing the association between EFEMP1 rs3791679 polymorphism and risk of glioma in a Chinese Han population
Authors: N. Jiang, Y.P. Peng, X.Y. Wang, C.W. Dou and W.M. He
In this study, we assessed the association between the EFEMP1 rs3791679 polymorphism and glioma risk in a Chinese Han population. A total of 94 glioma patients and 206 healthy controls who conformed to the inclusion and exclusion criteria were recruited from Baogang Hospital between March 2012 and October 2014. The EFEMP1 rs3791679 gene polymorphism was a.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038279
- DOI:
- 10.4238/gmr.15038279
Prognostic value of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms and the susceptibility to gliomas in individuals from Southeast Brazil
Authors: G.R. Pinto, F.K.N. Yoshioka, R.L.L. Silva, C.A. Clara, M.J. Santos, J.R.W. Almeida, R.R. Burbano, J.A. Rey and C. Casartelli
The TP53 tumor suppressor gene codifies a protein responsible for preventing cells with genetic damage from growing and dividing by blocking cell growth or apoptosis pathways. A common single nucleotide polymorphism (SNP) in TP53 codon 72 (Arg72Pro) induces a 15-fold decrease of apoptosis-inducing ability and has been associat.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr415
- DOI:
- 10.4238/vol7-1gmr415
Systematic review on the association between ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms and glioma risk
Authors: C.X. Zhou and J.H. Zhao
Several studies have examined the association between excision repair cross-complementation group 1 (ERCC1) C8092A and ERCC2 Lys751Gln polymorphisms and glioma risk, but the results have been inconclusive. We conducted a meta-analysis of 12 studies to determine the association between ERCC1 rs3212986 and ERCC2 rs13181 genes and glioma susceptibility. We s.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.31.17
- DOI:
- 10.4238/2015.March.31.17
Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro
Authors: P. Coutinho, V. Sandim, J.A. Oliveira, G. Alves and A. Hatagima
The glutathione S-transferases (GSTs), a family of phase II isozymes, detoxify several carcinogens. Genetic variations in GSTs have been associated with increased risk for cancer due to a heritable deficiency in detoxification pathways for environmental carcinogens. Conflicting findings have been reported about the association.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr753
- DOI:
- 10.4238/vol9-1gmr753
IDH1 and IDH2 mutations in different histologic subtypes and WHO grading gliomas in a sample from Northern Brazil
Authors: I.A. Pess�´a, F.E.S. Sagica, N.P. Anselmo, J.R.N. Brito an E.H.C. de Oliveira
Glioma is a term used to describe tumors derived from glial cells. These tumors are divided into subgroups based on the histological morphology and similarity of their differentiated glia cells. Traditionally, they are classified according to the World Health Organization and include astrocytomas, oligodendrogliomas, ependymomas, and oligoastrocytomas. Li.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.6
- DOI:
- 10.4238/2015.June.12.6
ERCC2 rs13181 polymorphism association with glioma susceptibility in a Chinese population
Authors: X. Gao, Y.J. Tang, G.F. Zhang, L. Yu and S.T. Qi
We conducted a case-control study to investigate the role of ERCC2 rs13181 polymorphism in glioma development. A total of 165 patients who were histopathologically diagnosed to have gliomas and 330 controls were collected at Jiujiang First People’s Hospital between July 2012 and June 2014. The ERCC2 rs13181 polymorphism .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027585
- DOI:
- 10.4238/gmr.15027585
Decreased microRNA-198 expression and its prognostic significance in human glioma
Authors: H.B. Man, W.P. Bi and H.H. Man
Previous evidence has shown the association of aberrant miR-198 expression with tumorigenesis and progression of many human malignancies. However, its involvement in human glioma is still unclear. Therefore, the aim of the current study was to investigate the expression and function of miR-198 in human gliomas. Using real-time.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027656
- DOI:
- 10.4238/gmr.15027656
Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy
Authors: M.M. Silva, C.O. Da Fonseca, R. Moura-Neto, J.F. Carvalho, T. Quirico-Santos and M.G. Carvalho
GSTM1 (glutathione S-transferase mu 1) and GSTT1 (glutathione S-transferase theta 1) are critical enzymes for detoxification of endogenous and environmental carcinogens. Constitutive GST gene polymorphisms may be associated with increased risk for cancer development. We made an explorative study of a Brazilian population with malignant glioma to determine.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.2
- DOI:
- 10.4238/2013.May.14.2