Genetic diversity of gabiroba based on random amplified polymorphic DNA markers and morphological characteristics
Authors: E.S. de Assis, E.F. dos Reis, J.F.N. Pinto, L.A.S. Contim and L.A.S. Dias
The fragmentation of the original vegetation of the Cerrado biome, caused by the expansion of agricultural areas, mainly in central-west Brazil, calls for an assessment of the native population of this vegetation, especially of the species of interest for domestication and sustainable use. The purpose of this study was to characterize the genetic diversit.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.7
- DOI:
- 10.4238/2013.March.11.7
Correlation between serum IL-16 and atopic dermatitis
Authors: H.Y. Zheng, L. Zhao, C.X. Li and S.H. Li
This study aims to investigate the correlation between allergic sensitization of atopic dermatitis (AD) patients and their serum interleukin (IL)-16 levels. AD patients, healthy volunteers, and patients with psoriasis (N = 80, 35, 20, respectively) were tested for serum IL-16 and total and specific IgE levels by enzyme-linked .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016556
- DOI:
- 10.4238/gmr.15016556
Roles of functional NFKB1 and �²-TrCP insertion/deletion polymorphisms in mRNA expression and epithelial ovarian cancer susceptibility
Authors: Z.H. Huo, H.J. Zhong, Y.S. Zhu, B. Xing and H. Tang
Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological cancers. Nuclear factor-kappa B (NF-κB) is involved in carcinogenesis and in the development of EOC. The β-transducin repeat-containing protein (β-TrCP) is a positive regulator of the NF-κB signaling pathway. Recent studies have indicated that the -.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.6
- DOI:
- 10.4238/2013.March.11.6
Polymorphisms in promoter regions of IL-6 and IL-10 genes in breast cancer: a case-control study
Authors: E.S. AlSuhaibani, N.A. Kizilbash, S. Malik, J.I. Dasti, F. Al Beladi and N. El-Morshedi
Polymorphisms in interleukin genes (IL-6 and IL-10) are involved in the pathogenesis of breast cancer. This study investigated polymorphisms in the promoter regions of IL-6 (-174G/C) and IL-10 (-1082G/A) through a case-control study employing 80 female subjects who were pathologically diagnosed with breast cancer. All patients received follow-up care at t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017360
- DOI:
- 10.4238/gmr.15017360
Association of APOA1 and APOA5 polymorphisms and haplotypes with lipid parameters in a Brazilian elderly cohort
Authors: T.K. Furuya, E.S. Chen, V.K. Ota, D.R. Mazzotti, L.R. Ramos, M.S. Cendoroglo, L.Q. Araujo, R.R. Burbano and M.A.C. Smith
Apolipoproteins have an important role in lipid metabolism and transport. Polymorphisms in the APOA1/C3/A4/A5 gene cluster have been associated with lipid alterations and cardiovascular diseases. We investigated APOA1 XmnI, APOA5 S19W, and APOA5 -1131T>C polymorphisms in 377 individuals from a cohort of a longitudinal Brazilian elderly study. Allele fr.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.7
- DOI:
- 10.4238/2013.February.28.7
Spermiotaxonomy of the tribe Rhodniini (Hemiptera, Triatominae)
Authors: A. Ravazi, J. Oliveira, J.A. Rosa, M.T.V. Azeredo-Oliveira and K.C.C. Alevi
The tribe Rhodniini is a monophyletic group composed of 22 species, with 19 in the Rhodnius genus and three in the Psammolestes genus. These insects are morphologically very similar (cryptic species), and new tools are important for investigating the taxonomy of these vectors. Spermiotaxonomy is an important tool in differentiating between related species.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017366
- DOI:
- 10.4238/gmr.15017366
Lack of an effect of CYP3A4 and MDR1 gene polymorphisms on colchicine pharmacogenetics in the treatment of Familial Mediterranean fever
Authors: D. Dogruer, E. Tug, C. Bes and M. Soy
The P-gp/MDR1 multidrug transporter mediates detoxification of numerous drugs, including colchicine, and CYP3A4 is key to the biotransformation of colchicine. We investigated the effects of CYP3A4 and P-gp/MDR1 polymorphisms on bioavailability of colchicine in patients with Familial Mediterranean fever (FMF). Forty-eight Turkish patients with FMF treated .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.24.2
- DOI:
- 10.4238/2013.January.24.2
Comparative and joint analyses of gene expression profiles under drought and rewatering in Arabidopsis
Authors: Z.H. Xu and W.R. Wu
Drought is a major limiting factor in crop production. Rewatering is a process opposite to drought, allowing plants to recover to their normal physiological state. To understand more thoroughly the set of genes involved in plant response to drought, we comparatively and jointly analyzed the microarray data of drought and rewatering experiments in Arabidop.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.6
- DOI:
- 10.4238/2013.September.13.6
Genetic determinants of the defense response of resistant and susceptible pepper (Capsicum annuum) cultivars infected with Phytophthora capsici (Oomycetes; Pythiaceae)
Authors: Y.-L. Zhang, D.-W. Li, Z.-H. Gong, J.-E. Wang, Y.-X. Yin and J.-J. Ji
Based on culture isolation and morphological observation blight-infected pepper plants in Shaanxi Province, China, we identified the pathogen causing pepper phytophthora blight as Phytophthora capsici. Varieties that differed in resistance (CM334, PBC602, and B27) were inoculated with this pathogen. The root activity of resistant CM334 variety was the hig.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.5
- DOI:
- 10.4238/2013.September.13.5
Molecular analysis of the SMN gene mutations in spinal muscular atrophy patients in China
Authors: W.L. Liu, F. Li, Z.X. He, R. Ai and H.W. Ma
Spinal muscular atrophy (SMA) is one of the most common autosomal recessive diseases. Survival motor neuron1 (SMN1) is the SMA disease-determining gene. We examined the molecular basis of SMA in 113 Chinese SMA patients. Homozygous exon 7 and 8 deletions in SMN1 were detected by PCR-RFLP. Heterozygous deletion of SMN1 was analyzed based on variation of th.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.4
- DOI:
- 10.4238/2013.September.13.4