Ability of HMGB1 protein to bind to intrinsically bent and non-bent DNA sites in the AMPD2 gene amplicon
Authors: K.J.R. Passos, A. Fiorini, F.R. Rosado, D.V.B. Freitas, Q.A. Lima Neto, J.R. Pattaro Junior, V.P. Gaspar and M.A. Fernandez
HMGB-like proteins are architectural chromatin factors, and their function is heavily dependent on their ability to interact with DNA (especially non-canonical DNA structures). HMGB1 is involved in many DNA processes, and dysregulation of HMGB protein expression has profound effects on cellular transcription, resulting in seve.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027441
- DOI:
- 10.4238/gmr.15027441
Influence of the XbaI polymorphism in the estrogen receptor-�± gene on human spermatogenic defects
Authors: J. Meng, X. Mu and Y.M. Wang
Polymorphisms of estrogen receptor (ER) genes have been implicated in male infertility, but studies of this association have produced conflicting results. The present study was conducted to examine whether polymorphisms within the ERα and ERβ genes are susceptibility factors for human male idiopathic infertility in Chinese men. We investigated .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.11.1
- DOI:
- 10.4238/2013.June.11.1
Genetic parameters for carcass traits and body weight using a Bayesian approach in the Canchim cattle
Authors: S.L.C. Meirelles, F.B. Mokry, A.C. EspasandÃ?Ân, M.A.D. Dias, M.M. Baena and L.C. de A. Regitano
Correlation between genetic parameters and factors such as backfat thickness (BFT), rib eye area (REA), and body weight (BW) were estimated for Canchim beef cattle raised in natural pastures of Brazil. Data from 1648 animals were analyzed using multi-trait (BFT, REA, and BW) animal models by the Bayesian approach. This model i.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027471
- DOI:
- 10.4238/gmr.15027471
Increased androgen receptor messenger RNA in frontal-parietal hair follicles of women with androgenetic alopecia
Authors: F. Richeti, C. Kochi, M.N. Rocha, C. Santâ��Anna Corr�ªa, R. Lazzarini, R.M. Guazzelli, R.F. Mendon�§a, M.R. Melo and C.A. Longui
Normal testosterone levels are frequently observed in women with androgenetic alopecia (AGA), suggesting the involvement of androgen sensitivity in this condition. Androgen sensitivity is related to androgen receptor (AR) messenger RNA (mRNA) production in hair follicles and is negatively related to the number of CAG repeats present in exon 1 of the AR ge.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.February.28.19
- DOI:
- 10.4238/2013.February.28.19
IL-16 rs4778889 polymorphism contribution to the development of renal cell cancer in a Chinese population
Authors: S.X. Yang, F. Chen, J.W. Zhang, Z.Q. Sun and B.P. Chen
IL-16 plays an important role in affect the secretion of tumor-related inflammatory cytokines. We aimed to assess the role of interleukin-16 (IL-16) rs4778889 T/C and rs11556218 T/G polymorphisms in the occurrence of renal cell cancer (RCC). This study is composed of 274 RCC patients and 274 control subjects. Genotyping of pol.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027553
- DOI:
- 10.4238/gmr.15027553
Association between the interleukin-1�² gene -511C/T polymorphism and ischemic stroke: an updated meta-analysis
Authors: W. Yan, Z.Y. Chen, J.Q. Chen and H.M. Chen
Numerous studies have investigated the relationship between the interleukin-1β gene (IL1B) -511C/T polymorphism and ischemic stroke (IS) risk. However, the results are inconsistent. We performed this meta-analysis of all available case-control studies that evaluated the relationship between the IL1B -511C/T polymorphism a.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027580
- DOI:
- 10.4238/gmr.15027580
Plasticity of Corynebacterium diphtheriae pathogenicity islands revealed by PCR
Authors: S.C. Soares, F.A. Dorella, L.G.C. Pacheco, R. Hirata Jr., A.L. Mattos-Guaraldi, V. Azevedo and A. Miyoshi
Despite the existence of a vaccine against diphtheria, this disease remains endemic and is reemerging in several regions due to many factors, including variations in genes coding for virulence factors. One common feature of virulence factors is their high concentration in pathogenicity islands (PAIs), very unstable regions acq.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1211
- DOI:
- 10.4238/vol10-2gmr1211
Construction of a primary DNA fingerprint database for cotton cultivars
Authors: Y.C. Zhang, M. Kuang, W.H. Yang, H.X. Xu, D.Y. Zhou, Y.Q. Wang, X.A. Feng, C. Su and F. Wang
Forty core primers were used to construct a DNA fingerprint database of 132 cotton species based on multiplex fluorescence detection technology. A high first successful ratio of 99.04% was demonstrated with tetraplex polymerase chain reaction. Forty primer pairs amplified a total of 262 genotypes among 132 species, with an average of 6.55 per primer and v.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.January.30.3
- DOI:
- 10.4238/2013.January.30.3
Dysregulation of TFDP1 and of the cell cycle pathway in high-grade glioblastoma multiforme: a bioinformatic analysis
Authors: X. Lu, X.D. Lv, Y.H. Ren, W.D. Yang, Z.B. Li, L. Zhang and X.F. Bai
Despite extensive research, the prognosis of high-grade glioblastoma multiforme (GBM) has improved only slightly because of the limited response to standard treatments. Recent advances (discoveries of molecular biomarkers) provide new opportunities for the treatment of GBM. The aim of the present study was to identify diagnost.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027646
- DOI:
- 10.4238/gmr.15027646
Th17/Treg cell expression in children with primary nephritic syndrome and the effects of ox-LDL on Th17/Treg cells
Authors: Y.Y. Li, S.G. Wei, X. Zhao, Y.Z. Jia, Y.F. Zhang and S.Z. Sun
To investigate the role of T-helper cells/Treg (Th17/Treg) and morbidity factors related to primary nephritic syndrome (PNS) in children, as well as the influence of ox-low density lipoprotein (ox-LDL) on Th17/Treg expression in children with PNS. To clarify the pathogenesis of PNS in children, 50 children with PNS treated in .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027669
- DOI:
- 10.4238/gmr.15027669