Methylation regulation of liver-specific microRNA-122 expression and its effects on the proliferation and apoptosis of hepatocellular carcinoma cells
Authors: T.J. Xing, H.T. Xu, W.Q. Yu and D.F. Jiang
The regulation mechanism and significance of microRNA-122 (miRNA-122) expression are unclear. The aim of this study was to investigate the effects of DNA methylation on liver-specific miRNA-122 expression, cell proliferation, and apoptosis in hepatocellular carcinoma. Methylation of the miRNA-122 promoter region was detected through methylation sequencing.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.3
- DOI:
- 10.4238/2013.September.13.3
Mutagenicity, genotoxicity, and scavenging activities of extracts from the soft coral Chromonephthea braziliensis: a possibility of new bioactive compounds
Authors: R.M. Carpes, B.G. Fleury, B.G. Lages, A.C. Pinto, C.A.F. Aiub and I. Felzenszwalb
Coral reefs are diverse ecosystems that have a high density of biodiversity leading to intense competition among species. These species may produce unknown substances, many with pharmacological value. Chromonephthea braziliensis is an invasive soft coral from the Indo-Pacific Ocean that is possibly transported by oil platforms and whose presence can be a .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.2
- DOI:
- 10.4238/2013.September.13.2
Meiotic pairing of B chromosomes, multiple sexual system, and Robertsonian fusion in the red brocket deer Mazama americana (Mammalia, Cervidae)
Authors: C.I. Aquino, V.V. Abril and J.M.B. Duarte
Deer species of the genus Mazama show significant inter- and intraspecific chromosomal variation due to the occurrence of rearrangements and B chromosomes. Given that carriers of aneuploidies and structural rearrangements often show anomalous chromosome pairings, we here performed a synaptonemal complex analysis to study chromosome pairing behavior in a r.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.1
- DOI:
- 10.4238/2013.September.13.1
Characterization and molecular mapping of a dwarf mutant in wheat
Authors: X.J. Jin, D.F. Sun, H.Y. Li, Y. Yang and G.L. Sun
A spontaneous dwarf mutant of wheat was found in an F5 generation line derived from a cross between Huamai No. 9 and Een No. 1 in 1998; it was named Huaai 01. We characterized the genetic pattern of Huaai 01 and mapped the gene controlling the dwarf trait. This dwarf mutant was found insensitive to exogenous gibberellic acid treatment, based on the length.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.12.2
- DOI:
- 10.4238/2013.September.12.2
Mitochondrial and nuclear genes as the cause of complex I deficiency
Authors: A.R. Rezaee, A. Azadi, M. Houshmand, F. Mahmoodi, Z. Purpak, S. Safaei, P. Karimi, M. Ghabaee and M.A. Sahraian
Multiple sclerosis (MS) is an immunological inflammatory disease of the central nervous system. The pathogenesis of MS is incompletely understood, but various studies have suggested that mitochondrial dysfunction is associated with the disease. Mitochondria are among the main cellular sources of reactive oxygen and nitrogen species, and they play a pivota.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.12.1
- DOI:
- 10.4238/2013.September.12.1
Genetic diversity studies in pea (Pisum sativum L.) using simple sequence repeat markers
Authors: P. Kumari, N. Basal, A.K. Singh, V.P. Rai, C.P. Srivastava and P.K. Singh
The genetic diversity among 28 pea (Pisum sativum L.) genotypes was analyzed using 32 simple sequence repeat markers. A total of 44 polymorphic bands, with an average of 2.1 bands per primer, were obtained. The polymorphism information content ranged from 0.657 to 0.309 with an average of 0.493. The variation in genetic diversity among these cultivars ran.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.13.12
- DOI:
- 10.4238/2013.March.13.12
A molecular marker for in situ genetic resource conservation of Capsicum annuum var. acuminatum (Solanaceae)
Authors: N. Kaewdoungdee and T. Tanee
The Thailand cultivar pepper ‘phrik man bangchang’ (Capsicum annuum var. acuminatum, Solanaceae) was originally cultivated in the Bangchang Subdistrict, Amphawa District in Samut Songkhram Province. The cultivated areas are limited; we verified its distribution in Thailand for in situ ‘phrik man bangchang’ genetic resource conserva.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.10
- DOI:
- 10.4238/2013.February.28.10
Chromosomal characteristics of a Brazilian whip spider (Amblypygi) and evolutionary relationships with other arachnid orders
Authors: E. Paula-Neto, D. Araujo, L.S. Carvalho, D.M. Cella and M.C. Schneider
We analyzed mitotic and meiotic cells of a Brazilian amblypygid, Heterophrynus longicornis, using conventional and molecular cytogenetic techniques (Giemsa staining, C-banding, Ag-NOR, and FISH with rDNA probe). This is the first study that focuses solely on amblypygid chromosomes; it was undertaken to add data on cytogenetic knowledge of this group and c.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.3
- DOI:
- 10.4238/2013.September.19.3
Antigenotoxic and anticytotoxic activity of Duguetia furfuracea in bacteria and mice
Authors: C.R. Silva, P.M. Vieira and L. Chen-Chen
Duguetia furfuracea (St. Hil.) Benth & Hook f. (1862), popularly known as â????sofre-do-rim-quem-querâ??? and â????araticum-secoâ???, is a shrub of the Annonaceae family that grows in several regions of Brazil. Infusions of its leaves and twigs are used in folk medicine to treat rheumatism and renal colic, whe.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.2
- DOI:
- 10.4238/2013.September.19.2
Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis
Authors: G.J. Suo and Z.X. Zhao
We examined the association of the interleukin-28B (IL-28B) gene rs12979860 T/C polymorphism with development of hepatitis virus-related hepatocellular carcinoma (HCC) and liver cirrhosis (LC). Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library, and Chinese National Knowledge Infrastructure data bas.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.1
- DOI:
- 10.4238/2013.September.19.1