ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy
Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2
We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.16
- DOI:
- 10.4238/2014.December.4.16
ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy
Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2
We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.16
- DOI:
- 10.4238/2014.December.4.16
Association between the -77T>C polymorphism in the DNA repair gene XRCC1 and lung cancer risk
Authors: B.B. Sun, J.Z. Wu, Y.G. Li and L.J. Ma
Numerous studies have evaluated the association between the X-ray repair cross-complementing group 1 (XRCC1) DNA repair gene polymorphism -77T>C and lung cancer risk. However, this association is controversial. We used PubMed and Embase to identify 5 case-control studies, which included 2488 lung cancer cases and 2576 controls, for inclusion in a compr.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.17
- DOI:
- 10.4238/2014.December.4.17
Correlation of forkhead box transcription factor O1 and myosin heavy chain isoforms in porcine skeletal muscle
Authors: X.E. Shi, Z.Y. Song, Q.M. Yang, Y.G. Liu and G.S. Yang
We examined the expression of myosin heavy chain (MyHC) isoforms and forkhead box transcription factor O1 (FoxO1) in porcine soleus and extensor digitorum longus (EDL) muscles to clarify the correlation of FoxO1 and the relative abundance of transcripts of MyHC isoforms. Soleus muscle was found to be redder than EDL muscles in pigs, and immunohistochemica.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.18
- DOI:
- 10.4238/2014.December.4.18
Molecular characterization of thioredoxin-1 and thioredoxin reductase activity in mud crab Scylla paramamosain
Authors: J.H. Hu1,2*, F.Y. Zhang1*, K.J. Jiang1, Y.B. Fang1,2, J. Wang1,2, M. Zhao1,2, Z.G. Qiao1 and L.B. Ma1
The thioredoxin (Trx) system consists of thioredoxin reductase (TrxR), Trx, and nicotinamide adenine dinucleotide phosphate (NADPH). TrxR is an NADPH-dependent oxidoreductase. Trx is a ubiquitous small protein with a redox-active disulfide bridge that plays important regulatory roles in some vital metabolic reactions. In this study, a cDNA sequence (SpTrx.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.19
- DOI:
- 10.4238/2014.December.4.19
Association between single-nucleotide polymorphisms and milk production traits in buffalo
Authors: G.C. Venturini1, D.F. Cardoso1, F. Baldi1, A.C. Freitas1, R.R. Aspilcueta-Borquis1, D.J.A. Santos1, G.M.F. Camargo1, N.B. Stafuzza2, L.G. Albuquerque1 and H. Tonhati1
The aim of this study was to identify single-nucleotide polymorphisms (SNPs) in buffaloes associated with milk yield and content, in addition to somatic cell scores based on the cross-species transferability of SNPs from cattle to buffalo. A total of 15,745 SNPs were analyzed, of which 1562 showed 1% significance and 4742 with 5% significance, which were .. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.20
- DOI:
- 10.4238/2014.December.4.20
MTA1 promotes cell proliferation via DNA damage repair in epithelial ovarian cancer
Authors: Q.Y. Yang1, J.H. Li2, Q.Y. Wang3, Y. Wu3, J.L. Qin3, J.J. Cheng3 and J. Qiu3
We examined whether metastasis-associated gene 1 (MTA1) promotes cell proliferation via DNA damage repair in ovarian cancer. MTA1 was successfully down-regulated using small interfering RNA in the epithelial ovarian cancer cell lines SKOV-3 and OVCAR-3. Cell growth was evaluated through MTT and colony formation assays. Fluorescence-activated cell sorting .. Read More»
- Genet. Mol. Res. 13(4):
Distribution of constitutive heterochromatin in species of triatomines with fragmentation of sex chromosomes X
Authors: A.L. Guerra1, K.C.C. Alevi1, J.A. Rosa2 and M.T.V. Azeredo-Oliveira1
Cytogenetic analyses of triatomines are considered to be important taxonomic tools. Thus, we analyzed the pattern of constitutive heterochromatin in 7 species of triatomine with fragmentation of the sex chromosome X, focusing on the cytotaxonomy of these triatomines. The species analyzed included Triatoma vitticeps, Triatoma melanocephala, Triatoma tibiam.. Read More»
- Genet. Mol. Res. 13(4):
Correlation between DQB1 genetic polymorphism and genetic susceptibility in patients diagnosed with irritable bowel syndrome with diarrhea
Authors: F. Yu1, S. Huang2, F. Zhou2, Q. Luo2, X. Xie3 and C. Zheng2
We examined patients of Han nationality diagnosed with irritable bowel syndrome with diarrhea (IBS-D) in Guangdong, China, to analyze the correlation between DQB1 allele polymorphisms and the genetic susceptibility to IBS-D. A total of 120 IBS-D patients of Han nationality in Guangdong, China, and 60 healthy control volunteers were included. DQB1 allele p.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.23
- DOI:
- 10.4238/2014.December.4.23
Genetic and phenotypic parameters of carcass and organ traits of broiler chickens
Authors: G.C. Venturini1, V.A.R. Cruz1, J.O. Rosa1, F. Baldi1, L. El Faro3, M.C. Ledur2, J.O. Peixoto2 and D.P. Munari1
The objective of this study was to estimate the genetic and environmental parameters for carcass, carcass part, and organ weights in a paternal strain of broiler chickens that was selected mainly for body weight at 42 days of age (BW42) to provide support for poultry genetic improvement programs. A total of 1448 chickens were used that resulted from the e.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.24
- DOI:
- 10.4238/2014.December.4.24