Anatomical alterations due to polyploidy in cassava, Manihot esculenta Crantz
Authors: Nagib M.A. Nassar, D. Graciano-Ribeiro, S.D.C. Fernandes and P.C. Araujo
Information on anatomical structure is needed by breeders working on improvement for drought tolerance. For studying the effect of polyploidy on cassava anatomy and its significance to tolerance to drought, we induced a polyploidy type of a selected clone (UnB 530) by applying an aqueous solution of 0.2% colchicine on lateral .. Read More»
- Genet. Mol. Res. 7(2):
- vol7-2gmr399
- DOI:
- 10.4238/vol7-2gmr399
Effect of UBE3C polymorphisms on intramuscular fat content and fatty acid composition in Duroc pigs
Authors: P. Supakankul and S. Mekchay
Ubiquitin protein ligase E3C (UBE3C) is involved in the ubiquitin-proteasome pathway, and several ubiquitin protein ligases are important for fat deposition and lipid metabolism. The objective of this study was to analyze the association between a single nucleotide polymorphism (SNP) of the UBE3C gene with intramuscular fat (I.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038415
- DOI:
- 10.4238/gmr.15038415
High levels of glucose promote the activation of hepatic stellate cells via the p38-mitogen-activated protein kinase signal pathway
Authors: L.K. Wu, Y.C. Liu, G. Ma, L.L. Shi and X.M. He
The relationship between the p38-mitogen-activated protein kinase (p38-MAPK) signal pathway and high glucose-induced hepatic stellate cell (HSC) activation was investigated in this study. Sixty human HSC samples were randomly selected and used in the control (cultured normally), high-glucose (cultured in the presence of high g.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038419
- DOI:
- 10.4238/gmr.15038419
Administration of low-dose cyclosporine alone for the treatment of elderly patients with membranous nephropathy
Authors: M.X. Li, Y.W. Yu, Z.Y. Zhang, H.D. Zhao and F.L. Xiao
This study aimed to investigate the effects of administration of low-dose cyclosporine A (CsA) alone and the combination of low-dose CsA and a low-dose hormone for the treatment of elderly patients with membranous nephropathy. We divided 27 patients into two groups as follows: low-dose CsA group (group A) and the group receiving a combination of a low-dos.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.27
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.27
Birth of a healthy child by a woman with inherited Xq duplications who had experienced stillbirths
Authors: Y. Dong, S.C. Chen, X.W. Yu, E. Fadlalla, F. Jin and R.Z. Liu
23-year-old woman who had experienced repeated stillbirths, was found to carry an additional segment on the long arm of the X chromosome. Array comparative genomic hybridization (aCGH) confirmed the origin of the 2 duplications (about 17.11 Mb). Thus, her karyotype was 46, X, dup (X) (q13.2-q21.1), dup(X) (q21.32-q22.1). We de.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.17.9
- DOI:
- http://dx.doi.org/10.4238/2014.June.17.9
Correlative study between the JAK2V617F mutation and thrombosis in patients with myeloproliferative neoplasm
Authors: Z.C. Li, H.J. Fu, Z.M. Wang, S. Yang2and H.Z. Xu
In this study, we investigated the correlation between the JAK2V617F mutation and thrombosis in patients with myeloproliferative neoplasm (MPN) using real-time fluorescence quantitative PCR. The incidence of thrombus was monitored and blood and coagulation were routinely assayed in patients with MPN. The JAK2V617F mutation was.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038423
- DOI:
- 10.4238/gmr.15038423
Expression of genes related to tolerance to low temperature for maize seed germination
Authors: I.C. Silva-Neta, E.V. Pinho, A.D. Veiga, R.G. P�¬nho, R.M. Guimar�£es, F. Caixeta, H.O. Santos and T.L. Marques
The aim of this study was to characterize maize lines tolerant to cold temperatures during the germination process. Seeds from lines with different levels of tolerance to low temperatures were used; 3 lines were classified as tolerant and 3 as susceptible to low germination temperatures. A field was set up to multiply seeds from selected lines. After the .. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.28
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.28
Kallikrein 12 downregulation reduces AGS gastric cancer cell proliferation and migration
Authors: X.S. Li and X.L. He
Abnormal expression of the kallikrein (KLK) family of serine proteases closely correlates with onset, progression, and prognosis of endocrine gland-related malignant tumors. The aim of this study was to evaluate how downregulation of KLK12 influenced cell cycle and proliferation of the AGS gastric cancer cell line. KLK12 was d.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038452
- DOI:
- 10.4238/gmr.15038452
Activation of the ERK1/2 pathway by the CaMEK gene via adeno-associated virus serotype 9 in cardiomyocytes
Authors: Y.-N. Yang, W.-N. Ji1, Y.-T. Ma, X.-M. Li, B.-D. Chen, Y. Xiang and F. Liu
Extracellular signal-regulated kinase (ERK1/2) is one of the mitogen-activated protein kinases, key components of the reperfusion injury salvage kinase pathway, which plays an important role in protecting the myocardium from lethal ischemia-reperfusion injury. Constitutive activation of the mitogen-activated protein kinase kinase 1 (CaMEK) can promote ERK.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.17.1
- DOI:
- 10.4238/2012.October.17.1
Unusual chromosome numbers in Paspalum L. (Poaceae: Paniceae) from Brazil
Authors: A.P.S. Pe�±aloza, A.L. C�´rtes, M.T. Pozzobon, S. Santos,G.H. Rua and J.F.M. Valls
Somatic chromosome numbers were determined for 20 new germplasm accessions of Paspalum, belonging to 17 species collected in Brazil. Chromosome number is reported for the first time for P. reduncum (2n = 18), P. cinerascens (2n = 20), P. cordatum (2n = 20), P. filgueirasii (2n = 24), P. ammodes (2n = 36), P. bicilium (2n = 40).. Read More»
- Genet. Mol. Res. 7(2):
- vol7-2gmr431
- DOI:
- 10.4238/vol7-2gmr431