Promotion of apoptosis in high glucose-activated hepatic stellate cells by GLP-1 receptor agonist and its potential mechanism
Authors: Lingkang Wu, Yingchao Liu, Liangliang Shi, Bingbing Zhang, Ana Carolina Picolo Pasian and Andrei Moroz
This study aimed to investigate the stimulatory effect of glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1RA) on the apoptosis of hepatic stellate cells (HSCs) activated by high glucose, and to explore the underlying molecular mechanism with a focus on the c-Jun N-terminal kinase (JNK) and extracellular signal-related k.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039818
- DOI:
- 10.4238/gmr16039818
Genetics Analysis of the Biggest Cashew Tree in the World
Authors: F.P.M. do Amaral, G.H. de S�¡, L.A. Filgueiras, F.S. Santos Filho, C.J.R. Santos Soares, M.P.M. do Amaral, S.E. dos Santos Valente, A. N. Mendes
This study performed a genetic study of several canopies of Anacardium occidentale L. specimen called "Cashew King" (Cajueiro da Praia-PI, Brazil) in order to assess whether all canopies belong to the same plant. Leaves were collected from different distant points, and preserved for analysis of DNA. The analysi.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039817
- DOI:
- 10.4238/gmr16039817
DNA methylation profile of the DKK2 gene as a biomarker in patients with colorectal cancer
Authors: T.D. Silva, A.V. Felipe, V.M. Vidigal, S.S. Saad, N.M. Forones
Purpose: Epigenetic changes can be detected in precancerous lesions, suggesting that may be involved in the early stages of carcinogenesis. The methylation of specifics genes has been correlated with the outcome of many different types of cancers. This study compared the levels of DNA methylation between normal and tumor tissu.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039816
- DOI:
- 10.4238/gmr16039816
Comparative Study of Blood-Derived Scaffolds for the Culture of Human Adipose Derived Stem Cells (ASCS) and Dermal Fibroblasts
Authors: Helga Caputo Nunes, Rosana Rossi Ferreira,Ana Carolina Picolo Pasian, Andrei Moroz, Bruno Martinucci, Michele Janegitz Acorci Valerio,S�©rgio Alexandre Alc�¢ntara dos Santos, Henrique de Souza Vieira,S�©rgio Luis Felisbino, Elenice Deffune, Fl�¡via Karina Delella
This study aimed to compare the performance of bloodderived scaffolds with a well-known and accepted scaffold, chitosan, in maintaining cell cultures of ASCs and fibroblasts for future wound healing applications. Cells were characterized, immunophenotyped and cultivated into the following scaffolds: 1) Chitosan (CH, control), .. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039807
- DOI:
- 10.4238/gmr16039807
Characterization of the complete Chloroplast genome of Correa carmen, a valuable winter-flowering shrub
Authors: Minghui Chen, Yuxia Zong, Shiping Cheng, Zhilu Zhang
Correa carmen is considered important because of its considerable ornamental and economic value. The most striking characteristic of C. carmen flowers is their long winter-flowering period. In the present study, we generated the first complete C. carmen chloroplast genome sequence based on Illumina paired-end sequencing data. .. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039815
- DOI:
- 10.4238/gmr16039815
Physiological Traits and Their Relationships in Black Oat Populations
Authors: D. Meira, C. Meier, T. Olivoto, M. Nardino, A. Rigatti, A. Lunkes, R. Bordin, V.S. Marchioro and V.Q. Souza
The objective of this work was to verify physiological quality of black oat populations, in order to know and point out the relationships among physiological characters for selection of progenies. The experiment was carried out at the Laboratory of Plant Breeding and Production, Federal University of Santa Maria, Campus of Fre.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039814
- DOI:
- 10.4238/gmr16039814
Genetic Variability for Sprout Growth among Genotypes of Coffea canephora Led by Bending of Orthotropic Stems
Authors: W.N. Rodrigues, T.V. Colodetti, S.V.B. Brinate, L.D. Martins and M. A. Tomaz
The multi-stem aspect of crop systems using Coffea canephora makes it necessary to correctly establish the number of orthotropic stems per plant during the crop formation. The present study was developed to study the variability of responses among improved genotypes of C. canephora to the technique of bending orthotropic stems.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039813
- DOI:
- 10.4238/gmr16039813
Genome-Wide Analysis of a Radiation-Induced Lesion Mimic Mutant in Rice
Authors: Zhuo Zhenga, Mingcheng Guoa,b, Lihua Wua, Huimin Suna
Lesion mimic mutations (LMMs) are very useful genetic tools in plants, however, it is difficult to uncover genome-wide mutations using traditional technology, the development of whole genome sequencing (WGS) provides a means by which to identify genome-wide LMMs. In this study, WGS was performed to reveal the molecular mechani.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039812
- DOI:
- 10.4238/gmr16039812
Factor V Leiden G1691A and Prothrombin G20210A mutations are associated with repeated spontaneous miscarriage in Northern area of Saudi Arabia
Authors: Fakhr-Eldeen, A. Badawy, B. Abu AlSel and M. S. Fawzy
Maternally inherited thrombophilia could be one of the causes of recurrent spontaneous miscarriage (RSM). We aimed to investigate the frequency of three thrombotic gene variants; factor V Leiden (FVL; G1691A), prothrombin (PTH; G20210A), and methylenetetrahydrofolate reductase (MTHFR; C677T) in Saudi patients diagnosed with RS.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039810
- DOI:
- 10.4238/gmr16039810
AluYb8 insertion in the WNK1 gene is not associated with hypertension in a Russian Caucasian population
Authors: Elmira Akhmedova, Svetlana Y. Nikulina, Alla B. Salmina, Anna Chernova, Marina Bazanova, Anna Ohapkina, Aleksey Semenchukov, Paolo E. Maltese, Elena Manara and Matteo Bertelli
WNK1 (With No-lysine Kinase 1), a serine-threonine kinase, regulates blood pressure by acting on various sodium transport-related ion channels. Several studies report a link between common variants of the WNK1 gene and hypertension. No data exists on Russian populations. Our aim was to evaluate the association between the WNK1.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039809
- DOI:
- 10.4238/gmr16039809