Potential role of Atp5g3 in epigenetic regulation of alcohol preference or obesity from a mouse genomic perspective
Authors: Y. Huang, L. Wang, B. Bennett, R.W. Williams, Y.J. Wang, W.K. Gu and Y. Jiao
The mitochondrial ATP synthase, subunit c, isoform 3 gene (Atp5g3) encodes subunit 9, the subunit of the multisubunit enzyme that catalyzes ATP synthesis during oxidative phosphorylation in mitochondria. According to the Ensembl database, Atp5g3 in mice is located on chromosome 2 between 73746504 and 73749383 bp, within the genomic regions of two sets of .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.18.1
- DOI:
- 10.4238/2013.September.18.1
Molecular cloning, polymorphisms, and association analysis of the promoter region of the STAM2 gene in Wuchuan Black cattle
Authors: Y.-Q. Yang, Y.-T. Hui, R.-Y. Liu, R.-G. Jiao, Y. Gong, Y.-Y. Zhang and H.-Q. Xie
The STAM protein plays an important role in the cytokine-related JAK/STAT pathway. We selected the STAM2 gene as a candidate gene that could be linked to growth performance in analysis of a Chinese cattle breed (Wuchuan Black cattle). We examined genetic variants in the promoter region of the STAM2 gene and their associations with eight growth traits in 1.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.9
- DOI:
- 10.4238/2013.September.13.9
Significant association of APOA5 and APOC3 gene polymorphisms with meat quality traits in Kele pigs
Authors: Y.T. Hui, Y.Q. Yang, R.Y. Liu, Y.Y. Zhang, C.J. Xiang, Z.Z. Liu, Y.H. Ding, Y.L. Zhang and B.R. Wang
Apolipoprotein A5 (APOA5) and C3 (APOC3) genes are involved in the PPAR lipid metabolism pathway and thus associated with elevated triglyceride levels. However, whether APOA5 and APOC3 genetic polymorphisms affect intramuscular fat deposition and other meat quality traits remains unknown in pigs. One hundred and seventy-one Kele pigs were sampled to inves.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.8
- DOI:
- 10.4238/2013.September.13.8
Physiological quality and gene expression related to heat-resistant proteins at different stages of development of maize seeds
Authors: T. Andrade, E.V.R. Von Pinho, R.G. Von Pinho, G.E. Oliveira, V. Andrade and J.S. Fernandes
We quantified and characterized the expression of heat-resistant proteins during seed development of maize lines with distinct levels of tolerance to high drying temperature. A corn field was planted for multiplication of seeds of different lines, two tolerant and two non-tolerant to high drying temperatures. Harvest of the seeds was carried out at variou.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.7
- DOI:
- 10.4238/2013.September.13.7
Genetic diversity of natural populations of Machilus thunbergii, an endangered tree species in eastern China, determined with ISSR analysis
Authors: J. Liu, H.G. Sun, J.M. Jiang, W.H. Shao and Q.F. Luan
The genetic diversity of 10 Machilus thunbergii populations in eastern China was analyzed using inter-simple sequence repeat markers. The populations showed high genetic diversity, with an overall population genetic diversity of 0.2343. Genetic diversity varied largely among populations, and populations with the highest genetic diversity were mainly from .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.10
- DOI:
- 10.4238/2013.March.11.10
Prevalence of variants that confer risk for venous thromboembolism in an elderly population of northeastern Brazil
Authors: H. Ferreira-Fernandes, P.N. Costa, H.F. Fernandes, A.P. Ara�ºjo-Neto, F.J. Motta, R. Canalle, F.K. Yoshioka, J.F. Guerreiro, R.R. Burbano, J.A. Rey and G.R. Pinto
Venous thromboembolism (VTE) is an important cause of morbidity and mortality stemming from cardiovascular disease. It is a multifactorial disease caused by a combination of acquired risk factors, of which advanced age is the most significant, and genetic factors, including the variants FV G1691A, FII G20210A, and MTHFR C677T. We estimated the prevalence .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.Mach.11.5
- DOI:
- 10.4238/2013.Mach.11.5
Breeding of transgenic cattle for human coagulation factor IX by a combination of lentiviral system and cloning
Authors: P.S. Monzani, J.R. Sangalli, T.H.C. De Bem, F.F. Bressan, P. Fantinato-Neto, J.R.V. Pimentel, E.H. Birgel-Junior, A.M. Fontes, D.T. Covas and F.V. Meirelles
Recombinant coagulation factor IX must be produced in mammalian cells because FIX synthesis involves translational modifications. Human cell culture-based expression of human coagulation factor IX (hFIX) is expensive, and large-scale production capacity is limited. Transgenic animals may greatly increase the yield of therapeutic proteins and reduce costs... Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.25
- DOI:
- 10.4238/2013.February.28.25
Genetic polymorphisms of the TLR4 gene and their association with susceptibility to type 2 diabetes mellitus in the Chinese population
Authors: X.D. Fu, X.Q. Sun, H.Y. Wang, J.F. Guo, G.Z. Zhang and Q.H. Xu
Toll-like receptor 4 (TLR4) is potentially an important gene affecting the susceptibility to type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate whether genetic polymorphisms of the TLR4 gene are associated with T2DM susceptibility. This potential association was analyzed in 668 T2DM patients and 672 healthy controls by polymerase.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.13
- DOI:
- 10.4238/2013.September.19.13
Relationship between multidrug resistance 1 polymorphisms and the risk of prostate cancer in Chinese populations
Authors: F.R. Shen , C.Y. Yan, M. Liu, Y.H. Feng and Y.G. Chen
Prostate cancer is one of the most common malignancies in men. The multidrug resistance 1 gene (MDR1) is an important candidate gene for prostate cancer. The aim of this study was to evaluate the association between MDR1 gene polymorphisms and the risk of prostate cancer. MDR1 gene polymorphism and its association with the risk of prostate cancer were inv.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.12
- DOI:
- 10.4238/2013.September.19.12
Identification of miRNAs and their targets in wheat (Triticum aestivum L.) by EST analysis
Authors: J. Han, M.L. Kong, H. Xie, Q.P. Sun, Z.J. Nan, Q.Z. Zhang and J.B. Pan
MicroRNAs (miRNAs) are a newly discovered class of noncoding small RNAs that regulate gene expression by directing target mRNA cleavage or translational inhibition. A large number of miRNAs have been identified in plants. Increasing evidence has shown that miRNAs play multiple roles in plant biological processes. So far, identification of miRNAs has been .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.11
- DOI:
- 10.4238/2013.September.19.11