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Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels

Author(s): N. Liu1, J. Jiang1, Y.J. Song2, S.G. Zhao3, Z.G. Tong4, H.S. Song1, H. Wu1, J.Y. Zhu1, Y.H. Gu1, Y. Sun1, W. Hua1 and J.P. Qi1

Hypomethylation of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter in glioma cells has been associated with temozolomide resistance. S-adenosylmethionine (SAM), which is produced during folate metabolism, is the main source of methyl groups during DNA methylation.