Gene
Tetradecyl 2,3-dihydroxybenzoate promotes functional recovery after spinal cord injury in adult rats
Authors: Y.M. Ding, J.Y. Zhu, S.J. Zhang, S.S. Zhang, C. Wang, L.L. Wang and X. Zhang
Tetradecyl 2,3-dihydroxybenzoate (ABG001) is a small molecule separated from gentian extract that has a similar effect to nerve growth factor. It is not clear whether it can promote functional recovery in animals suffering from a central nervous system injury. In order to explore the role of ABG001 in restoration of tissue str.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028653
- DOI:
- 10.4238/gmr.15028653
Significance of Bcl10 gene mutations in the clinical diagnosis of MALT-type ocular adnexal lymphoma in the Chinese population
Authors: J. Zhu, R.L. Wei, Y.L. Pi and Q. Guo
We investigated the expression of Bcl10 gene mutations in mucosa-associated lymphoid tissue-type ocular adnexal lymphoma (OAL), atypical lymphoid hyperplasia (ALH), and reactive lymphoid hyperplasia (RLH) in the Chinese population and its role in clinical diagnosis and pathogenesis. Forty-three samples were collected during patient surgeries. Pathological.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.12.6
- DOI:
- 10.4238/2013.April.12.6
Mutational analyses of the TSC1 and TSC2 genes in cases of tuberous sclerosis complex in Chinese Han children
Authors: G.-X. Wang, D.-W. Wang, C.-Y. Yi, J.-S. Qu and Y.-L. Wang
Tuberous sclerosis complex (TSC) is an autosomal dominant neurogenetic disorder characterized by hamartomas in multiple organs and is caused by a wide spectrum of mutations in 1 of 2 causative genes (TSC1 or TSC2). Here, we present mutational analyses of the TSC1 and TSC2 genes in 4 cases of TSC in Chinese Han children, including 2 familial and 2 sporadic.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.12.3
- DOI:
- 10.4238/2013.April.12.3
Genetic diversity analysis of Capsicum spp germplasm bank accessions based on �±/�²-esterase polymorphism
Authors: E.R. Monteiro, A.R. Bronzato, G.R. Orasmo, A.C.A. Lopes, R.L.F. Gomes, C.A. Mangolin and M.F.P.S. Machado
Genetic diversity and structure were analyzed in 10 accessions belonging to Banco Ativo de Germoplasma de Capsicum located at Federal University of Piauí in northwestern Brazil that receives pepper samples grown in community gardens in various regions and Brazilian states. Selections were made from seeds of C. chinense (4 accessions), C. annuum (5 .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.12.2
- DOI:
- 10.4238/2013.April.12.2
Phylogenetic relationships of twenty Gymnothorax species based on cytochrome b sequence data
Authors: M. Du, S.W. Yin and B.Z. Niu
To study the phylogenetic relationships of the genus Gymnothorax (moray eels) distributed in South China Sea, polymerase chain reactions were performed, and the amplification products were sequenced by cloning into the PMD18T-vector (TaKaRa). The entire gene sequences encoding cytochrome b (1140 bp) for 16 Gymnothorax (G. flav.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028157
- DOI:
- 10.4238/gmr.15028157
Construction of a gene-gene interaction network with a combined score across multiple approaches
Authors: A.M. Zhang, H. Song, Y.H. Shen and Y. Liu
Recent progress in computational methods for investigating physical and functional gene interactions has provided new insights into the complexity of biological processes. An essential part of these methods is presented visually in the form of gene interaction networks that can be valuable in exploring the mechanisms of disease. Here, a combined network b.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.11
- DOI:
- 10.4238/2015.June.26.11
S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer
Authors: Z. Hussain, M.I. Khan, M. Shahid and F.N. Almajhdi
DNA methylation is a fundamental epigenetic mechanism in regulating the expression of genes controlling crucial cell functions in cancer development. Gene silencing via CpG island methylation/demethylation in the promoter region is one of the mechanisms by which different genes are inactivated/activated in human cancers. Tissue inhibitor of metalloprotein.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.10.6
- DOI:
- 10.4238/2013.April.10.6
Analysis of uridine diphosphate glucuronosyl transferase 1A1 gene mutations in neonates with unconjugated hyperbilirubinemia
Authors: X.H. Guo, Y.F. Sun, M. Cui1, J.B. Wang, S.Z. Han and J. Miao
This study was carried out to analyze uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) gene mutations in neonates with unconjugated hyperbilirubinemia, from two different ethnic groups. Polymerase chain reaction and gene sequencing were used to analyze the differences in genotypes and allele frequencies of differ.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028373
- DOI:
- 10.4238/gmr.15028373
Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population
Authors: F.M. Feng, X.X. Liu, Y.H. Sun, P. Zhang, S.F. Sun, B. Zhang, X.T. Wang and L.J. Lu
We investigated the association between interleukin (IL)-6 and IL-10 gene polymorphisms and the susceptibility to pulmonary tuberculosis (PTB). DNA samples were obtained from 191 Han Chinese patients with PTB and 191 healthy control subjects. IL-6 (-572, -174, -597) and IL-10 (-1082, -819) polymorphisms were analyzed using pol.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.14
- DOI:
- 10.4238/2014.September.26.14
Regulating effects of insertion direction of matrix attachment regions on transgenic expression in stably transformed Chinese hamster ovary cells
Authors: F. Wang, J.H. Zhang, T.Y. Wang, W.H. Dong, X.J. Yang, X.Y. Wang,L. Wang, R. Yang, Q. Li and C.P. Zhao
We investigated the effects of different directions of insertion of matrix attachment region (MAR) sequences on transgenic expression in stably transformed Chinese hamster ovary (CHO) cells. The MAR sequences were inserted in forward or reverse directions into the expression vectors, and transfected into CHO cells. The expression of the chloramphenicol ac.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.12
- DOI:
- 10.4238/2015.June.26.12