Association between N-acetyltransferase 2 polymorphisms and pancreatic cancer risk: a meta-analysis
Authors: J.X. Liang, W. Gao, Y. Liang and X.M. Zhou
N-acetyltransferase 2 (NAT2) is an essential phase II enzyme in the metabolism of aromatic and heterocyclic amines and of hydrazines. NAT2 activity can be divided into three phenotypes: rapid, intermediate, and slow. Studies identifying an association between NAT2 polymorphism and the risk of pancreatic cancer have shown conflicting results. In order to a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.21
- DOI:
- 10.4238/2015.December.16.21
Distribution of LIM domain kinase 1 in the olfactory bulb, cerebral cortex, hippocampus, and cerebellum of the App/PS+/- mice
Authors: L. An, J. Liu, W.W. Li, Y.J. Shi, X.H. Lin, D.M. Yu, J.B. Deng and X.Q. Ren
LIM domain kinase 1 (LIMK1), an actin-binding kinase, can phosphorylate and inactivate its substrates, and can regulate long-term memory and synaptic plasticity. Both β-amyloid precursor protein (App) and presenilin (PS) are functional degeneration factors during early neuronal development, and are considered as potential factors that contribute to t.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.24
- DOI:
- 10.4238/2015.December.16.24
Association of single nucleotide polymorphisms in the CYP1B1 gene with the risk of primary open-angle glaucoma: a meta-analysis
Authors: Z Wang, M. Li, L. Li, H. Sun and X.Y. Lin
Mutations in the CYP1B1 gene were detected in primary open-angle glaucoma (POAG) patients. However, the association between these mutations and the incidence of POAG remains to be elucidated. Here, we have conducted a meta-analysis to analyze this correlation, using relevant studies obtained from an extensive search of various electronic databases, includ.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.26
- DOI:
- 10.4238/2015.December.16.26
Phylogenetic study and barcoding of the blood cockle, Tegillarca granosa, found on the west coast of peninsular Malaysia using the COI gene
Authors: S.Y. Chee, M.N. Devakie, M.N. Siti Azizah
Blood cockles are among the most economically important brackish water invertebrates found in Malaysia. However, our knowledge of blood cockle phylogeny and systematics is rudimentary, especially for the species Tegillarca granosa. It is unclear, for instance, whether the cockles occurring on the west coast of peninsular Malay.. Read More»
- Genet. Mol. Res. 10(2):
Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population
Authors: J.J. Jin, H.Q. Wang, H.P. Kuang, B.B. Kang, Y.H. Liu and J. Wang
Lung cancer is the most common cancer occurring worldwide. The human X-ray repair complementing group 1 (XRCC1) gene is one of the most important candidate genes that influence the susceptibility to lung cancer. The objective of this study was to analyze the potential association between the c.1804C>A genetic variant of XRC.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15024661
- DOI:
- 10.4238/gmr.15024661
Expression of GRIN2A in benign and malignant nasopharyngeal diseases and its clinical significance
Authors: X.J. Zhou, B.R. Lin and Y. Wang
The gene glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A) is associated with development and neuron viability, and our previous studies showed it to be substantially methylated in nasopharyngeal carcinoma, indicating a link to this disease. The aim of this work was to investigate GRIN2A expression and its clinical significance in nasophary.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.29
- DOI:
- 10.4238/2015.December.16.29
Effects of nucleotide usage on the synonymous codon usage patterns of biofilm-associated genes in Haemophilus parasuis
Authors: L.Y. Wang, L.N. Ma and Y.S. Liu
To provide a new perspective on the evolutionary characteristics shaping the genetic diversity of Haemophilus parasuis biofilms, the relative synonymous codon usage values, codon usage bias values, effective number of codons (ENC) values, codon adaptation index (CAI) values, and the base components were calculated. Our objecti.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027226
- DOI:
- 10.4238/gmr.15027226
Meta-analysis of the TNF-�±-308G/A polymorphism and vitiligo risk
Authors: G. Nie, J.H. Qi, C.W. Huang, T. Yang, N. Shi and Y.J. Chen
Several case-control studies have been conducted to investigate the association between the tumor necrosis factor-α (TNF-α)-308G/A polymorphism and vitiligo risk. However, the results of these studies are inconsistent; therefore, we attempted to comprehensively evaluate the association between TNF-α-308G/A polymorphism and vitiligo risk .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.30
- DOI:
- 10.4238/2015.December.16.30
Major quality trait analysis and QTL detection in hexaploid wheat in humid rain-fed agriculture
Authors: H.M. Li, Z.X. Tang, H.Q. Zhang, B.J. Yan and Z.L. Ren
Humid rain-fed agriculture is a special environment for wheat (Triticum aestivum) culture that tends to negatively affect wheat yield and quality. To identify quality characters of wheat in a humid environment, we conducted quality analysis and quantitative trait loci (QTL) detection in a recombinant inbred line whose parent had a high level of quality fo.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.21.5
- DOI:
- 10.4238/2013.May.21.5
Identification of genes and pathways related to lipopolysaccharide signaling in duckling spleens
Authors: B. Deng, T. Yu, W. Liu, S.Q. Ye, L.X. Wang, Y. Yang, P. Gong, Z.P. Ran, H.J. Huang and J.H. Wen
Lipopolysaccharide (LPS), the major component of the outer cell wall of Gram-negative bacteria, activates the immune system and threatens the health of livestock and poultry. However, little is known about the genes and pathways involved in the immune response of ducklings to LPS. To elucidate the genes involved in the response of 7-day-old duckling splee.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.32
- DOI:
- 10.4238/2015.December.16.32