Glioma
DNA repair gene XRCC3 variants are associated with susceptibility to glioma in a Chinese population
Authors: J.Y. Huang, J.F. Yang, Q. Qu, J. Qu, F. Liu, F.E. Liu, T. Xiong and S.H. Lu
The susceptibility to glioma is not well understood. It has been suggested that the X-ray cross complementing group 3 (XRCC3) gene influences the capacity to repair DNA damage, leading to increased glioma susceptibility. In this study, we evaluated the relationship between XRCC3 mutations and glioma risk. Genotypes were assessed in 389 Chinese glioma pati.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.18
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.18
Association of three common single nucleotide polymorphisms of SLC7A7 with the development of glioma in a Chinese population
Authors: H. Zhang and W.J. Shi
Gliomas are brain tumors that can be seriously damaging to human health. The SLC7 family is involved in amino acid or peptide transportation. The relationship between SLC7A7 polymorphisms and the development of glioma has been reported previously by a few studies. Therefore, we performed a hospital based case-control study to .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029026
- DOI:
- 10.4238/gmr16029026
Association of p53 Arg72Pro and MDM2 SNP309 polymorphisms with glioma
Authors: J.N. Zhang S.H. Yi X.H. Zhang X.Y. Liu Q. Mao S.Q. Li W.H. Xiong Y.M. Qiu T. Chen J.W. Ge
Epidemiological studies of the association of variants p53 Arg72Pro and MDM2 single-nucleotide polymorphism 309 (SNP309) with glioma risk have produced inconsistent results. The aim of the current study was to evaluate the association of these 2 variants with glioma susceptibility using a meta-analysis approach. For p53 Arg72Pro, 10 case-control studies i.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.4.9
- DOI:
- 10.4238/2012.October.4.9
Correlation between chromosome 1p/19q status and VEGF mRNA expression in gliomas
Authors: B. Yang1*, X.Q. Hao2*, X.W. Zeng3, T.L. Ji3, S. Pan3 and Y.G. Feng1
The chromosome 1p/19q deletion has been reported as a good prognosis marker for gliomas. However, the detection of 1p/19q status alone in glioma patients is not sufficient. The identification of a combination of molecular factors could effectively enhance the prediction accuracy. Thus far, the potential correlation between the 1p/19q status and vascular e.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017322
- DOI:
- 10.4238/gmr.15017322
Mutation analysis of gene PAX6 in human gliomas
Authors: Pinto GR,Clara CA, Santos MJ, Almeida JRW, Burbano RR, Rey JA and Casartelli C
Gliomas are the most common tumors of the central nervous system. In spite of the marked advances in the characterization of the molecular pathogenesis of gliomas, these tumors remain incurable and, in most of the cases, resistant to treatments, due to their molecular heterogeneity. Gene PAX6, which encodes a transcription fac.. Read More»
- Genet. Mol. Res. 6(4):
Mechanism of SEMA3B gene silencing and clinical significance in glioma
Authors: C.H. Pang, W. Du, J. Long and L.J. Song
The aim of the current study was to explore mechanisms of SEMA3B gene expression and its clinical significance in glioma, and provide a theoretical foundation for investigating individualized treatment in glioma. Paraffin-embedded tissues from 43 patients with a confirmed clinical diagnosis of glioma following neurosurgery at the First Affiliated Hospital.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017664
- DOI:
- 10.4238/gmr.15017664
Thermotherapy-induced reduction in glioma invasiveness is mediated by tumor necrosis factor-alpha
Authors: L.J. Qin, T. Zhang, Y.S. Jia, Y.B. Zhang, Y.X. Zhang and H.T. Wang
Thermotherapy has been proven to be effective for the treatment of various tumors, including glioma. We determined whether tumor necrosis factor-alpha (TNF-α) is involved in the regulation of the biological processes of glioma development. Reverse transcription-polymerase chain reaction (RT-PCR) and immunocytochemistry w.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.11
- DOI:
- 10.4238/2015.October.2.11
Investigation of the effects of single-nucleotide polymorphisms in DNA repair genes on the risk of glioma
Authors: K. Gao, S.Q. Mu and Z.X. Wu
Several single-nucleotide polymorphisms (SNPs) in DNA repair gene have been shown to affect DNA repair and to modify susceptibility to cancer. In this study, to investigate the role of these SNPs in glioma, we examined the potential association of 14 SNPs in DNA repair genes with the glioma risk in a Chinese population. We inc.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.27.5
- DOI:
- http://dx.doi.org/10.4238/2014.February.27.5
Association between genetic polymorphisms of PTGS2 and glioma in a Chinese population
Authors: R.P. Lin, C.Y. Yao and D.X. Ren
Several previous studies indicated that genetic polymorphisms in inflammatory factor genes were associated with glioma risk. However, the relationship between the prostaglandin-endoperoxide synthase 2 (PTGS2) genetic polymorphism and glioma remains unclear in the Chinese population. We selected 199 histologically confirmed adult glioma patients and 199 ca.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.25
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.25
Differentiation-inducing effects of betamethasone on human glioma cell line U251
Authors: T. Jin, Y.X. Wang, K. Fan, D.B. Tao, X. Dong and J.S. Shen
We studied the differentiation-inducing effect of betamethasone on human glioma cell line U251 cultured in vitro, and the underlying mechanism. U251 cells were divided into two groups: control group cells, cultured in Dulbecco’s Modified Eagle’s medium containing 10% fetal bovine serum; and medication group cells, treated with 15 μM betamet.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.14.10
- DOI:
- 10.4238/2015.July.14.10