Silencing miR-181a produces neuroprotection against hippocampus neuron cell apoptosis post-status epilepticus in a rat model and in children with temporal lobe epilepsy
Authors: L. Ren1*, R. Zhu2* and X. Li1
Epilepsy is one of the most frequent neurological disorders. Recently, the regulation of microRNAs was found to be associated with epilepsy, but the molecular mechanism by which microRNA influences epilepsy process remains to be unveiled and the development of microRNA-based therapy requires more intensive research. In this study, five microRNAs with pote.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017798
- DOI:
- 10.4238/gmr.15017798
Proteomic analysis identifies differentially expressed proteins participating in forming Type III brush hair in Yangtze River Delta white goat
Authors: B. Yang, M.Y. Cai, Y.J. Li, H. Zhang, G.H. Cheng, J.H. Zhang, G.J. Zhang, W.T. Li and D.J. Ji
The Yangtze River Delta white goat is a goat breed that can produce high quality brush hair (Type III hair) around the world. This study aimed to compare Type III hair and non-Type III hair goat skin tissues using differentially expressed proteins based on 2-dimensional gel electrophoresis technology. The differentially expressed protein spots were analyz.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.6
- DOI:
- 10.4238/2015.January.23.6
SNPs at 3'-UTR of the bovine CDIPT gene associated with Qinchuan cattle meat quality traits
Authors: C.Z. Fu H. Wang C.G. Mei J.L. Wang B.J. Jiang X.H Ma H.B. Wang G. Cheng L.S. Zan
As the most ancient member of the wheat gluten family, the ?³-gliadin genes are suitable for phylogenetic analysis among wheat and related species. Species in the grass genus Dasypyrum have been widely used for wheat cross breeding. However, the genomic relationships among Dasypyrum species have been little studied. We isolated 22 novel ?³-gliadin gene s.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.March.13.6
- DOI:
- 10.4238/2013.March.13.6
Evaluation of pH effects on genomic integrity in adipose-derived mesenchymal stem cells using the comet assay
Authors: L.C. Hermeto, R.J. Oliveira, R. Matuo, P.H.A. Jardim, R. DeRossi, A.C.M.B. Antoniolli, E. Deffune, T.C. Evaristo and ?.E. Santana
The use of mesenchymal stem cells (MSCs) in experimental, clinical, and therapeutic trials has grown in recent years. However, the issue remains of whether these procedures are completely safe for transplant patients. Therefore, this study was designed and carried out with the aim of evaluating two different comet assay protocols for genomic damage patter.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.7
- DOI:
- 10.4238/2015.January.23.7
Intraflagellar transport complex in Leishmania spp. In silico genome-wide screening and annotation of gene function
Authors: Gouveia JJS, Vasconcelos EJR, Pacheco ACL, Ara?ºjo-Filho R, Maia ARS, Kamimura MT, Costa MP, Viana DA, Costa RB , Maggioni R and Oliveira DM
Flagella are constructed and maintained through the highly conserved process of intraflagellar transport (IFT), which is a rapid movement of particles along the axonemal microtubules of cilia/ flagella. Particles that are transported by IFT are composed of several protein subunits comprising two complexes (A and B), which are .. Read More»
- Genet. Mol. Res. 6(4):
Chloroplast analysis of Zelkova schneideriana (Ulmaceae): genetic diversity, population structure, and conservation implications
Authors: H.L. Liu1,2, R.Q. Zhang2, M.L. Geng3, J.Y. Zhu1, J.C. An1 and J.L. Ma1
elkova schneideriana is endemic to China and belongs to the Ulmaceae. It is listed as a Near Threatened species in the China Biodiversity Red Data Book. We conducted a phylogeographical study of two chloroplast regions (psbA-trnH and trnG-trnM) in several Chinese Z. schneideriana populations, in order to examine the genetic diversity, population structure.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017739
- DOI:
- 10.4238/gmr.15017739
Isolation and phylogenetic analysis of novel ?³-gliadin genes in genus Dasypyrum
Authors: G.R. Li C. Liu E.N. Yang Z.J. Yang
As the most ancient member of the wheat gluten family, the ?³-gliadin genes are suitable for phylogenetic analysis among wheat and related species. Species in the grass genus Dasypyrum have been widely used for wheat cross breeding. However, the genomic relationships among Dasypyrum species have been little studied. We isolated 22 novel ?³-gliadin gene s.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.March.13.7
- DOI:
- 10.4238/2013.March.13.7
Cloning and characterization of a farnesyl pyrophosphate synthase from Matricaria recutita L. and its upregulation by methyl jasmonate
Authors: S.S. Su, H.M. Zhang, X.Y. Liu, G.F. Pan, S.P. Ling, X.S. Zhang,X.M. Yang, Y.L. Tai and Y. Yuan
Matricaria recutita (L.), commonly known as chamomile, is one of the most valuable medicinal plants because it synthesizes a large number of pharmacologically active secondary metabolites known as ?±-bisabolol and chamazulene. Although the plant has been well characterized in terms of chemical constituents of essential oil as well as pharmacological proper.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.8
- DOI:
- 10.4238/2015.January.23.8
Genetic diversity among red swamp crayfish (Procambarus clarkii) populations in the middle and lower reaches of the Yangtze River based on AFLP markers
Authors: B.F. Zhu Y. Huang Y.G. Dai C.W. Bi C.Y. Hu
The red swamp crayfish has become one of the most important freshwater aquaculture species in China. At present, although it is widely distributed in the middle and lower reaches of the Yangze River basin, little is known about its population genetics and geographic distribution in China. We estimated the genetic diversity among 6 crayfish populations from 4.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.March.13.8
- DOI:
- 10.4238/2013.March.13.8
Effect of ZNF217 gene polymorphisms on colorectal cancer development in a Mexican population
Authors: R. Ram?rez-Ram?rez, M. Guti?©rrez-Angulo, M.T. Maga?±a, J.M. Moreno-Ortiz, M. Partida-P?©rez, R. Mu?±iz-Mendoza, J. Peregrina-Sandoval, A.S. Su?¡rez-Villanueva, M. Centeno-Flores, V.M. Maciel-Guti?©rrez, E. Cabrales-Vazquez and M.L. Ayala-Madrigal
The ZNF217 gene, a potential oncogene amplified and overexpressed in several cancers including colorectal cancer (CRC), acts as a transcription factor that activates or represses target genes. The polymorphisms rs16998248 (T>A) and rs35720349 (C>T) in coronary artery disease have been associated with reduced expression of ZNF217. In this study, we analyzed t.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.9
- DOI:
- 10.4238/2015.January.23.9