Cervical Cancer
Association between IL-10 genetic variations and cervical cancer susceptibility in a Chinese population
Authors: C.Y. Bai, X.Y. Shi, J. He, J. Xue and Y. Feng
We conducted an investigation into the role of the IL-10 polymorphisms -592A/C (rs1800872), -819C/T (rs1800871), and -1082A/G (rs1800896) in cervical cancer risk in a Chinese population. A case-control study was carried out, including 165 newly diagnosed cervical cancer patients and 165 control subjects. The polymerase chain reaction-restriction fragment .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038116
- DOI:
- 10.4238/gmr.15038116
Human papillomavirus infection in Brazilian women with normal cervical cytology
Authors: P.M. Miranda, B.C.V. Pitol, M.S. Moran, N.N.T. Silva, P.M. Felix, J.L. Lima-Filho, C.M. Carneiro, I.D.C.G. Silva, R.F. Carvalho, A.A. Lima, W. Be�§ak and R.C. Stocco
We examined the prevalence of human papillomavirus (HPV) infection in a sample of Brazilian women presenting normal cervical cytology. Possible interactions between patient characteristics and HPV infection were analyzed in order to provide background data to improve cervical cancer screening and prophylaxis. Cervical samples .. Read More»
- Genet. Mol. Res. 11(2):
- http://dx.doi.org/2012.June.29.8
- DOI:
- http://dx.doi.org/10.4238/2012.June.29.8
HPV genotype analysis for women in Shaanxi Province of China
Authors: J. Li, Y.Y. Wang, X.F. Tian, X. Nan, T. Yan, P. Wang, Y.L. Fu and G.Q. Wang
The aim of this study was to examine the subtype distribution of human papilloma virus (HPV) in women in the Shaanxi Province of China. A DNA chip, along with polymerase chain reaction amplification and reverse dot blot technology, was adopted to analyze the HPV genotypes of 22,937 cases of cervical cell specimens. The HPV inf.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15047178
- DOI:
- 10.4238/gmr15047178
microRNA 421 induces apoptosis of c-33a cervical cancer cells via down-regulation of Bcl-xL
Authors: X.J. Lai, X.Y. Cheng and L.D. Hu
Cervical cancer is a life-threatening condition. MicroRNAs (miRNAs) can promote or inhibit cell death and proliferation. The present study investigated the effect of miRNA 421 on the growth and apoptosis of cervical cancer cells. miRNA 421 and control miRNA were synthesized and transfected into c-33a cervical cancer cells. A t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048853
- DOI:
- 10.4238/gmr15048853
Frequency of human papillomavirus types 16, 18, 31, and 33 and sites of cervical lesions in gynecological patients from Recife, Brazil
Authors: M.F.P.T. Baldez da Silva, V. Guimar�£es, M.A.R. Silva, C.M. Medeiros do Amaral, W. Be�§ak, R.C. Stocco, A.C. Freitas and S. Crovella
Human papilloma virus (HPV) is a well-established cause of cervical cancer. While many studies have been performed so far on HPV viral biology, mode of infection and prevention measures, scanty information is available on lesion sites of infected women and the incidence of viral types at specific locations. We looked for a pos.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.1.3
- DOI:
- 10.4238/2012.March.1.3
BORIS and CTCF are overexpressed in squamous intraepithelial lesions and cervical cancer
Authors: N. VelÃ?¡zquez-HernÃ?¡ndez, M.A. Reyes-Romero, M. BarragÃ?¡n-HernÃ?¡ndez, F. Guerrero-Romero, M. RodrÃ?Âguez-Moran, M. Aguilar-DurÃ?¡n and B. Lazalde Medina
We investigated the expression of Brother of Regulator of Imprinted Sites (BORIS) and CCCTC-binding factor (CTCF) in squamous intraepithelial lesions and cervical cancer. To analyze BORIS and CTCF expression, an endocervical cytobrush sample was taken for total RNA isolation. CTCF and BORIS mRNA was quantified from total RNA using quantitative reverse tra.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.8.7
- DOI:
- 10.4238/2015.June.8.7
Association of the programmed cell death-1 PD1.5 C>T polymorphism with cervical cancer risk in a Chinese population
Authors: X.F. Li, X.Q. Jiang, J.W. Zhang and Y.J. Jia
The association of the programmed cell death-1 PD1.5 C>T polymorphism with cervical cancer risk has not been investigated. In this hospital-based case-control study, we analyzed 256 patients with cervical cancer and 250 healthy controls. Pearson chi-square test was used to examine differences in the distribution of genotype.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016357
- DOI:
- 10.4238/gmr.15016357
Clinical value of concurrent radiochemotherapy in cervical cancer and comparison of ultrasonography findings before and after radiochemotherapy
Authors: W.M. Yan,X.Z. Li,Z.L. Yu,J. Zhang and X.G. Sun
Herein, we investigated the clinical value of concurrent radiochemotherapy for patients with advanced cervical cancer and its effects on adverse clinical symptoms. Forty patients with cervical cancer were recruited from January 2011 to January 2014 for this study. Participants were randomly allocated into a test or control group, with 20 patients in each .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.13
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.13
FOXO1 is a tumor suppressor in cervical cancer
Authors: B. Zhang, L.S. Gui, X.L. Zhao, L.L. Zhu and Q.W. Li
Forkhead box protein O1 (FOXO1) is an important transcriptional regulator of cell proliferation, and is considered essential for tumor growth and progression. However, the function of FOXO1 in human cervical cancer remains unclear. In this study, we investigated the role of FOXO1 in cervical cancer. Our results showed that FOXO1 expression was lower in ce.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.3
- DOI:
- 10.4238/2015.June.18.3
Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin
Authors: W.M. Lin and Z.G. Li
Development of chemoresistance is a major obstacle that leads to the recurrence and progression of cervical cancer (CC). Autophagy, meaning, “eating of self”, has shown paradoxical functions in tumors. In this study, we first investigated the process of autophagy induction by cisplatin in CC cells. Next, we investigated the role of autophagy i.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.18
- DOI:
- 10.4238/2015.December.14.18