Cervical Cancer
Null polymorphisms in GSTT1 and GSTM1 genes and their associations with smoking and cervical cancer
Authors: Ana L�ºcia Munaro Tacca, Ana Karolina Lopes, Cesar Augusto Sam Tiago Vilanova-Costa, Antonio Marcio Teodoro Cordeiro Silva, Sergio Henrique Nascente Costa, Nathalia Amaral Nogueira, Jessica Enocencio Porto Ramos, Andrea Alves Ribeiro, Vera Aparecida Saddi
Human Papillomavirus (HPV) infection is the main risk factor for cervical cancer. However, other risk factors include smoking and genetic susceptibility. Glutathione-S-Transferases (GST) is enzymes involved in tobacco carcinogens metabolism and genes encoding these enzymes are highly polymorphic. The objective of this study wa.. Read More»
- Genet. Mol. Res. 17(2):
- http://dx.doi.org/gmr16039918
- DOI:
- http://dx.doi.org/10.4238/gmr16039918
Role of IL17A rs2275913 and rs3748067 polymorphisms in the risk cervical cancer
Authors: A.Q. Niu, Y.H. Cao, H. Wang, X. Zhang, B. Zhu and Z.H. Li
Cervical cancer is a serious public health problem and is associated with high cancer-related mortality in females worldwide. The expression of IL17A can increase the migration and invasiveness of cervical cancer cells by activating the NF-κB signal pathway. Single-nucleotide polymorphisms (SNPs) can alter gene function .. Read More»
- Genet. Mol. Res. 16(3):
- gmr16038826
- DOI:
- 10.4238/gmr16038826
Synergic effect of oral contraceptives, GSTP1 polymorphisms, and high-risk HPV infection in development of cervical lesions
Authors: B.S. Chagas, A.P.A.D. Gurgel, S.S.L. Paiva J�ºnior, R.C.P. Lima,M.N. Cordeiro, R.R. Moura, A.V.C. Coelho, K.C.G. Nascimento,J.C. Silva Neto, S. Crovella and A.C. Freitas
Human papillomavirus (HPV) infection is considered a risk factor for cervical cancer. Even if the high-risk HPV (HR-HPV) infection is necessary, environmental co-factors and genetic susceptibility also play an important role in cervical cancer development. In this study, a possible association of rs1695 GSTP1 polymorphisms, HR.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039742
- DOI:
- 10.4238/gmr16039742
Preset ureter catheter in laparoscopic radical hysterectomy of cervical cancer
Authors: L. Han, R. Cao, J.Y. Jiang, Y. Xi, X.C. Li and G.H. Yu
The aim of this study was to evaluate the clinical efficacy of a temporary ureteral catheter in preventing iatrogenic ureteral damage in cervical cancer patients undergoing laparoscopic radical hysterectomy. All cases had confirmed diagnoses of cervical cancer preoperatively between December 2008 and December 2012 in our hospi.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.9.6
- DOI:
- http://dx.doi.org/10.4238/2014.May.9.6
Comparison of the prevalence and distribution of human papillomavirus infection and cervical lesions between urban and native habitants of an Amazonian region of Peru
Authors: M. Martorell, J.A. Garcia-Garcia, D. Gomez-Cabrero, A. del Aguila
We made a study of the prevalence of human papillomavirus (HPV) and cervix lesions in an Amazonian Bora native population (Bn) and compared it with the prevalence in an urban population in Iquitos (Iq). We also examined the distribution of HPV types among abnormal cervical smears in the Iq population. Swabs and cytologies were collected from 472 females. .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.6.14
- DOI:
- 10.4238/2012.August.6.14
Effect of progranulin (PGRN) on the proliferation and senescence of cervical cancer cells
Authors: X.Y. Zhang1, Z.X. Pan1, H. Liu1, J.L. Yu1, G.X. Li2, H.Y. Wang3 and M.M. Liu4
We investigated the effect of progranulin (PGRN) expression on the proliferation and senescence of cervical cancer cells. PGRN small interfering RNA (siRNA) was introduced into the SiHa and HeLa cell lines of human cervical carcinoma using liposome-mediated transfection. The expression levels of PGRN in each cell line after transfection of PGRN siRNA were.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.18
- DOI:
- 10.4238/2015.November.13.18
Association analysis of IL-17A and IL-17F polymorphisms in Chinese women with cervical cancer
Authors: L. Li, Y.L. Tian, X.M. Lv, H.F. Yu, Y.Y. Xie, J.D. Wang and W. Shi
We selected six tagged single nucleotide polymorphisms (SNPs) in the interleukin 17A (IL-17A) and IL-17F genes, and evaluated the relationship between the six common SNPs and environmental factors in cervical cancer patients. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the IL-17A (rs22.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.6
- DOI:
- 10.4238/2015.October.9.6
Effects of miRNA-143 and the non-coding RNA MALAT1 on the pathogenesis and metastasis of HeLa cells
Authors: L. Zhang, H.E.X.D. Niyazi, H.R. Zhao, X.P. Cao, M.N.S. Abudula, W.J. Ye, S.A. Zhang, R.H.M. Yiming, Y. Zhang, W.P. Su, R. Chen, Y. Ouyang, N. Miao and Y.X. Bao
Cervical cancer is a common female malignancy of global dimensions. MicroRNAs (miRNAs) play crucial roles in the development, differentiation, proliferation, and apoptosis of tumors. The non-coding RNA MALAT1 participates in various physiological processes that are important for proper functioning of the body. Here, we analyze.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019269
- DOI:
- 10.4238/gmr16019269
Association analysis of rs2275913G>A and rs763780T>C interleukin 17 polymorphisms in Chinese women with cervical cancer
Authors: L.X. Sun, X.B. Wang and X.J. Huang
We conducted a case-control study with a relatively large sample size, and investigated the association between rs2275913G>A and rs763780T>C and the risk of cervical cancer. Three hundred and six newly diagnosed patients with histologically confirmed cervical cancer and 354 cancer-free control subjects were recruited from the Forestry General Hospit.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.22
- DOI:
- 10.4238/2015.October.28.22
5-Aza-2�-deoxycytidine may influence the proliferation and apoptosis of cervical cancer cells via demethylation in a dose- and time-dependent manner
Authors: T.T. Yao S.M. Mo L.Y. Liu H.W. Lu M.L. Huang Z.Q. Lin
The methylation of tumor suppressor genes has been shown to be involved in many human cancers. 5-Aza-2’-deoxycytidine (5-Aza-CdR) can reactivate the expression of methylated tumor suppressor genes. In our study, 2 human cervical cancer cell lines, HeLa and SiHa, were treated with different concentrations (20, 10, 5, and 2.5 μM) of 5-Aza-CdR for 2.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.4.5
- DOI:
- 10.4238/2013.February.4.5