Analysis of the beta-globin gene in DNA of suspected thalassemic great apes
Authors: J. Vuch, M.S. Siori, M.P. Bigatti, L. Segat, G. De Fabrizio and S. Crovella
DNA was recovered from teeth of 2 great ape skeletons, Pan troglodytes (Ptr) and Pongo pygmaeus (Ppy), belonging to a 19th-century zoological collection. The skeletons presented morphological alterations possibly associated with β-thalassemia: Ptr had deformation of the calvaria and oro-maxillo-facial bones with porotic hyperostosis and extend.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.21.4
- DOI:
- 10.4238/2013.May.21.4
Expression of IL-21 in rats with inflammatory bowel disease
Authors: J.N. Mao, Y.S. Shen, X.Y. Luo and Y.L. Zhi
The purpose of this study was to investigate the expression of interleukin (IL)-21 in rats with inflammatory bowel disease (IBD). Fifty adult Wistar rats were randomly divided into two groups: DSS, in which IBD was induced by giving the rats 7% DSS for seven days in their water, and a water control. Blood samples were collected and the concentration of IL.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.33
- DOI:
- 10.4238/2015.December.16.33
Association between IL-1RN gene polymorphisms and susceptibility to ankylosing spondylitis: a large Human Genome Epidemiology review and meta-analysis
Authors: G.X. Jin, J.Z. Duan, W.L. Guo, L. Li, S.Q. Cui and H. Wang
We made a Human Genome Epidemiology review and meta-analysis to examine a possible association between interleukin-1 receptor antagonist (IL-1RN) polymorphisms and susceptibility to ankylosing spondylitis (AS). Studies of IL-1RN polymorphisms and susceptibility to AS were found by searching the Pubmed, Cochrane library, Embase, Web of Science, Springerlin.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.21.3
- DOI:
- 10.4238/2013.May.21.3
Expressed sequence tag-simple sequence repeat-based molecular variance in two Salicornia (Amaranthaceae) populations
Authors: Z.L. Xu, Z. Ali, J.X. Yi, X.L. He, D.Y. Zhang, G.H. Yu, A.A. Khan, I.A. Khan and H.X. Ma
Salicornia spp is one of the most salt-tolerant vascular plants and is native to salt marshes and estuaries. We developed expressed sequence tag derived-simple sequence repeat (EST-SSR) markers for estimating genetic diversity and marker-assisted Salicornia breeding. Six polymorphic EST-SSRs of 40 detected 27 alleles, ranging .. Read More»
- Genet. Mol. Res. 10(2):
Bicluster and regulatory network analysis of differentially expressed genes in adenocarcinoma and squamous cell carcinoma
Authors: L. Li, J. Zhu, S.-X. Guo and Y. Deng
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the major histological types of non-small cell lung cancer (NSCLC). Although differences in molecular, histological, and clinical characteristics have been reported for both subtypes, no specific therapy exists thus far. The aim of this analysis was to identify potential therapeutic target genes th.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.21.2
- DOI:
- 10.4238/2013.May.21.2
A single nucleotide polymorphism in GABAA receptor isoforms is potentially responsible for isoflurane sensitivity in mice
Authors: X. Wang, Z.G. Song, D.X. Huang, H. Gao, Q. Wang and Z.P. Wang
GABAA receptors are chloride channels in the brain that are activated by binding with g-aminobutyric acid (GABA). The cDNA sequences of GABAA receptor subunits from two strains of mice with different sensitivities to isoflurane were compared to identify nucleotide mutations. Included 80 mice from two strains with different sen.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027340
- DOI:
- 10.4238/gmr.15027340
Genetic diversity of rhg1 and Rhg4 loci in wild soybeans resistant to soybean cyst nematode race 3
Authors: C.P. Yuan, Y.J. Wang, H.K. Zhao, L. Zhang, Y.M. Wang, X.D. Liu, X.F. Zhong and Y.S. Dong
Over-utilization of germplasms that are resistant to the soybean cyst nematode (SCN) in soybean breeding programs can lead to genetic vulnerability in resistant cultivars. Resistant wild soybean (Glycine soja) is considered an invaluable gene source for increasing the genetic diversity of SCN resistance. In this study, we geno.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027386
- DOI:
- 10.4238/gmr.15027386
A novel and efficient strategy for practical identification of tomato (Solanum lycopersicon) varieties using modified RAPD fingerprints
Authors: N.K. Korir, X.Y. Li, X.P. Leng, Z. Wu, C. Wang and J.G. Fang
Tomato breeding and variety development have led to the generation of a large number of varieties in many countries worldwide. This has created a growing and urgent need for an improved strategy for genotyping and identification since the traditional methods based on phenotype are growing unreliable. DNA markers could provide distinct benefits in tomato v.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.11.2
- DOI:
- 10.4238/2013.June.11.2
Association between the XPG gene Asp1104His polymorphism and lung cancer risk
Authors: B. Zhou, X.M. Hu and G.Y. Wu
It has been suggested that the xeroderma pigmentosum complementation group G (XPG) gene Asp1104His polymorphism is linked to susceptibility to lung cancer. However, the results from the published studies are contradictory rather than conclusive. With this meta-analysis, we aimed to achieve a better understanding of the effects.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027395
- DOI:
- 10.4238/gmr.15027395
In silico characterization of putative members of the coffee (Coffea arabica) ethylene signaling pathway
Authors: A.A. Lima, S.A. S�¡gio, A. Chalfun-J�ºnior and L.V. Paiva
The plant hormone ethylene is involved in several developmental and physiological processes in plants, including senescence, fruit ripening and organ abscission, as well as in biotic and abiotic stress responses. Initiation of these processes involves complex regulation of both ethylene biosynthesis and the ability of cells to.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1314
- DOI:
- 10.4238/vol10-2gmr1314