Cervical Cancer
Expression levels of survivin, Bcl-2, and KAI1 proteins in cervical cancer and their correlation with metastasis
Authors: X.L. Zhou and M. Wang
Cervical cancer is associated with abnormal expression of multiple genes. Survivin and Bcl-2 proteins are apoptosis inhibitors. The tumor suppressor gene CD82, which encodes the protein KAI1, is downregulated in cervical cancer, and is associated with differentiation degree. We investigated the expression levels of three proteins and their correlation wit.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.6
- DOI:
- 10.4238/2015.December.16.6
Analysis of HLA-DQB1 allele polymorphisms in Uyghur women with cervical cancer
Authors: L. Han, S. Husaiyin, L. Wang, K.D. Wusainahong, X. Fu and M. Niyazi
In Uyghur women, mortality rates from cervical cancer are amongst the highest in the nation, and genetic susceptibility probably plays a role in the pathogenesis of the disease. We investigated the correlation between polymorphisms of the HLA-DQB1 allele and cervical cancer in Xinjiang Uyghur women. Cervix tissue samples from 80 cases of cervical cancer a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.25
- DOI:
- 10.4238/2015.December.16.25
Molecular analysis and conventional cytology: association between HPV and bacterial vaginosis in the cervical abnormalities of a Brazilian population
Authors: A.L. Peres, J.R.S.L. Camarotti, M. Cartaxo, N. Alencar, R.C. Stocco, W. Be�§ak, N.T. Pontes-Filho, R.F.F. Ara�ºjo, J.L. Lima-Filho and D.B.G. Martins2
We investigated the association between bacterial vaginosis (BV) and human papillomavirus (HPV) infection in Papanicolaou smears in a Brazilian population. Cross-sectional analysis was performed on 673 samples collected from women attending public health centers in Olinda (PE, Brazil) by conventionalcytology methodology and molecular analysis, PCR tests (.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.13
- DOI:
- 10.4238/2015.August.14.13
Prevalence of human papillomavirus (HPV) type 16 variants and rare HPV types in the central Amazon region
Authors: M.M. Castro, I.P. Farias, C.M. Borborema-Santos, G. Correia and S. Astolfi-Filho
Infection by human papillomavirus (HPV) is one of the primary causes of mortality by cancer in northern Brazil. Sexually active women from Manaus, Amazonas, without cytological alterations and women with pre-malignant and malignant cytological alterations were examined for HPV virus, identified via PCR and sequencing. The targ.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr992
- DOI:
- 10.4238/vol10-1gmr992
Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer
Authors: P. Liu, F. Xin and C.F. Ma
Previous studies have reported that miR-196a is upregulated in cervical cancer tissues and cell lines. However, whether serum miR-196a is increased in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), and its potential clinical value remained unknown. In total, 105 cervical cancer patients, 86 CIN patients, and 50 healthy voluntee.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.25
- DOI:
- 10.4238/2015.December.22.25
Evaluation of novel assays for the detection of human papilloma virus in self-collected samples for cervical cancer screening
Authors: Q. Chen, H. Du, R. Zhang, J.H. Zhao, Q.C. Hu, C. Wang, G.X. Wang, J.L. Tang and R.F. Wu
The aim of this study was to evaluate the performance of three new high-risk human papillomavirus (HPV) assays for primary cervical cancer screening, by using self-collected samples, and to identify an HPV assay that could overcome the major obstacles faced during large-scale population-based screening. Two hundred and ten wom.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027896
- DOI:
- 10.4238/gmr.15027896
Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer
Authors: J.P. Kleine, C.M. Camargo-Kosugi, C.V. Carvalho, F.C. Silva and I.D.C.G. Silva
The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer. Genotypes of 222 women were an.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.3
- DOI:
- 10.4238/2015.December.29.3