Gene
Associations between the SRD5A2 gene V89L and TA repeat polymorphisms and breast cancer risk: a meta-analysis
Authors: D. Zhang, Q. Li, H.-C. Qu, T. Yu and Y.-R. Liu
The 5α-reductase type 2 (SRD5A2) gene plays a significant role in the development of breast cancer. The V89L and TA repeat polymorphisms of the SRD5A2 gene have been considered as risk factors for breast cancer. However, the results have been inconsistent. To resolve this conflict, we performed a meta-analysis of studies with V89L (1144 patients and.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.9
- DOI:
- 10.4238/2015.August.7.9
Association between 1p13.3 genomic markers and coronary artery disease: a meta-analysis involving patients and controls
Authors: J. Guo, Y.X. Luo, L.X. Tao1 and X.H. Guo
Recently, genome-wide association studies on cardiovascular disease identified a series of associated single nucleotide polymorphisms in an intergenic region of chromosome 1p13.3. We investigated the association of this locus with cardiovascular disease in 13 case-control studies and undertook a meta-analysis for effect size, heterogeneity, publ.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.18
- DOI:
- 10.4238/2015.August.7.18
PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer
Authors: F.S. Ramos, L.T.R. Serino, C.M.S. Carvalho, R.S. Lima, C.A. Urban, I.J. Cavalli and E.M.S.F. Ribeiro
Changes in the expression of the protein disulfide isomerase genes PDIA3 and PDIA6 may increase endoplasmic reticulum stress, leading to cellular instability and neoplasia. We evaluated the expression of PDIA3 and PDIA6 in invasive ductal carcinomas. Using reverse transcription-quantitative polymerase chain reaction, we compared the mRNA expression level .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.4
- DOI:
- 10.4238/2015.June.26.4
Genome-scale meta-analysis of DNA methylation during progression of lung adenocarcinoma
Authors: Q.H. Zhang, X.H. Dai, Z.M. Dai and Y.N. Cai
Identification of epigenetic alterations in tumors has become a common method for identifying genes critical to cancer development and progression. Thus, we identified DNA methylation alterations on the genome scale during lung adenocarcinoma (LADC) progression to understand the carcinogenic process and identify clinically relevant biomarkers. We found th.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.30
- DOI:
- 10.4238/2015.August.7.30
Analysis of regulatory mechanism after ErbB4 gene mutation based on local modeling methodology
Authors: C.L. Chen and J.W. Zhao
ErbB4 is an oncogene belonging to the epidermal growth factor receptor family and contributes to the occurrence and development of multiple cancers, such as gastric, breast, and colorectal cancers. Therefore, studies of the regulation of ErbB4 in cancerigenic pathway will advance molecular targeted therapy. Advanced bioinforma.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028647
- DOI:
- 10.4238/gmr.15028647
Genetic diversity and taxonomic status of Gymnocypris chilianensis based on the mitochondrial DNA cytochrome b gene
Authors: J.P. Zhang, Z. Liu, B. Zhang, X.Y. Yin, L. Wang, H.N. Shi and Y.J. Kang
In order to study the genetic diversity and taxonomic status of Gymnocypris chilianensis on a molecular level, the mitochondrial DNA cytochrome b gene was sequenced for 74 individuals of G. chilianensis from two locations (Heihe River and Shule River) and 42 individuals of its affinis species Gymnocypris przewalskii. Analyses of genetic diversity and sequ.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.5
- DOI:
- 10.4238/2015.August.10.5
Relationship of the APOA5/A4/C3/A1 gene cluster and APOB gene polymorphisms with dyslipidemia
Authors: H.J. Ou, G. Huang, W. Liu, X.L. Ma, Y. Wei, T. Zhou and Z.M. Pan
We determined the alleles of ten single nucleotide polymorphisms (SNPs) in the APOA5/A4/C3/A1 gene cluster and in APOB in Han Chinese from Xinjiang Shihezi, China using MALDI-TOF mass spectrometry, and explored the correlation between these SNPs and dyslipidemia through a case-control study design with 250 patients and 250 normal controls. All S.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.8
- DOI:
- 10.4238/2015.August.10.8
Effects of conjugated linoleic acid on the expression levels of miR-27 and miR-143 inpig adipose tissue
Authors: R.L. Qi, Y. Chen, J.X. Huang andF.Y. Yang
In this study, we evaluated the effect and possible mechanism of action of dietary conjugated linoleic acid (CLA) on pig body fat deposition. Landrace piglets (N = 48) were randomly divided into three groups, which were fed diets containing 0% (control), 1%, or 2% CLA. Dorsal and abdominal subcutaneous adipose tissues were collected, and real-time polymer.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.7
- DOI:
- 10.4238/2015.June.26.7
Expression profile of tumor suppressor gene RASSF1 in lacrimal gland carcinoma
Authors: C.H. Zeng, B. Guo, J. Chen, W.M. He and Q.L. Luo
We examined the expression pattern of the tumor suppressor gene RAS association domain family gene 1 (RASSF1) in lacrimal gland carcinoma and analyzed its relationship with the oncogenesis and progression of tumors. Sixty-two patients (30 males, 32 females, average age = 47 ± 3.5 years) admitted with lacrimal gland carcinoma to the Department of Op.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.8
- DOI:
- 10.4238/2015.June.26.8
Identification of robust adaptation gene regulatory network parameters using an improved particle swarm optimization algorithm
Authors: X.N. Huang and H.P. Ren
Robust adaptation is a critical ability of gene regulatory network (GRN) to survive in a fluctuating environment, which represents the system responding to an input stimulus rapidly and then returning to its pre-stimulus steady state timely. In this paper, the GRN is modeled using the Michaelis-Menten rate equations, which are.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028652
- DOI:
- 10.4238/gmr.15028652