Gene
Multidrug resistance gene (MDR1) polymorphisms may not be directly associated with response to imatinib in chronic myeloid leukemia
Authors: J.L. Wang, H.J. Liu, F. Li, W.Y. Yang, J.M. Wang, S.F. Tan and Q. Wang
Our study aimed to investigate the association between multidrug resistance (MDR1) gene polymorphisms and the response to imatinib (IM) in chronic myeloid leukemia (CML). An electronic databases in PubMed, Cochrane Library, Wanfang, China National Knowledge Infrastructure, and VIP were searched using combinations of k.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.4
- DOI:
- 10.4238/2015.November.24.4
Detection limits of the strip test and PCR for genetically modified corn in Brazil
Authors: V.E. Nascimento, ��.V.R. Von Pinho, R.G. Von Pinho and A.D. do Nascimento J�ºnior
Brazilian legislation establishes a labeling limit for products that contain more than 1% material from genetically modified organisms (GMOs). We assessed the sensitivity of the lateral flow strip test in detection of the GMO corn varieties Bt11 and MON810 and the specificity and sensitivity of PCR techniques for their detection. For the strip test, the G.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.27.2
- DOI:
- 10.4238/2012.June.27.2
Targeting exogenous GDNF gene to the bovine somatic cell beta-casein locus for the production of transgenic bovine animals
Authors: X.M. Zhang, F.H. Luo, H.M. Ding, B. Li, J.J. Zhang and Y.J. Wu
Considerable attention is currently being directed toward methods for producing recombinant human proteins in the mammary glands of genetically modified transgenic livestock. However, the expression of inserted genes in transgenic animals is variable and often very low because of the randomness of the site of transgene integra.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.6
- DOI:
- 10.4238/2015.November.24.6
Physical mapping of 18S and 5S rDNA loci and histone H3 gene in grasshopper species of the subfamily Gomphocerinae (Acrididae)
Authors: L.C. Silva-Neto, A.C.S. Bernardino, V. Loreto and R.C. Moura
In this study, fluorescence in situ hybridization (FISH) analysis was used to determine and compare the numbers and chromosomal locations of two multigene families (rDNA and histone H3) in four Neotropical species of gomphocerine grasshoppers. FISH using the 18S rDNA probe identified a single site on the S9 chromosome.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.8
- DOI:
- 10.4238/2015.November.24.8
Expression of the bovine papillomavirus type 1, 2 and 4 L1 genes in the yeast Pichia pastoris
Authors: A.L.S. Jesus, F.C. Mariz, H.M. Souza, M.N. Cordeiro, E.C. Coimbra, M.C.G. Leit�£o, L.M. Nascimento, R.C. Stocco, W. Be�§ak and A.C. Freitas
Papillomaviruses are known to cause benign or malignant lesions in various animals. In cattle, bovine papillomavirus (BPV) is the etiologic agent of papillomatosis and neoplasia of the upper gastrointestinal tract and urinary bladder. Currently, there are no standard diagnostic tests or prophylactic vaccines. Protection against papillomavirus infection is.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.July.19.2
- DOI:
- 10.4238/2012.July.19.2
Genetic structure in fragmented populations of Solanum lycocarpum A. St.-Hil. with distinct anthropogenic histories in a Cerrado region of Brazil
Authors: T.M. Moura, K. Martins, P.S. Sujii, A.M. Sebbenn and L.J. Chaves
Solanum lycocarpum is a woody tree widely distributed in the Cerrado that reaches high population densities in disturbed environments. We examined the genetic diversity and population differentiation of six S. lycocarpum populations with different degrees of human disturbance in order to determine if they are negatively affected by anthropogenic activity... Read More»
- Genet. Mol. Res. 11(3):
- 2012.July.10.16
- DOI:
- 10.4238/2012.July.10.16
Alteration of Phascolosoma esculenta heat shock protein 90 expression under heavy metal exposure and thermal stress
Authors: C.H. Li, X.R. Su, M.Q. Wang, Y.Y. Li, Y. Li, J. Zhou and T.W. Li
The full-length complementary DNA (cDNA) of heat shock protein 90 was cloned from Phascolosoma esculenta (PeHSP90) using expressed sequence tag and rapid amplification of cDNA end approaches. The cDNA of PeHSP90 was 2521 bp including a 5'-untranslated region of 110 bp, a 3'-untranslated region of 230 bp, and an open reading frame of 2181 bp. All of the ch.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.July.10.14
- DOI:
- 10.4238/2012.July.10.14
Effect of exogenous gibberellin on reserve accumulation during the seed filling stage of oilseed rape
Authors: X.Q. Huang, R.Q. He, X.Y. Liao, B. Zhou, W.S. Peng, J.Z. Lin, D.Y. Tang, Y.H. Zhu, X.Y. Zhao and X.M. Liu
Exogenous gibberellins (GAs) are widely applied to increase crop yields, with knowledge about the physiological functioning and biochemistry mechanisms of these phytohormones improving; however, information remains limited about the effect of GAs on seed filling. In this study, the siliques (containing the seeds) of oilseed ra.. Read More»
- Genet. Mol. Res. 13(2):
Genetic diversity and population structure of Chinese pony breeds using microsatellite markers
Authors: L.X. Xu, S.L. Yang, R.Y. Lin, H.B. Yang, A.P. Li and Q.S. Wan
China is one of the principal origins of ponies in the world. We made a comprehensive analysis of genetic diversity and population structure of Chinese ponies based on 174 animals of five indigenous Chinese pony breeds from five provinces using 13 microsatellite markers. One hundred and forty-four alleles were detected; the mean number of effective allele.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.25.4
- DOI:
- 10.4238/2012.June.25.4
Molecular characterization and functional analysis of sheep thyroid transcription factor-1
Authors: L.P. Zhang, B.Y. Ma*, F.X. Han, H.L. Wan, J.P. Wu, L.H. Yu, X.R. Wang and J.Y. Zhu
Thyroid transcription factor-1 (TTF-1), a member of the Nkx2 family of homeodomain-containing proteins, is involved in binding to and in activating the promoters of several important genes in the thyroid, lungs, and brain, and in regulating expression of these tissue-specific genes. We investigated potential roles of sheep (Ovis aries) TTF-1 in regulating.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.18.2
- DOI:
- 10.4238/2012.June.18.2