Analysis of the mitochondrial COI gene and its informative potential for evolutionary inferences in the families Coreidae and Pentatomidae (Heteroptera)
Authors: H.V. Souza1, S.R.C. Marchesin2 and M.M. Itoyama1
The mitochondrial cytochrome oxidase subunit 1 (COI) gene is one of the most popular markers used for molecular systematics. Fragments of this gene are often used to infer phylogenies, particularly the region near the 5'-end, which is used by the DNA Barcoding Consortium. With a growing number of sequences being deposited in the DNA barcoding database, th.. Read More»
- Genet. Mol. Res. 15(1):
- 0.4238/gmr.15017428
- DOI:
- 0.4238/gmr.15017428
Genotype and phenotype correlations in diabetic patients in Uruguay
Authors: A. Mimbacas, L. GarcÃ?Âa, P. Zorrilla, M. Acosta, C. Airaudo, R. Ferrero, A. Pena, B. Simonelli, E. Soto, G. Vitarella, J. Fernandez and G. Javiel
To differentiate among different types of diabetes is becoming an increasingly challenging task. We investigated whether the patient’s genetic profile is useful to identify the particular type of diabetes, to determine the corresponding hyperglycemia pathogenesis and treat accordingly. Three hundred and thirty-eight diab.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr667
- DOI:
- 10.4238/vol8-4gmr667
A discriminative method for protein remote homology detection based on N-Gram
Authors: S. Xie, P. Li, Y. Jiang and Y. Zhao
Protein remote homology detection refers to detecting structural homology in proteins with an extremely low rate of sequence similarity. Such detection is primarily conducted using 3 methods: pairwise sequence comparisons, generative models for protein families, and discriminative classifiers. In this study, a discriminative classification method involvin.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.9
- DOI:
- 10.4238/2015.January.15.9
Lack of association of IL-2RA and IL-2RB polymorphisms with rheumatoid arthritis in a Han Chinese population
Authors: J. Zhu F. He D.D. Zhang J.Y. Yang J. Cheng R. Wu B. Gong X.Q. Liu S. Ma B. Zhou
Polymorphisms in IL-2RA and IL-2RB genes have been reported to confer susceptibility to rheumatoid arthritis (RA) in European populations. We investigated a possilbe association between SNPs in IL-2RA and IL-2RB genes and RA in a Han Chinese population. rs2104286 in IL-2RA and rs743777 in IL-2RB genes were genotyped in a Han Chinese cohort composed of 500 pa.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.27.7
- DOI:
- 10.4238/2013.February.27.7
Anticancer activity of Bombyx batryticatus ethanol extract against the human tumor cell line HeLa
Authors: W.P. Wu, J. Cao, J.Y. Wu, H. Chen and D. Wang
Anticancer activity of Bombyx batryticatus ethanol extract (BBE) against HeLa cells was studied using cell viability, DNA fragmentation, real-time polymerase chain reaction, and Western blot analyses. The BBE inhibited the growth and induced apoptosis of HeLa cells. The MTT assay indicated that the BBE induced cytotoxicity in HeLa cells in a time- and con.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.10
- DOI:
- 10.4238/2015.January.15.10
Genetic study of abdominal fat deposition and performance, and carcass and body composition traits in a male broiler line
Authors: L.G. Gaya
-.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4ta027
- DOI:
- 10.4238/vol8-4ta027
PDK2 and ABCG2 genes polymorphisms are correlated with blood glucose levels and uric acid in Tibetan gout patients
Authors: Y.C. Ren1,2*, T.B. Jin1,2,4,5*, X.D. Sun6, T.T. Geng2,3*, M.X. Zhang1,2, L. Wang4,5,T. Feng2, L.L. Kang4,5 and C. Chen1,2
Previous studies have shown that the PDK2 and ABCG2 genes play important roles in many aspects of gout development in European populations. However, a detailed genotype-phenotype analysis was not performed. The aim of the present study was to investigate the potential association between variants in these two genes and metabolism-related quantitative phen.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017447
- DOI:
- 10.4238/gmr.15017447
Synonymous codon usage patterns in different parasitic platyhelminth mitochondrial genomes
Authors: L. Chen D.Y. Yang T.F. Liu X. Nong X. Huang Y. Xie Y. Fu W.P. Zheng R.H. Zhang X.H. Wu X.B. Gu S.X. Wang X.R. Peng G.Y. Yang
We analyzed synonymous codon usage patterns of the mitochondrial genomes of 43 parasitic platyhelminth species. The relative synonymous codon usage, the effective number of codons (NC) and the frequency of G+C at the third synonymously variable coding position were calculated. Correspondence analysis was used to determine the major variation trends shapin.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.27.8
- DOI:
- 10.4238/2013.February.27.8
Correlation-based linear discriminant classification for gene expression data
Authors: M. Pan and J. Zhang
Microarray gene expression technology provides a systematic approach to patient classification. However, microarray data pose a great computational challenge owing to their large dimensionality, small sample sizes, and potential correlations among genes. A recent study has shown that gene-gene correlations have a positive effe.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019357
- DOI:
- 10.4238/gmr16019357
Isolation and characterization of novel microsatellite markers for molecular genetic diversity in Siganus fuscescens
Authors: Y.F. Ning, Z.B. Li, Q.H. Li, G. Dai, J.B. Shangguan, Y. Yuan and Y.S. Huang
The rabbitfish Siganus fuscescens is an economically valuable species that is widely distributed throughout the estuaries, intertidal, and offshore coasts of the Indo-Pacific and eastern Mediterranean. Ten novel microsatellite loci from the genome of S. fuscescens were developed using the fast isolation protocol with amplified fragment length polymorphism.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.11
- DOI:
- 10.4238/2015.January.15.11